KCNH2 and KCNE2

Number of citations of the paper that reports this interaction (PMID 11278781)
16

Data Source:
HPRD (in vivo)

		KCNH2	KCNE2
Gene Name		potassium channel, voltage gated eag related subfamily H, member 2	potassium channel, voltage gated subfamily E regulatory beta subunit 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface
	Molecular Function	Phosphorelay Sensor Kinase Activity Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Regulator Activity Protein Homodimerization Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Phosphorelay Signal Transduction System Regulation Of Heart Rate By Hormone Synaptic Transmission Signal Transduction By Phosphorylation Cellular Response To Drug Regulation Of Membrane Potential Potassium Ion Homeostasis Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export	Aging Potassium Ion Import Cellular Protein Localization Cellular Response To Drug Tongue Development Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Inward Rectifier Potassium Channel Activity Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Potassium Channels Voltage gated Potassium channels
Drugs		Dofetilide Amsacrine Ibutilide Terfenadine Prazosin Sotalol Doxazosin Cisapride Astemizole Verapamil Thioridazine Quinidine Pimozide Miconazole Amiodarone Carvedilol Terazosin Propafenone Halofantrine Dronedarone Sertindole
Diseases
GWAS		Electrocardiographic traits ( 20062061 20062063) QT interval ( 23166209 19305408 19305409)	Body mass index (interaction) ( 23192594) Height ( 20881960) Myocardial infarction (early onset) ( 19198609) Pulmonary function ( 21946350)
Protein-Protein Interactions		10 interactors: ALG10 ALG10B CDC73 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH	2 interactors: KCNH2 KCNQ1
Entrez ID		3757	9992
HPRD ID		01069	04813
Ensembl ID		ENSG00000055118
Uniprot IDs		Q12809 Q15BH2	Q9Y6J6
PDB IDs		1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 4HP9 4HQA
Enriched GO Terms of Interacting Partners?		Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cardiac Conduction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization Regulation Of Heart Rate Action Potential Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Regulation Of Heart Contraction Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Striated Muscle Contraction Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein N-linked Glycosylation Ventricular Cardiac Muscle Cell Action Potential Regulation Of Muscle Contraction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Positive Regulation Of Intracellular Transport Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Transport Dolichol-linked Oligosaccharide Biosynthetic Process Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Protein Glycosylation Macromolecule Glycosylation Glycosylation Apoptotic Signaling Pathway Glucocorticoid Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Glycoprotein Biosynthetic Process Midbrain Development Carbohydrate Metabolic Process Regulation Of Intracellular Transport	Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cardiac Muscle Contraction Cellular Response To Drug Regulation Of Potassium Ion Transport Heart Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Striated Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Regulation Of Muscle Contraction Regulation Of Heart Contraction Potassium Ion Transmembrane Transport Positive Regulation Of Ion Transport Potassium Ion Transport Potassium Ion Export Across Plasma Membrane Negative Regulation Of Potassium Ion Export Muscle Contraction Muscle System Process Regulation Of Membrane Potential Regulation Of Heart Rate By Hormone Blood Circulation Regulation Of Actin Filament-based Process Regulation Of Ion Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Response To Drug Positive Regulation Of Cardiac Muscle Contraction Synaptic Transmission Regulation Of Ion Transport Peptidyl-histidine Phosphorylation Regulation Of Heart Rate By Chemical Signal Atrial Cardiac Muscle Cell To AV Node Cell Communication Atrial Cardiac Muscle Cell Action Potential Monovalent Inorganic Cation Transport Regulation Of Cellular Component Movement
Tagcloud ?		1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh1 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie	aetiology bazett bqtc echocardiographic hodges hqtc https karyotypes kcnh2 lectaction lqts milliseconds nct00624949 prolongation prs qt qtc reader s0001fli scn5a selectprotocol settled sid thrice ts turner u000099e uid unexplained
Tagcloud (Difference) ?		1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh1 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 shp src40 subfamilies superfamily underlie	aetiology bazett bqtc echocardiographic hodges hqtc https karyotypes lectaction lqts milliseconds nct00624949 prolongation prs qtc reader s0001fli scn5a selectprotocol settled sid thrice ts turner u000099e uid unexplained
Tagcloud (Intersection) ?		kcnh2 qt