CFL2 and SSH1

Number of citations of the paper that reports this interaction (PubMedID 12684437)
52

Data Source:
HPRD (in vivo)

		CFL2	SSH1
Description		cofilin 2	slingshot protein phosphatase 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytoskeleton Actin Cytoskeleton Nuclear Matrix Z Disc I Band Extracellular Exosome	Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Growth Cone Midbody Cell Leading Edge Cleavage Furrow Cell Projection Synapse
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Actin Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity
	Biological Process	Actin Filament Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Sarcomere Organization Muscle Cell Cellular Homeostasis Actin Filament Severing	Cell Morphogenesis Protein Dephosphorylation Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Synaptic Plasticity Regulation Of Protein Metabolic Process Cellular Response To ATP Excitatory Chemical Synaptic Transmission Positive Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Excitatory Postsynaptic Potential
Pathways
Drugs
Diseases		Nemaline myopathy
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Atrial fibrillation ( 29892015 30061737) Hip circumference adjusted for BMI ( 28552196) Liver enzyme levels (alanine transaminase) ( 33972514) Takayasu arteritis ( 33308445)	Brain morphology (MOSTest) ( 32665545) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean platelet volume ( 27863252) Platelet count ( 32888494)
Interacting Genes		12 interacting genes: ACTB ACTG1 CAP2 LIMK1 PDE4B POT1 RAB2A RNF4 SSH1 STK11 TRIM7 UBE2I	6 interacting genes: ACTB AKT1 CFL1 CFL2 CORO1B DSTN
Entrez ID		1073	54434
HPRD ID		03262	09486
Ensembl ID		ENSG00000165410	ENSG00000084112
Uniprot IDs		Q549N0 Q9Y281	Q8WYL5
PDB IDs		7M0G 7U8K
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Filament-based Process Regulation Of Transepithelial Transport Actin Cytoskeleton Organization Dense Body Morphogenesis Of A Polarized Epithelium Schaffer Collateral - CA1 Synapse Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Apical Junction Complex NuA4 Histone Acetyltransferase Complex Axonogenesis Regulation Of Synaptic Vesicle Endocytosis Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Recycling Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament-based Process Immune Response-regulating Signaling Pathway Maintenance Of Blood-brain Barrier Anatomical Structure Homeostasis Tissue Homeostasis Lamellipodium Multicellular Organismal-level Homeostasis Cytoplasm Cytoskeleton Organization Platelet Aggregation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Regulation Of Cytoskeleton Organization SUMO Conjugating Enzyme Activity Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Chromosome Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification Process Neuron Projection Morphogenesis Homotypic Cell-cell Adhesion Regulation Of Actin Filament Organization Cell Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Nucleotide Binding Regulation Of Norepinephrine Uptake Negative Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Cellular Component Organization	Actin Filament Fragmentation Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Actin Filament Severing Positive Regulation Of Protein Depolymerization Actin Filament-based Process Regulation Of Organelle Organization Positive Regulation Of Protein-containing Complex Disassembly Protein Depolymerization Glutamatergic Synapse Lamellipodium Actin Filament Binding Regulation Of Actin Filament Depolymerization Actin Polymerization Or Depolymerization Actin Filament Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Regulation Of Actin Cytoskeleton Organization Nitric-oxide Synthase Regulator Activity Actin Cytoskeleton Organization Regulation Of Protein Depolymerization Actin Binding Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Cell Motility Cellular Response To Ether Positive Regulation Of Cellular Component Organization Regulation Of Protein-containing Complex Disassembly Nuclear Matrix Regulation Of Cellular Component Organization Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Protein-containing Complex Disassembly Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Vesicle Response To Ether Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Positive Regulation Of Lamellipodium Organization Regulation Of Cellular Component Size Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Response To Growth Factor Extracellular Exosome Regulation Of Lamellipodium Organization Response To Epidermal Growth Factor Cytoskeleton Organization
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