CFL2 and LIMK1

Number of citations of the paper that reports this interaction (PubMedID 12684437)
52

Data Source:
HPRD (in vitro, in vivo)

		CFL2	LIMK1
Description		cofilin 2	LIM domain kinase 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytoskeleton Actin Cytoskeleton Nuclear Matrix Z Disc I Band Extracellular Exosome	Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Nuclear Speck Lamellipodium Cell Junction Cell Projection Neuron Projection Postsynapse Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Protein Serine Kinase Activity Ubiquitin Ligase Inhibitor Activity
	Biological Process	Actin Filament Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Sarcomere Organization Muscle Cell Cellular Homeostasis Actin Filament Severing	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stress Fiber Assembly Positive Regulation Of Axon Extension Axon Extension Positive Regulation Of Stress Fiber Assembly
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs
Drugs			Dabrafenib Fostamatinib
Diseases		Nemaline myopathy
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Atrial fibrillation ( 29892015 30061737) Hip circumference adjusted for BMI ( 28552196) Liver enzyme levels (alanine transaminase) ( 33972514) Takayasu arteritis ( 33308445)	Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		12 interacting genes: ACTB ACTG1 CAP2 LIMK1 PDE4B POT1 RAB2A RNF4 SSH1 STK11 TRIM7 UBE2I	31 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 DSCAM FBXO7 H1-1 HUNK LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SRPK1 SSH3 WASHC1 YWHAZ
Entrez ID		1073	3984
HPRD ID		03262	03210
Ensembl ID		ENSG00000165410	ENSG00000106683
Uniprot IDs		Q549N0 Q9Y281	P53667
PDB IDs		7M0G 7U8K	3S95 5HVJ 5HVK 5L6W 5NXC 6WLY 7ATS 7ATU 7B8W 8AAU
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Filament-based Process Regulation Of Transepithelial Transport Actin Cytoskeleton Organization Dense Body Morphogenesis Of A Polarized Epithelium Schaffer Collateral - CA1 Synapse Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Apical Junction Complex NuA4 Histone Acetyltransferase Complex Axonogenesis Regulation Of Synaptic Vesicle Endocytosis Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Recycling Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament-based Process Immune Response-regulating Signaling Pathway Maintenance Of Blood-brain Barrier Anatomical Structure Homeostasis Tissue Homeostasis Lamellipodium Multicellular Organismal-level Homeostasis Cytoplasm Cytoskeleton Organization Platelet Aggregation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Regulation Of Cytoskeleton Organization SUMO Conjugating Enzyme Activity Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Chromosome Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification Process Neuron Projection Morphogenesis Homotypic Cell-cell Adhesion Regulation Of Actin Filament Organization Cell Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Nucleotide Binding Regulation Of Norepinephrine Uptake Negative Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Cellular Component Organization	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Positive Regulation Of Cellular Component Organization Protein Kinase Activity Regulation Of Cellular Component Organization Kinase Activity Intracellular Signal Transduction Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Regulation Of Actin Filament-based Process Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling ATP Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Developmental Growth Nucleotide Binding Actin Cytoskeleton Organization Regulation Of Interleukin-6 Production Regulation Of Protein Localization To Nucleus Regulation Of Cytoskeleton Organization Actin Filament-based Process Cellular Response To Starvation Transferase Activity Regulation Of Growth Response To Growth Factor Negative Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Nutrient Levels Dendritic Spine Development Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Projection Organization Angiotensin Receptor Binding Protein Phosphorylation Regulation Of Receptor-mediated Endocytosis Response To Starvation Positive Regulation Of Cellular Component Biogenesis Phosphorylation Positive Regulation Of Growth Regulation Of Immune Response Regulation Of Organelle Organization Cellular Response To Nutrient Levels Regulation Of Phosphorus Metabolic Process Clathrin-coated Pit
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