LGALS4 and RRAS2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LGALS4	RRAS2
Gene Name		lectin, galactoside-binding, soluble, 4	related RAS viral (r-ras) oncogene homolog 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome
	Molecular Function	Carbohydrate Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Cell Adhesion	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		4 interactors: ARPC3 KIAA1549 MLH1 RRAS2	29 interactors: ACVR1 AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB LGALS4 MLLT4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		3960	22800
HPRD ID		03949	02518
Ensembl ID		ENSG00000171747	ENSG00000133818
Uniprot IDs		P56470 Q6FHZ4	B7Z5Z2 P62070
PDB IDs		1X50	2ERY
Enriched GO Terms of Interacting Partners?		Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Negative Regulation Of Mitotic Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Spindle Midzone Assembly Resolution Of Meiotic Recombination Intermediates Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Nuclear-transcribed MRNA Poly(A) Tail Shortening Cell Differentiation Isotype Switching Metaphase Plate Congression Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Establishment Of Chromosome Localization Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Arp2/3 Complex-mediated Actin Nucleation Reciprocal Meiotic Recombination B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cytoskeleton Organization Synapsis Mismatch Repair Homologous Chromosome Segregation Male Meiosis Actin Nucleation Immunoglobulin Production Regulation Of DNA Recombination Immune Response Oogenesis MRNA 3'-end Processing Meiotic Chromosome Segregation Spindle Assembly Signal Transduction	Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Metabolic Process Signal Transduction Response To Stimulus Signaling Cell Communication Positive Regulation Of Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Catalytic Activity Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Hydrolase Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Response To Growth Factor Regulation Of Intracellular Signal Transduction Endothelial Cell Differentiation Positive Regulation Of Catalytic Activity Regulation Of Cell Death Endothelium Development Regulation Of Cellular Protein Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Regulation Of GTPase Activity Response To Stress Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Cell Death Positive Regulation Of Rap GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Bone Mineralization Defense Response BMP Signaling Pathway Regulation Of Cytokine Production Regulation Of Ras GTPase Activity Regulation Of Protein Localization
Tagcloud ?		adenocarcinoma adenocarcinomas concurrent deregulated describing epigenetically galactoside groundwork humanmethylation27 hypermethylated hypomethylated identifying illumina indicates infinium integrating kras lays lesser lung methylation modest never pairs platform showing smokers unsupervised verification
Tagcloud (Difference) ?		adenocarcinoma adenocarcinomas concurrent deregulated describing epigenetically galactoside groundwork humanmethylation27 hypermethylated hypomethylated identifying illumina indicates infinium integrating kras lays lesser lung methylation modest never pairs platform showing smokers unsupervised verification
Tagcloud (Intersection) ?