UCN and CRHBP

Number of citations of the paper that reports this interaction (PubMedID 8612563)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		UCN	CRHBP
Description		urocortin	corticotropin releasing hormone binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Axon Dendrite Neuronal Cell Body Varicosity Perikaryon Axon Terminus	Extracellular Region Extracellular Space Nucleus Secondary Lysosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Microtubule Secretory Granule Dendrite Dense Core Granule Varicosity Perikaryon Axon Terminus
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Histone Deacetylase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding	Protein Binding Peptide Binding Corticotropin-releasing Hormone Binding
	Biological Process	Startle Response Response To Oxidative Stress G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Sensory Perception Of Sound Learning Or Memory Feeding Behavior Associative Learning Aerobic Respiration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Auditory Stimulus Positive Regulation Of Cell Growth Neuron Projection Development Negative Regulation Of Appetite Response To Estradiol Positive Regulation Of Interleukin-6 Production Positive Regulation Of Collagen Biosynthetic Process Social Behavior Vasodilation Drinking Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Positive Regulation Of DNA Replication Negative Regulation Of Blood Pressure Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Response To Pain Response To Glucocorticoid Positive Regulation Of Corticotropin Secretion Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cardiac Muscle Contraction Positive Regulation Of Calcium Ion Import Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Feeding Behavior Positive Regulation Of Behavioral Fear Response	Synaptic Transmission, Dopaminergic Maternal Aggressive Behavior Inflammatory Response Signal Transduction Female Pregnancy Learning Or Memory Hormone-mediated Signaling Pathway Cellular Response To Potassium Ion Hormone Metabolic Process Regulated Exocytosis Behavioral Response To Ethanol Regulation Of Corticotropin Secretion Negative Regulation Of Corticotropin Secretion Cellular Response To Calcium Ion Cellular Response To Cocaine Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Xenobiotic Stimulus Regulation Of Cellular Response To Stress Cellular Response To Gonadotropin-releasing Hormone Negative Regulation Of Corticotropin-releasing Hormone Receptor Activity Regulation Of NMDA Receptor Activity
Pathways		Class B/2 (Secretin family receptors) Synthesis, secretion, and deacylation of Ghrelin	Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Crohn's disease ( 23128233)	Blood protein levels ( 30072576) Chronotype ( 30696823) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)
Interacting Genes		4 interacting genes: CRHBP CRHR1 CRHR2 LEP	2 interacting genes: ERRFI1 UCN
Entrez ID		7349	1393
HPRD ID		02970	08348
Ensembl ID		ENSG00000163794	ENSG00000145708
Uniprot IDs		P55089	P24387
PDB IDs		2RMF 3N96 6PB0 6PB1 7TRY 7TS0
Enriched GO Terms of Interacting Partners?		Cellular Response To Peptide Hormone Stimulus Corticotropin-releasing Hormone Binding Corticotropin-releasing Hormone Receptor Activity Corticotrophin-releasing Factor Receptor Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Corticotropin-releasing Hormone Stimulus Female Pregnancy Behavioral Response To Ethanol Hormone-mediated Signaling Pathway Adult Behavior Response To Hormone Cellular Response To Oxygen-containing Compound Regulation Of Hormone Secretion G Protein-coupled Peptide Receptor Activity Negative Regulation Of Peptide Secretion Axon Terminus Secretion By Cell Negative Regulation Of Transport Negative Regulation Of Hormone Secretion Peptide Hormone Secretion Peptide Secretion Negative Regulation Of Corticotropin Secretion Secretion Regulation Of Transmembrane Transporter Activity Negative Regulation Of Corticotropin-releasing Hormone Receptor Activity Secondary Lysosome Regulation Of Hormone Levels Regulation Of Monoatomic Ion Transmembrane Transporter Activity Hormone Secretion Activation Of Protein Kinase C Activity Positive Regulation Of Fat Cell Apoptotic Process Cellular Response To L-ascorbic Acid Negative Regulation Of Glutamine Transport Peptide Transport Regulation Of System Process Regulation Of Secretion By Cell Hormone Transport Response To Estradiol Negative Regulation Of Transmembrane Transport Regulation Of Secretion Corticotropin Secretion Regulation Of Lipoprotein Lipid Oxidation Regulation Of Fat Cell Apoptotic Process Amide Transport Negative Regulation Of Secretion By Cell Negative Regulation Of Glucagon Secretion Signal Release Signal Transduction Negative Regulation Of Secretion	Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Response To Methotrexate Dihydrofolate Reductase Activity Transport Of Viral Material Towards Nucleus Intracellular Transport Of Viral Protein In Host Cell Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Response To Estradiol Histone Deacetylase Inhibitor Activity Response To Glucocorticoid Response To Corticosteroid Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Dihydrofolate Metabolic Process Folic Acid Binding Folic Acid-containing Compound Biosynthetic Process Alcohol Metabolic Process Tetrahydrofolate Biosynthetic Process Tetrahydrobiopterin Metabolic Process Regulation Of Removal Of Superoxide Radicals Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Folic Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Host Cell Intracellular Transport Of Virus Secretory Vesicle Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Corticotropin Secretion Positive Regulation Of Behavioral Fear Response Varicosity Positive Regulation Of Fear Response Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Appetite Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Behavioral Fear Response Regulation Of Corticotropin Secretion Regulation Of Muscle System Process Negative Regulation Of Cell Size Negative Regulation Of Feeding Behavior Corticotropin-releasing Hormone Receptor 2 Binding Drinking Behavior Response To Steroid Hormone Negative Regulation Of Protein Autophosphorylation Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Oviduct Epithelium Development Lung Vasculature Development Limb Joint Morphogenesis
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