UCN and CRHBP

Number of citations of the paper that reports this interaction (PMID 8612563)
27

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		UCN	CRHBP
Gene Name		urocortin	corticotropin releasing hormone binding protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Dendrite Varicosity Perikaryon Axon Terminus	Extracellular Space Intracellular Nucleus Secondary Lysosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Microtubule Secretory Granule Dendrite Dense Core Granule Varicosity Perikaryon Axon Terminus
	Molecular Function	Neuropeptide Hormone Activity Protein Binding Histone Deacetylase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding	Protein Binding Peptide Binding Corticotropin-releasing Hormone Binding
	Biological Process	Inflammatory Response Response To Oxidative Stress G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Sensory Perception Of Sound Associative Learning Aerobic Respiration Negative Regulation Of Gene Expression Pancreatic Juice Secretion Positive Regulation Of Cell Growth Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Histone Deacetylation Neuron Projection Development Negative Regulation Of Appetite Response To Estradiol Positive Regulation Of Interleukin-6 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Activation Of Protein Kinase A Activity Social Behavior Gastric Emptying Drinking Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Positive Regulation Of Translation Positive Regulation Of DNA Replication Negative Regulation Of Blood Pressure Negative Regulation Of Cell Size Positive Regulation Of Vasodilation Negative Regulation Of Hormone Secretion Response To Pain Response To Glucocorticoid Positive Regulation Of Corticotropin Secretion Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Gastric Acid Secretion Negative Regulation Of Necrotic Cell Death Positive Regulation Of Calcium Ion Import Negative Regulation Of Neuron Death Negative Regulation Of Feeding Behavior Positive Regulation Of Behavioral Fear Response	Synaptic Transmission, Dopaminergic Maternal Aggressive Behavior Inflammatory Response Signal Transduction Female Pregnancy Learning Or Memory Hormone-mediated Signaling Pathway Cellular Response To Stress Cellular Response To Drug Cellular Response To Potassium Ion Hormone Metabolic Process Regulated Secretory Pathway Behavioral Response To Ethanol Regulation Of Corticotropin Secretion Negative Regulation Of Corticotropin Secretion Cellular Response To Calcium Ion Cellular Response To Cocaine Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Gonadotropin-releasing Hormone Negative Regulation Of Corticotropin-releasing Hormone Receptor Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 23128233)
Protein-Protein Interactions		4 interactors: CRHBP CRHR1 CRHR2 LEP	1 interactors: UCN
Entrez ID		7349	1393
HPRD ID		02970	08348
Ensembl ID			ENSG00000145708
Uniprot IDs		P55089	P24387
PDB IDs		2RMF 3N96
Enriched GO Terms of Interacting Partners?		Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Hormone Secretion Response To Peptide Hormone Response To Peptide Cellular Response To Hormone Stimulus Negative Regulation Of Secretion By Cell Adult Behavior Behavioral Response To Ethanol Response To Organonitrogen Compound Negative Regulation Of Secretion Response To Hormone Female Pregnancy Regulation Of Hormone Secretion Regulation Of Hormone Levels Negative Regulation Of Signaling Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of Transport Negative Regulation Of Peptide Secretion Response To Cocaine Single-organism Behavior Cellular Response To Organonitrogen Compound Secretion By Cell Cellular Response To Organic Substance Peptide Hormone Secretion Peptide Secretion Behavior Regulation Of Ion Transport Secretion Hormone Secretion Regulation Of Secretion Hormone Transport Response To Ammonium Ion Regulation Of Lipid Transport Peptide Transport Negative Regulation Of Ion Transport Response To Organic Substance Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Corticotropin Secretion Cellular Response To L-ascorbic Acid Negative Regulation Of Corticotropin-releasing Hormone Receptor Activity Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport General Adaptation Syndrome, Behavioral Process Amide Transport Hormone-mediated Signaling Pathway Response To Organic Cyclic Compound Response To Ethanol Regulation Of Ion Transmembrane Transporter Activity Cell-cell Signaling	Gastric Emptying Positive Regulation Of Corticotropin Secretion Regulation Of Corticotropin Secretion Negative Regulation Of Histone Deacetylation Negative Regulation Of Gastric Acid Secretion Pancreatic Juice Secretion Positive Regulation Of Cardiac Muscle Contraction Regulation Of Gastric Acid Secretion Negative Regulation Of Feeding Behavior Drinking Behavior Positive Regulation Of Behavioral Fear Response Negative Regulation Of Appetite Positive Regulation Of Striated Muscle Contraction Positive Regulation Of Vascular Permeability Regulation Of Feeding Behavior Positive Regulation Of Calcium Ion Import Activation Of Protein Kinase A Activity Negative Regulation Of Cell Size Negative Regulation Of Necrotic Cell Death Regulation Of Response To Food Regulation Of Appetite Regulation Of Calcium Ion Import Regulation Of Necrotic Cell Death Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Positive Regulation Of Heart Contraction Regulation Of Vascular Permeability Positive Regulation Of Vasodilation Regulation Of Histone Deacetylation Regulation Of Collagen Metabolic Process Response To Pain Social Behavior Regulation Of Vasodilation Negative Regulation Of Blood Pressure Regulation Of Protein Deacetylation Aerobic Respiration Positive Regulation Of CAMP Biosynthetic Process Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Hormone Secretion Positive Regulation Of DNA Replication Positive Regulation Of Interleukin-6 Production Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Translation Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Associative Learning Positive Regulation Of Cyclic Nucleotide Metabolic Process
Tagcloud ?		agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 ucn3 urocortins vasodilation
Tagcloud (Difference) ?		agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 ucn3 urocortins vasodilation
Tagcloud (Intersection) ?