UCN and CRHR2

Number of citations of the paper that reports this interaction (PubMedID 11416224)
40

Data Source:
HPRD (in vitro, in vivo)

		UCN	CRHR2
Description		urocortin	corticotropin releasing hormone receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Axon Dendrite Neuronal Cell Body Varicosity Perikaryon Axon Terminus	Plasma Membrane Membrane Dendrite Axon Terminus
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Histone Deacetylase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity
	Biological Process	Startle Response Response To Oxidative Stress G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Sensory Perception Of Sound Learning Or Memory Feeding Behavior Associative Learning Aerobic Respiration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Auditory Stimulus Positive Regulation Of Cell Growth Neuron Projection Development Negative Regulation Of Appetite Response To Estradiol Positive Regulation Of Interleukin-6 Production Positive Regulation Of Collagen Biosynthetic Process Social Behavior Vasodilation Drinking Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Positive Regulation Of DNA Replication Negative Regulation Of Blood Pressure Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Response To Pain Response To Glucocorticoid Positive Regulation Of Corticotropin Secretion Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cardiac Muscle Contraction Positive Regulation Of Calcium Ion Import Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Feeding Behavior Positive Regulation Of Behavioral Fear Response	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways		Class B/2 (Secretin family receptors) Synthesis, secretion, and deacylation of Ghrelin	G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Crohn's disease ( 23128233)	Type 2 diabetes ( 24509480 30297969)
Interacting Genes		4 interacting genes: CRHBP CRHR1 CRHR2 LEP	7 interacting genes: APP CRH GPR35 MALL UCN UCN2 UCN3
Entrez ID		7349	1395
HPRD ID		02970	03614
Ensembl ID		ENSG00000163794	ENSG00000106113
Uniprot IDs		P55089	A0A090N7T4 Q13324
PDB IDs		2RMF 3N96 6PB0 6PB1 7TRY 7TS0	3N93 3N95 3N96 6PB1 7TRY 7TS0
Enriched GO Terms of Interacting Partners?		Cellular Response To Peptide Hormone Stimulus Corticotropin-releasing Hormone Binding Corticotropin-releasing Hormone Receptor Activity Corticotrophin-releasing Factor Receptor Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Corticotropin-releasing Hormone Stimulus Female Pregnancy Behavioral Response To Ethanol Hormone-mediated Signaling Pathway Adult Behavior Response To Hormone Cellular Response To Oxygen-containing Compound Regulation Of Hormone Secretion G Protein-coupled Peptide Receptor Activity Negative Regulation Of Peptide Secretion Axon Terminus Secretion By Cell Negative Regulation Of Transport Negative Regulation Of Hormone Secretion Peptide Hormone Secretion Peptide Secretion Negative Regulation Of Corticotropin Secretion Secretion Regulation Of Transmembrane Transporter Activity Negative Regulation Of Corticotropin-releasing Hormone Receptor Activity Secondary Lysosome Regulation Of Hormone Levels Regulation Of Monoatomic Ion Transmembrane Transporter Activity Hormone Secretion Activation Of Protein Kinase C Activity Positive Regulation Of Fat Cell Apoptotic Process Cellular Response To L-ascorbic Acid Negative Regulation Of Glutamine Transport Peptide Transport Regulation Of System Process Regulation Of Secretion By Cell Hormone Transport Response To Estradiol Negative Regulation Of Transmembrane Transport Regulation Of Secretion Corticotropin Secretion Regulation Of Lipoprotein Lipid Oxidation Regulation Of Fat Cell Apoptotic Process Amide Transport Negative Regulation Of Secretion By Cell Negative Regulation Of Glucagon Secretion Signal Release Signal Transduction Negative Regulation Of Secretion	Corticotropin-releasing Hormone Receptor 2 Binding Varicosity Positive Regulation Of CAMP/PKA Signal Transduction Hormone Activity Corticotropin-releasing Hormone Receptor Binding Regulation Of CAMP/PKA Signal Transduction Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Calcium Ion Transport Positive Regulation Of Corticotropin Secretion G Protein-coupled Receptor Binding Positive Regulation Of Behavioral Fear Response Regulation Of Corticotropin Secretion Positive Regulation Of Fear Response Associative Learning G Protein-coupled Receptor Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Behavioral Fear Response Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Signaling Receptor Binding Regulation Of Monoatomic Ion Transport Response To Corticosterone Response To Glucocorticoid Response To Pain Perikaryon Hormone-mediated Signaling Pathway Positive Regulation Of Hormone Secretion Response To Auditory Stimulus Response To Corticosteroid Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Response To Immobilization Stress Positive Regulation Of Calcium Ion Import Positive Regulation Of Behavior Digestion Neuropeptide Hormone Activity Regulation Of Peptide Hormone Secretion Response To Steroid Hormone Response To Mineralocorticoid Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Calcium Ion Import Negative Regulation Of Blood Pressure Learning Or Memory Positive Regulation Of Secretion By Cell Regulation Of Transport Axon Terminus Cognition Positive Regulation Of Establishment Of Protein Localization
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