ABCC9 and STX1A

Number of citations of the paper that reports this interaction (PMID 15339904)
12

Data Source:
HPRD (in vitro)

		ABCC9	STX1A
Gene Name		ATP-binding cassette, sub-family C (CFTR/MRP), member 9	syntaxin 1A (brain)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex ATP-sensitive Potassium Channel Complex Sarcomere Sarcolemma	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane SNARE Complex Actomyosin Neuron Projection Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
	Molecular Function	Transporter Activity Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity Potassium Channel Regulator Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Ion Channel Binding	SNARE Binding Glycoprotein Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Myosin Head/neck Binding ATP-dependent Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Potassium Ion Transport Signal Transduction Synaptic Transmission Metabolic Process Potassium Ion Import Defense Response To Virus Transmembrane Transport	Positive Regulation Of Neurotransmitter Secretion Energy Reserve Metabolic Process Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Gravity Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Secretion By Cell Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Exocytosis Vesicle Docking Regulation Of Insulin Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		Inwardly rectifying K+ channels ABC-family proteins mediated transport ATP sensitive Potassium channels Potassium Channels	Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Insulin processing Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Transmission across Chemical Synapses
Drugs		Adenosine triphosphate Glyburide
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: EEF1G KCNJ11 KCNJ8 LDHA STX1A	58 interactors: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEPT2 SEPT5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS18
Entrez ID		10060	6804
HPRD ID		03258	01721
Ensembl ID		ENSG00000069431	ENSG00000106089
Uniprot IDs		O60706	A8MZ54 Q16623 Q75ME0
PDB IDs
Enriched GO Terms of Interacting Partners?		Potassium Ion Import Generation Of Precursor Metabolites And Energy Synaptic Transmission Energy Reserve Metabolic Process Cell-cell Signaling Potassium Ion Transmembrane Transport Regulation Of Insulin Secretion Potassium Ion Transport Regulation Of Peptide Hormone Secretion Response To Virus Regulation Of Hormone Secretion Regulation Of Membrane Potential Cellular Response To Nicotine Energy Derivation By Oxidation Of Organic Compounds Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Fusion To Presynaptic Membrane Oxidation-reduction Process Regulation Of Protein Secretion Regulation Of Ion Transmembrane Transport Response To Gravity Positive Regulation Of Neurotransmitter Secretion Ion Transport Response To External Stimulus Response To Stimulus Glutamate Secretion Response To ATP Regulation Of Ion Transport Regulation Of Protein Transport Positive Regulation Of Cation Channel Activity Regulation Of Secretion Vasodilation Response To Ischemia Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Synaptic Vesicle Exocytosis Monovalent Inorganic Cation Transport Response To PH Regulation Of Establishment Of Protein Localization Response To Testosterone Substantia Nigra Development Response To Nicotine Cellular Response To Alkaloid Small Molecule Metabolic Process Negative Regulation Of Insulin Secretion Response To Other Organism Regulation Of Synaptic Vesicle Transport Positive Regulation Of Membrane Potential Positive Regulation Of Transport Negative Regulation Of Peptide Secretion Response To Biotic Stimulus	Exocytosis Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Regulation Of Neurotransmitter Levels Transport Vesicle-mediated Transport Regulation Of Secretion Neurotransmitter Secretion Synaptic Transmission Cell-cell Signaling Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Localization Membrane Fusion Glutamate Secretion Establishment Of Vesicle Localization Vesicle Localization Ion Transport Vesicle Fusion Protein Transport Establishment Of Protein Localization Amino Acid Transport Vesicle Docking Organelle Fusion Membrane Docking Establishment Of Organelle Localization Membrane Organization Acid Secretion Vesicle Organization Positive Regulation Of Secretion Organelle Localization Protein Localization Monovalent Inorganic Cation Transport Anion Transport Dicarboxylic Acid Transport Regulated Secretory Pathway Metal Ion Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Sodium Ion Transport Organic Anion Transport
Tagcloud ?		annually arid1a causing chd4 comprehensively deadliest deaths disruption endometrial enriched ep300 etiology exome fbxw7 frequencies grouping implicating ligase map3k4 mutated mutational remodeling resequenced serous sixth somatic spop tspyl2 worldwide	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Difference) ?		annually arid1a causing chd4 comprehensively deadliest deaths disruption endometrial enriched ep300 etiology exome fbxw7 frequencies grouping implicating ligase map3k4 mutated mutational remodeling resequenced serous sixth somatic spop tspyl2 worldwide	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Intersection) ?