ABCC9 and STX1A

Number of citations of the paper that reports this interaction (PubMedID 15339904)
0

Data Source:
HPRD (in vitro)

		ABCC9	STX1A
Description		ATP binding cassette subfamily C member 9	syntaxin 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Plasma Membrane Inward Rectifying Potassium Channel Membrane Sarcomere Potassium Ion-transporting ATPase Complex Protein-containing Complex Sarcolemma	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Endomembrane System Membrane Secretory Granule Axon Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Actomyosin Presynaptic Membrane Neuron Projection Synapse Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity Potassium Channel Regulator Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Transmembrane Transporter Binding Protein-containing Complex Binding Potassium Channel Activator Activity ABC-type Transporter Activity	SNARE Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein-macromolecule Adaptor Activity Myosin Head/neck Binding Identical Protein Binding ATP-dependent Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Calcium-dependent Protein Binding
	Biological Process	MAPK Cascade Action Potential Blood Vessel Development Response To Hypoxia Heart Morphogenesis Vascular Process In Circulatory System Regulation Of Transcription By RNA Polymerase II Potassium Ion Transport Response To Stress Mitochondrion Organization Heart Development Skeletal Muscle Tissue Development Blood Circulation Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Response To Activity Fatty Acid Oxidation Response To ATP Response To Potassium Ion Cellular Response To Potassium Ion Response To Decreased Oxygen Levels Vasodilation Regulation Of Membrane Potential Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Response To Estrogen Cellular Respiration Negative Regulation Of Blood Pressure ATP Metabolic Process Fibroblast Proliferation Defense Response To Virus Transmembrane Transport Coronary Vasculature Development Cardiac Conduction Cellular Response To Chemical Stress Response To Oxygen Levels Cellular Response To Calcium Ion Cellular Response To ATP Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Circulatory System Development Oxygen Metabolic Process Cardiac Muscle Cell Contraction Blood Vessel Diameter Maintenance Monoatomic Cation Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Cation Transmembrane Transport Transport Across Blood-brain Barrier Regulation Of Potassium Ion Transmembrane Transport Response To Peptide Reactive Oxygen Species Biosynthetic Process Response To Hydrogen Sulfide Potassium Ion Import Across Plasma Membrane	Positive Regulation Of Neurotransmitter Secretion Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Response To Gravity Positive Regulation Of Norepinephrine Secretion Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Vesicle-mediated Transport Protein Sumoylation Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Secretion By Cell Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Regulated Exocytosis Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Hormone Secretion Vesicle Docking Synaptic Vesicle Endocytosis Regulation Of Insulin Secretion Protein Localization To Membrane Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		ATP sensitive Potassium channels ABC-family proteins mediated transport Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (botC) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea
Drugs		ATP Glyburide Nicorandil
Diseases		Atrial fibrillation
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 27680694) Gout ( 22179738) Hippocampal sclerosis of aging ( 24770881) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 30224653 30578418)	Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: EEF1G HSPB2 KCNJ11 KCNJ8 LDHA STX1A	169 interacting genes: AARD ABCC9 ABI3 AGTRAP AIG1 ANKRD46 AOC3 APBA1 APOL2 APOL3 AQP3 ARL13B ARLN ATP4B ATP6V1B1 BET1 BLOC1S6 BNIP1 BTN2A2 C1GALT1 CACNA1D CCSER2 CD81 CDC37 CDK5 CFTR CLEC1A CLN6 CMTM7 CPLX1 CSNK2A1 CSNK2A2 CXCL16 CYB5B DAPK1 DDX49 DSCR9 DYRK1A EBAG9 EMD ERG28 ETNK2 FAM3C GIMAP1 GIMAP5 GOLM2 GOSR2 GPM6B HMOX1 JAGN1 KCNB1 KIFC3 MAL MALL MIP MMGT1 NAPA NAPB NINJ2 NKG7 NRM NSF PGAP2 PLN PLP1 PLPP4 PLPP6 PNLIPRP1 PSMA3 RAB27A RAB3IL1 RIMS1 RMDN2 RNF4 RTP2 SCNN1A SCNN1B SCNN1G SDCBP SEC22A SEC22B SEPTIN2 SEPTIN5 SERP1 SERP2 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SMIM1 SMIM3 SNAP23 SNAP25 SNAP29 SNAP47 SNORC SNPH STRIT1 STX10 STX11 STX12 STX16 STX2 STX3 STX4 STX5 STX6 STX7 STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TCEANC TMEM100 TMEM120A TMEM128 TMEM14C TMEM222 TMEM254 TMEM41A TMEM60 TNF TRAF3IP3 TRDMT1 TSGA10IP TSNARE1 TXLNA TXLNB UBE2I UBTFL1 UNC13B UPK1B USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VIM VMA12 VPS11 VPS16 VPS18 VSTM4 VTI1B ZFPL1 ZNF12 ZNF136 ZNF250 ZNF440 ZNF441 ZNF479 ZNF490 ZNF557 ZNF696 ZNF707 ZNF785 ZNF835
Entrez ID		10060	6804
HPRD ID		03258	01721
Ensembl ID		ENSG00000069431	ENSG00000106089
Uniprot IDs		O60706	A0A0C4DFZ1 A8MZ54 Q16623 Q75ME0
PDB IDs
Enriched GO Terms of Interacting Partners?		Inward Rectifying Potassium Channel Response To Resveratrol ATP-activated Inward Rectifier Potassium Channel Activity CAMKK-AMPK Signaling Cascade Response To Stilbenoid Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ventricular Cardiac Muscle Tissue Development Inward Rectifier Potassium Channel Activity Regulation Of Presynaptic Membrane Potential Presynaptic Active Zone Membrane Response To ATP Determination Of Adult Lifespan Potassium Ion Import Across Plasma Membrane Response To Ischemia Cardiac Muscle Tissue Development Atrioventricular Node Cell Differentiation Myosin Head/neck Binding Voltage-gated Potassium Channel Complex Regulation Of Membrane Potential Inorganic Cation Import Across Plasma Membrane Neurotransmitter Transport Protein Localization To Extracellular Region Potassium Ion-transporting ATPase Complex Synaptic Assembly At Neuromuscular Junction Striated Muscle Tissue Development Cardiac Pacemaker Cell Differentiation Action Potential Establishment Of Protein Localization To Extracellular Region Protein Secretion Sulfonylurea Receptor Binding Monoatomic Ion Channel Complex Glutamate Secretion, Neurotransmission Glucose Metabolic Process Lactate Dehydrogenase Activity Glucose Catabolic Process To Lactate Via Pyruvate Asymmetric Neuroblast Division Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Transmembrane Transporter Binding Somatic Muscle Development Import Across Plasma Membrane Potassium Ion Transmembrane Transport Import Into Cell Response To Purine-containing Compound Muscle Tissue Development L-lactate Dehydrogenase (NAD+) Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Calcium-mediated Signaling	SNAP Receptor Activity SNARE Complex Membrane Fusion Organelle Localization By Membrane Tethering Organelle Membrane Fusion Syntaxin Binding Vesicle Fusion Membrane Docking Vesicle Docking Organelle Fusion SNARE Binding Vesicle Organization Membrane Organization Vesicle-mediated Transport Exocytosis Secretion By Cell Membrane Syntaxin-1 Binding Secretion Establishment Of Localization In Cell Establishment Of Protein Localization Organelle Localization Protein Transport Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Endomembrane System Cellular Localization Intracellular Protein Localization SNARE Complex Assembly Neurotransmitter Transport Positive Regulation Of Exocytosis Regulated Exocytosis Regulation Of Secretion By Cell Calcium-ion Regulated Exocytosis Synaptic Vesicle Priming Regulation Of Regulated Secretory Pathway Regulation Of Secretion Intracellular Protein Transport Intracellular Transport Golgi Vesicle Transport Signal Release Synaptic Vesicle Exocytosis Positive Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Presynapse Regulation Of Transport Vesicle-mediated Transport In Synapse Chloride Channel Inhibitor Activity
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