BST1 and CAV1

Number of citations of the paper that reports this interaction (PMID 11866528)
11

Data Source:
HPRD (in vivo)

		BST1	CAV1
Gene Name		bone marrow stromal cell antigen 1	caveolin 1, caveolae protein, 22kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome	Golgi Membrane Acrosomal Membrane Intracellular Endosome Endoplasmic Reticulum Lipid Particle Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Cilium Cell Cortex Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	NAD+ Nucleosidase Activity Transferase Activity Phosphorus-oxygen Lyase Activity NAD(P)+ Nucleosidase Activity	Receptor Binding Patched Binding Structural Molecule Activity Protein Binding Cholesterol Binding Peptidase Activator Activity Enzyme Binding Protein Kinase Binding Protein Complex Scaffold Identical Protein Binding Ion Channel Binding Nitric-oxide Synthase Binding Inward Rectifier Potassium Channel Inhibitor Activity
	Biological Process	Humoral Immune Response Multicellular Organismal Development Metabolic Process Positive Regulation Of B Cell Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Inactivation Of MAPK Activity Angiogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Response To Ischemia Regulation Of The Force Of Heart Contraction By Chemical Signal Triglyceride Metabolic Process Calcium Ion Transport Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Skeletal Muscle Tissue Development Lactation Blood Coagulation Protein Localization Cellular Response To Starvation Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Peptidase Activity Viral Process Vesicle Organization Regulation Of Fatty Acid Metabolic Process Lipid Storage Regulation Of Blood Coagulation Cholesterol Transport Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Maintenance Of Protein Location In Cell Response To Progesterone Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Nitric Oxide Homeostasis Vasoconstriction Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Cholesterol Homeostasis Negative Regulation Of MAPK Cascade Response To Estrogen Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Vasoconstriction Nitric Oxide Metabolic Process Negative Regulation Of JAK-STAT Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Metalloenzyme Activity Leukocyte Migration Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Cytosolic Calcium Ion Homeostasis Response To Calcium Ion Membrane Depolarization Regulation Of Peptidase Activity Calcium Ion Homeostasis Mammary Gland Involution Negative Regulation Of Protein Tyrosine Kinase Activity Caveola Assembly Cellular Response To Hyperoxia Caveolin-mediated Endocytosis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Membrane Repolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Inward Rectifier Potassium Channel Activity Protein Localization To Basolateral Plasma Membrane Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Anoikis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Metabolism of lipids and lipoproteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Lipid digestion, mobilization, and transport Signaling by Wnt Basigin interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall eNOS activation disassembly of the destruction complex and recruitment of AXIN to the membrane Metabolism of nitric oxide Signaling by VEGF TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis NOSTRIN mediated eNOS trafficking VEGFR2 mediated vascular permeability XAV939 inhibits tankyrase, stabilizing AXIN eNOS activation and regulation Signaling by WNT in cancer
Drugs		Adenosine-5\'-Diphosphate Monothiophosphate Etheno-Nad Nicotinamide Nicotinamide Mononucleotide Etheno-Nadp
Diseases
GWAS		Parkinson's disease ( 22451204 21084426 21292315 19915576)	Atrial fibrillation ( 22544366) Electrocardiographic traits ( 20062063) Glaucoma (primary open-angle) ( 20835238) PR interval ( 20062060 23139255)
Protein-Protein Interactions		2 interactors: CAV1 LBP	81 interactors: ABCB1 ABL1 ADRBK1 AKAP1 APP AR BMX BSG BST1 BTK CAV2 CD40 CSK CSNK2A1 CSNK2A2 DAG1 DNM1 EDNRB EGFR ERBB2 ESR1 FLNA FLOT2 FYN GJA1 GJA3 GJB2 GNAI2 GRB7 GRK1 GRK5 HRAS HTR1F IGF1R IGFBP3 ILK INSR IRS1 KDR LATS1 LRP1 MALL MAPK1 MAPK3 MMP14 NEU3 NGFR NOS2 NOS3 NTRK1 PDGFRA PDGFRB PLD1 PLD2 PPP1CA PPP2CA PRNP PTEN PTGS2 PTPN1 PTPN11 PTPN6 PTPRF RAC1 RCVRN RHOA RHOC S1PR1 SCP2 SNCA SOS1 SRC STOML3 STRN STRN4 TGFBR1 TNFRSF1B TRAF2 TRAF6 TRPC1 VCP
Entrez ID		683	857
HPRD ID		02665	03028
Ensembl ID		ENSG00000109743	ENSG00000105974
Uniprot IDs		Q10588 Q1XII0	A9XTE5 Q03135 Q2TNI1 Q59E85 Q7Z4F3
PDB IDs		1ISF 1ISG 1ISH 1ISI 1ISJ 1ISM
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Leukocyte Migration Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Lipopolysaccharide Transport Nitric Oxide Homeostasis Positive Regulation Of Cell Activation Lipid Transport Lipid Localization Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Inward Rectifier Potassium Channel Activity Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Pinocytosis Caveolin-mediated Endocytosis Protein Localization To Basolateral Plasma Membrane Mammary Gland Involution Regulation Of Cell Activation Protein Localization To Plasma Membrane Raft Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Metalloenzyme Activity Caveola Assembly Positive Regulation Of Respiratory Burst Regulation Of Cardiac Muscle Cell Action Potential Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Nitric-oxide Synthase Activity Cellular Response To Hyperoxia Endocytosis Membrane Raft Assembly Regulation Of Cellular Component Movement Opsonization Protein Localization To Membrane Raft Regulation Of Respiratory Burst Macrophage Activation Involved In Immune Response Negative Regulation Of Monooxygenase Activity Positive Regulation Of Macrophage Activation Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Detection Of Molecule Of Bacterial Origin Negative Regulation Of Anoikis Negative Regulation Of Nitric Oxide Biosynthetic Process Cell Migration Response To Lipid Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Leukocyte Migration Involved In Inflammatory Response Negative Regulation Of Protein Tyrosine Kinase Activity	Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Signal Transduction Locomotion Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Response To External Stimulus Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Regulation Of Cell Proliferation Regulation Of Phosphorylation Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Wound Healing Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To Wounding Positive Regulation Of Phosphorylation Cell Development Regulation Of Catalytic Activity Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Kinase Activity Regulation Of Body Fluid Levels Chemotaxis Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Catalytic Activity Blood Coagulation Anatomical Structure Development Hemostasis Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Tissue Development Intracellular Signal Transduction Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway System Development Neurotrophin Signaling Pathway Neuron Projection Morphogenesis Response To Stress Cell Morphogenesis Involved In Neuron Differentiation
Tagcloud ?		20e abca7 additive apoe associations calculate clu coded cr1 ethnic fail genotyped gwas hits korean koreans logistic lrrk2 overlapping park16 pd picalm rab7l1 replicated rs11931074 snca snps susceptibility top	17beta caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmr1 fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
Tagcloud (Difference) ?		20e abca7 additive apoe associations calculate clu coded cr1 ethnic fail genotyped gwas hits korean koreans logistic lrrk2 overlapping park16 pd picalm rab7l1 replicated rs11931074 snca snps susceptibility top	17beta caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmr1 fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
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