LBP and IRF6

Number of citations of the paper that reports this interaction (PMID 11544322)
33

Data Source:
BioGRID (pull down)

		LBP	IRF6
Gene Name		lipopolysaccharide binding protein	interferon regulatory factor 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Lipopolysaccharide Binding Receptor Binding Protein Binding Lipoteichoic Acid Binding	Regulatory Region DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Macrophage Activation Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis	Transcription, DNA-templated Cell Cycle Arrest Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Keratinocyte Differentiation Keratinocyte Proliferation Positive Regulation Of Transcription, DNA-templated Cell Development Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Mammary Gland Epithelial Cell Differentiation
Pathways		Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Innate Immune System	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Cleft lip ( 20436469) Orofacial clefts ( 19270707 22863734)
Protein-Protein Interactions		19 interactors: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 FTH1 HSPB1 IRF6 PRDX4 PSMA3 PYCRL RPS21 SETD1A SMAD3 TRA2A TSC22D4	5 interactors: IRF8 LBP RFX3 TLX2 ZBTB3
Entrez ID		3929	3664
HPRD ID		07175	06227
Ensembl ID		ENSG00000129988	ENSG00000117595
Uniprot IDs		P18428 Q8TCF0	G0Z349 O14896
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune System Process Immune Response Regulation Of Interleukin-1 Beta Production Regulation Of Cell Proliferation Humoral Immune Response Protein Stabilization Response To Stress Regulation Of Protein Stability Positive Regulation Of Interleukin-1 Beta Production Regulation Of Protein Catabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Immune System Process Posttranscriptional Regulation Of Gene Expression Regulation Of Immune Response Positive Regulation Of Stress Fiber Assembly Response To Stimulus Negative Regulation Of Protein Metabolic Process Positive Regulation Of Actin Filament Bundle Assembly Gene Expression Regulation Of Cytokine Production Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Male Germ Cell Proliferation Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Growth Of Symbiont On Or Near Host Surface Regulation Of Protein Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production I-kappaB Kinase/NF-kappaB Signaling Cell Cycle Process Regulation Of Stress Fiber Assembly Regulation Of Inflammatory Response Negative Regulation Of Cell Proliferation Regulation Of Opsonization Intracellular Sequestering Of Iron Ion Negative Regulation Of Interleukin-1 Beta Secretion Sister Chromatid Biorientation Response To Other Organism Positive Regulation Of Protein Metabolic Process Epithelial Cell Proliferation Intracellular Signal Transduction Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of Male Germ Cell Proliferation Evasion Or Tolerance Of Host Defenses By Virus Response To Biotic Stimulus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Metabolic Process Negative Regulation Of Inflammatory Response	Negative Regulation Of Growth Of Symbiont In Host Cellular Response To Lipopolysaccharide Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Type B Pancreatic Cell Maturation Lipopolysaccharide Transport Transcription, DNA-templated Cellular Response To Molecule Of Bacterial Origin RNA Biosynthetic Process Defense Response To Bacterium Cilium-dependent Cell Motility Positive Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Growth Phagocytosis Glandular Epithelial Cell Maturation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway RNA Metabolic Process Positive Regulation Of Respiratory Burst Response To Lipopolysaccharide Negative Regulation Of Dendrite Morphogenesis Response To Molecule Of Bacterial Origin Gene Expression Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Cilium Or Flagellum-dependent Cell Motility Positive Regulation Of Cytokine Production Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Opsonization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Respiratory Burst Macrophage Activation Involved In Immune Response Positive Regulation Of Macrophage Activation Macromolecule Biosynthetic Process Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of DNA-templated Transcription, Initiation Enteric Nervous System Development Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Detection Of Molecule Of Bacterial Origin Cellular Response To Lipid Regulation Of Metabolic Process Negative Regulation Of Dendrite Development Type B Pancreatic Cell Development Leukocyte Migration Involved In Inflammatory Response Regulation Of DNA-templated Transcription, Initiation Response To Bacterium Defense Response To Protozoan Regulation Of Tumor Necrosis Factor Biosynthetic Process
Tagcloud ?		adopt af agonists allowing apo bms614 competent constitutive corepressor der disabled disrupts h11 heterodimerization heterodimers holo maintains modelling ngfi pocket relieve rxr rxralpha rxralphaf318a shifting thermodynamic transcriptionally van waals	cd68 conceptus coordinately dialogue enjsrv ensures env estrous ewes exosomal exosomes flushings hsc70 ifnt interleukins irak1 irf7 jaagsiekte liberated oftlr otr1 ovine plasmacytoid proliferated retroviruses ruminants tlr trophectoderm uterine
Tagcloud (Difference) ?		adopt af agonists allowing apo bms614 competent constitutive corepressor der disabled disrupts h11 heterodimerization heterodimers holo maintains modelling ngfi pocket relieve rxr rxralpha rxralphaf318a shifting thermodynamic transcriptionally van waals	cd68 conceptus coordinately dialogue enjsrv ensures env estrous ewes exosomal exosomes flushings hsc70 ifnt interleukins irak1 irf7 jaagsiekte liberated oftlr otr1 ovine plasmacytoid proliferated retroviruses ruminants tlr trophectoderm uterine
Tagcloud (Intersection) ?