ZC3H10 and STAM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZC3H10	STAM2
Description		zinc finger CCCH-type containing 10	signal transducing adaptor molecule 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleoplasm Cytoplasm Endosome Cytosol Membrane Endocytic Vesicle Early Endosome Membrane ESCRT-0 Complex
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding MiRNA Binding Metal Ion Binding	Protein Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Post-transcriptional Regulation Of Gene Expression Regulation Of RNA Splicing Negative Regulation Of MiRNA Processing	Signal Transduction Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission
Pathways			EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Metabolic syndrome ( 31170924) Pulse pressure ( 30224653)
Interacting Genes		52 interacting genes: ACTMAP ALG13 AOC1 APPBP2 ARID5A ATXN1 BOLL C10orf55 CRX DAB1 DAZAP2 DMRTB1 ESRP1 FAM168B FOSB FOXH1 HIVEP1 INTS11 KLHDC7B KRTAP19-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LASP1 MIR143 MSX2 NCS1 NFYA OTX2 OXER1 PIAS2 PICALM PLA2G10 POU2F1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RBFOX2 RBM38 RBPMS RBPMS2 RNF4 SNRPA SPMIP9 STAM2 TENT5A TENT5B UBE2I ZNF34	37 interacting genes: ABI2 ARRDC3 ATXN1 CBX5 CDC7 DAZAP2 EGFR ENTREP1 EPS15 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF MAP3K1 PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN1 UBQLN4 USP8 VPS37C XRN1 ZC3H10
Entrez ID		84872	10254
HPRD ID		07860	05876
Ensembl ID		ENSG00000135482	ENSG00000115145
Uniprot IDs		Q96K80	O75886
PDB IDs			1X2Q 1X5B 2L0T 5CRV 5IXF
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Stabilization Negative Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process MRNA 3'-UTR Binding Regulation Of RNA Stability Regulation Of Primary Metabolic Process MRNA Binding Cytoplasmic Stress Granule Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA Binding Negative Regulation Of Macromolecule Metabolic Process Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Poly(A) RNA Polymerase Activity Positive Regulation Of Biosynthetic Process Regulation Of MRNA Processing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Intermediate Filament Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process RNA Binding Transcription Factor Binding SUMO Transferase Activity 3'-UTR-mediated MRNA Stabilization	Endosome Growth Hormone Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Early Endosome Proteolysis Cell Surface Receptor Signaling Pathway Via STAT Extrinsic Component Of Plasma Membrane Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Protein Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Protein K48-linked Ubiquitination Protein-containing Complex Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Signal Transduction Early Endosome Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Type II Interferon-mediated Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Cell Communication Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Interleukin-12 Receptor Complex Ubiquitin-protein Transferase Activity Protein Autoubiquitination Receptor Internalization Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Interleukin-23 Receptor Complex Cytosol Protein Polyubiquitination Endosome Membrane Regulation Of Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Proteasomal Protein Catabolic Process Interleukin-23-mediated Signaling Pathway Positive Regulation Of NK T Cell Proliferation CXCL12-activated CXCR4 Signaling Pathway
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