CLEC4D and ANKRD46

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLEC4D	ANKRD46
Description		C-type lectin domain family 4 member D	ankyrin repeat domain 46
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Membrane
	Molecular Function	Protein Binding D-mannose Binding Carbohydrate Binding Immunoglobulin Receptor Binding Pattern Recognition Receptor Activity Metal Ion Binding	Protein Binding
	Biological Process	Adaptive Immune Response T Cell Differentiation Involved In Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Activation Fc-gamma Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Antifungal Innate Immune Response
Pathways		Dectin-2 family Neutrophil degranulation
Drugs
Diseases
GWAS			Atrioventricular conduction ( 21041692) Body mass index ( 26426971) Percentage gas trapping ( 26030696)
Interacting Genes		4 interacting genes: ACTN2 ANKRD46 JAGN1 ZDHHC22	63 interacting genes: AMIGO1 APH1A AQP6 ARL13B BIK BSCL2 C16orf54 CD22 CD46 CLDN20 CLDN7 CLEC4D CRB3 CREB3L1 CXADR CYB561 EBP EFNB1 EFNB2 ELOVL4 FAM174A FAM209A FFAR2 GOLM1 GPR152 GPR42 GPX8 HSD17B11 HSD17B13 IFNLR1 KASH5 KIR2DL3 LAMTOR5 LDLRAD1 LRRC25 MFF MMGT1 MUC1 NCAPH2 NSG2 PLPP4 PVR RELL2 RETREG3 SCN3B SECTM1 SHISA3 SLC10A6 SLC16A2 SLC18A1 SLC39A9 ST6GALNAC6 STX1A STX2 STX4 SUSD3 THAP4 TIMMDC1 TMEM248 TMEM31 TMEM45B TMEM79 TMPRSS2
Entrez ID		338339	157567
HPRD ID		13074	14103
Ensembl ID		ENSG00000166527	ENSG00000186106
Uniprot IDs		Q8WXI8	B3KT99 Q86W74
PDB IDs		2LS8 3WHD
Enriched GO Terms of Interacting Partners?		Protein Localization To Plasma Membrane Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Protein Localization To Cell Periphery Channel Activator Activity Microspike Assembly Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping FATZ Binding Negative Regulation Of Protein Localization LIM Domain Binding Plasmacytoid Dendritic Cell Activation Negative Regulation Of Regulatory T Cell Differentiation Leukocyte Mediated Immunity MHC Class II Protein Binding Granulocyte Colony-stimulating Factor Signaling Pathway	Membrane Protein Binding Plasma Membrane Steroid Dehydrogenase Activity
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