CLEC4D and LAG3

Data Source: HiPPIP (Novel)

		CLEC4D	LAG3
Name		C-type lectin domain family 4 member D	lymphocyte activating 3
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding D-mannose Binding Carbohydrate Binding Immunoglobulin Receptor Binding Pattern Recognition Receptor Activity Metal Ion Binding	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding MHC Class II Protein Binding
	Biological Process	Adaptive Immune Response T Cell Differentiation Involved In Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Activation Fc-gamma Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Antifungal Innate Immune Response	Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production T Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Activation
Pathways		Dectin-2 family Neutrophil degranulation	MHC class II antigen presentation
Drugs		None	Relatlimab
GWAS		No GWAS studies recorded	Blood protein levels ( 30072576 )
Novel Interactors		1 novel interactors: LAG3	5 novel interactors: ALCAM CLEC4D GNAI2 KCNA1 UBE2E3
Interacting Genes		4 interacting genes: ACTN2 ANKRD46 JAGN1 ZDHHC22	2 interacting genes: CEBPZ CPAP
Entrez ID		338339	3902
HPRD ID		13074	01077
Ensembl ID		ENSG00000166527	ENSG00000089692
Uniprot IDs		Q8WXI8	P18627
PDB IDs		2LS8 3WHD	7TZG 7TZH 7UM3 8SO3 8SR0 9BF9
GO Terms Enriched among Interactors		Protein Localization To Plasma Membrane Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Protein Localization To Cell Periphery Channel Activator Activity Microspike Assembly Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping FATZ Binding Negative Regulation Of Protein Localization LIM Domain Binding Plasmacytoid Dendritic Cell Activation Negative Regulation Of Regulatory T Cell Differentiation Leukocyte Mediated Immunity MHC Class II Protein Binding Granulocyte Colony-stimulating Factor Signaling Pathway	None