CLEC4D and ZDHHC22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLEC4D	ZDHHC22
Description		C-type lectin domain family 4 member D	zDHHC palmitoyltransferase 22
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Protein Binding D-mannose Binding Carbohydrate Binding Immunoglobulin Receptor Binding Pattern Recognition Receptor Activity Metal Ion Binding	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity
	Biological Process	Adaptive Immune Response T Cell Differentiation Involved In Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Activation Fc-gamma Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Antifungal Innate Immune Response	Protein Targeting To Membrane Protein Palmitoylation Protein Localization To Plasma Membrane
Pathways		Dectin-2 family Neutrophil degranulation
Drugs
Diseases
GWAS			Cerebrospinal P-tau181p levels ( 28247064) Large artery stroke ( 24262325) Smoking status (ever vs never smokers) ( 30643258) Sweet taste preference ( 32572145)
Interacting Genes		4 interacting genes: ACTN2 ANKRD46 JAGN1 ZDHHC22	14 interacting genes: CD79A CLEC4D CLSTN3 CREB3L1 FCRL2 FNDC9 GPX8 LDLRAD4 PVR RPRM TMEM14B TMEM86B TMEM88 TRIM59
Entrez ID		338339	283576
HPRD ID		13074	12655
Ensembl ID		ENSG00000166527	ENSG00000177108
Uniprot IDs		Q8WXI8	Q8N966
PDB IDs		2LS8 3WHD
Enriched GO Terms of Interacting Partners?		Protein Localization To Plasma Membrane Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Protein Localization To Cell Periphery Channel Activator Activity Microspike Assembly Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping FATZ Binding Negative Regulation Of Protein Localization LIM Domain Binding Plasmacytoid Dendritic Cell Activation Negative Regulation Of Regulatory T Cell Differentiation Leukocyte Mediated Immunity MHC Class II Protein Binding Granulocyte Colony-stimulating Factor Signaling Pathway	Membrane
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