HERC4

Description		HECT and RLD domain containing E3 ubiquitin protein ligase 4
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Protein Ubiquitination Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 28892062)
Interacting Genes		7 interacting genes: HERC6 MAFA UBC UBE2D2 UBE2E3 UBE2J2 UBE2L3
Entrez ID		26091
HPRD ID		13646
Ensembl ID		ENSG00000148634
Uniprot IDs		Q5GLZ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Protein Modification Process Macromolecule Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Protein Metabolic Process Regulation Of Protein Targeting To Mitochondrion Ubiquitin Protein Ligase Binding Transferase Activity Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex ATP Binding Macromolecule Metabolic Process Nucleotide Binding Ubiquitin-protein Transferase Activator Activity Cytosol Protein Tag Activity Positive Regulation Of Establishment Of Protein Localization Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Activity Nucleoplasm
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