HERC4

Gene Name		HECT and RLD domain containing E3 ubiquitin protein ligase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity
	Biological Process	Spermatogenesis Cell Differentiation Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: HERC6 UBC UBE2D2 UBE2E3 UBE2J2
Entrez ID		26091
HPRD ID		13646
Ensembl ID		ENSG00000148634
Uniprot IDs		Q5GLZ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Protein Modification Process Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Proteolysis Toll-like Receptor 4 Signaling Pathway Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Protein Metabolic Process Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Hypoxia Viral Protein Processing Immune Response-regulating Signaling Pathway Notch Receptor Processing Protein K11-linked Ubiquitination Virion Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Immune System Process Positive Regulation Of Immune Response Protein K63-linked Ubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production
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