HERC4 and HERC6

Number of citations of the paper that reports this interaction (PMID 18535780)
6

Data Source:
HPRD (in vivo)

		HERC4	HERC6
Gene Name		HECT and RLD domain containing E3 ubiquitin protein ligase 4	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity	Ubiquitin-protein Transferase Activity Ligase Activity
	Biological Process	Spermatogenesis Cell Differentiation Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Hematopoietic Progenitor Cell Differentiation Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS			Metabolite levels ( 22916037)
Protein-Protein Interactions		5 interactors: HERC6 UBC UBE2D2 UBE2E3 UBE2J2	3 interactors: HERC3 HERC4 NME2
Entrez ID		26091	55008
HPRD ID		13646	13647
Ensembl ID		ENSG00000148634	ENSG00000138642
Uniprot IDs		Q5GLZ8	Q8IVU3
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Protein Modification Process Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Proteolysis Toll-like Receptor 4 Signaling Pathway Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Protein Metabolic Process Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Hypoxia Viral Protein Processing Immune Response-regulating Signaling Pathway Notch Receptor Processing Protein K11-linked Ubiquitination Virion Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Immune System Process Positive Regulation Of Immune Response Protein K63-linked Ubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Peptidyl-histidine Phosphorylation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Nucleobase-containing Small Molecule Interconversion Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Keratinocyte Differentiation Cellular Protein Modification Process Positive Regulation Of Epidermal Cell Differentiation Regulation Of Keratinocyte Differentiation GTP Biosynthetic Process UTP Biosynthetic Process Cellular Macromolecule Catabolic Process GTP Metabolic Process UTP Metabolic Process Positive Regulation Of Epidermis Development CTP Biosynthetic Process Nucleoside Diphosphate Phosphorylation Response To Testosterone Pyrimidine Ribonucleotide Biosynthetic Process Regulation Of Epidermal Cell Differentiation Cellular Response To Fatty Acid Pyrimidine Nucleoside Biosynthetic Process Response To Amine Cellular Protein Metabolic Process Negative Regulation Of Myeloid Leukocyte Differentiation Pyrimidine Nucleotide Biosynthetic Process Cellular Response To Drug Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Cellular Response To Glucose Stimulus Regulation Of Epidermis Development Pyrimidine Nucleoside Metabolic Process Response To Fatty Acid Hippocampus Development Positive Regulation Of Epithelial Cell Differentiation Pyrimidine Nucleotide Metabolic Process Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Nucleoside Triphosphate Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation Proteolysis Limbic System Development Protein Metabolic Process Regulation Of Myeloid Leukocyte Differentiation Response To CAMP
Tagcloud ?			al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Difference) ?			al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Intersection) ?