HERC4 and UBE2J2

Number of citations of the paper that reports this interaction (PMID 22496338)
5

Data Source:
BioGRID (pull down)

		HERC4	UBE2J2
Gene Name		HECT and RLD domain containing E3 ubiquitin protein ligase 4	ubiquitin-conjugating enzyme E2, J2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Spermatogenesis Cell Differentiation Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Response To Unfolded Protein ER-associated Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: HERC6 UBC UBE2D2 UBE2E3 UBE2J2	11 interactors: ATP13A2 HERC4 ITCH MGRN1 NEDD4L RNF10 TRIM25 UBC UBE2G2 WWP2 XIAP
Entrez ID		26091	118424
HPRD ID		13646	15600
Ensembl ID		ENSG00000148634	ENSG00000160087
Uniprot IDs		Q5GLZ8	A6NGS0 Q8N2K1
PDB IDs			2F4W
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Protein Modification Process Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Proteolysis Toll-like Receptor 4 Signaling Pathway Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Protein Metabolic Process Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Hypoxia Viral Protein Processing Immune Response-regulating Signaling Pathway Notch Receptor Processing Protein K11-linked Ubiquitination Virion Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Immune System Process Positive Regulation Of Immune Response Protein K63-linked Ubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Metabolic Process Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Negative Regulation Of Type I Interferon Production Viral Life Cycle Viral Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Type I Interferon Production Proteolysis Catabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Protein K63-linked Ubiquitination Negative Regulation Of Cytokine Production Positive Regulation Of Protein Catabolic Process Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Protein Monoubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Viral Entry Into Host Cell Regulation Of Innate Immune Response Entry Into Host Cell Protein Autoubiquitination Regulation Of Potassium Ion Transport Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Protein Linear Polyubiquitination Positive Regulation Of Caveolin-mediated Endocytosis Interaction With Host Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signaling Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?			abolished alter conjugating degradation disrupt ectopic enzyme er inactivated incubation localization mammalian pharmacological proteasomal proteasome regulating second state steady transfected truncated ubc ubcs ubiquitin ubiquitination unfolded unstable upr
Tagcloud (Difference) ?			abolished alter conjugating degradation disrupt ectopic enzyme er inactivated incubation localization mammalian pharmacological proteasomal proteasome regulating second state steady transfected truncated ubc ubcs ubiquitin ubiquitination unfolded unstable upr
Tagcloud (Intersection) ?