HERC4 and UBE2J2

Number of citations of the paper that reports this interaction (PubMedID 22496338)
65

Data Source:
BioGRID (pull down)

		HERC4	UBE2J2
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 4	ubiquitin conjugating enzyme E2 J2
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Protein Ubiquitination Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination ERAD Pathway Protein K6-linked Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 28892062)	Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 28067908)
Interacting Genes		7 interacting genes: HERC6 MAFA UBC UBE2D2 UBE2E3 UBE2J2 UBE2L3	22 interacting genes: AQP6 ATP13A2 ELOVL7 FBXO7 HECW1 HERC4 ITCH MARCHF6 MDM2 MGRN1 NEDD4L PRKN RBP1 RNF10 TMEM14B TRIM25 TRIM59 UBA1 UBC UBE2G2 WWP2 XIAP
Entrez ID		26091	118424
HPRD ID		13646	15600
Ensembl ID		ENSG00000148634	ENSG00000160087
Uniprot IDs		Q5GLZ8	A6NGS0 Q8N2K1
PDB IDs			2F4W
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Protein Modification Process Macromolecule Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Protein Metabolic Process Regulation Of Protein Targeting To Mitochondrion Ubiquitin Protein Ligase Binding Transferase Activity Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex ATP Binding Macromolecule Metabolic Process Nucleotide Binding Ubiquitin-protein Transferase Activator Activity Cytosol Protein Tag Activity Positive Regulation Of Establishment Of Protein Localization Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Activity Nucleoplasm	Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Macromolecule Catabolic Process Protein Modification Process Proteolysis Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Proteasomal Protein Catabolic Process Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Protein Metabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Positive Regulation Of Protein Linear Polyubiquitination Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Ligase Complex Ligase Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Autophagy Of Mitochondrion Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Manganese Ion Potassium Channel Inhibitor Activity Response To Oxidative Stress Protein K29-linked Ubiquitination Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Manganese Ion Positive Regulation Of Protein Catabolic Process Cellular Response To Oxidative Stress Negative Regulation Of Protein Localization Regulation Of Protein Transport Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Polyubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Exosomal Secretion
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