INKA1 and PAK5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		INKA1	PAK5
Description		inka box actin regulator 1	p21 (RAC1) activated kinase 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Membrane Synapse
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process		Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cellular Response To Starvation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS			Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		9 interacting genes: AIRIM APP DDX6 GPANK1 KIF9 PAK5 TRIM55 TRIM63 ZNF417	36 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MARK2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 SRSF11 TSGA10 TUBGCP4 UXT
Entrez ID		389119	57144
HPRD ID		14210	06423
Ensembl ID		ENSG00000185614	ENSG00000101349
Uniprot IDs		A0A499FIG1 Q96EL1	B0AZM9 Q9P286
PDB IDs		4XBR 4XBU	2F57 8C12
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Response To Interleukin-1 Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Concave Side Of Sperm Head Viral RNA Genome Packaging Microtubule Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Memory Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Regulation Of Generation Of Precursor Metabolites And Energy Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Skeletal Muscle Atrophy Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Learning Axon Choice Point Recognition Outer Dense Fiber Diapedesis	Cytoskeleton Organization Cytoskeleton Cytoplasm Wnt Signaling Pathway Microtubule-based Process Microtubule Nucleation Microtubule Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Organelle Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cell Projection Assembly Spindle Non-canonical Wnt Signaling Pathway Thioesterase Binding Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Centrosome Establishment Or Maintenance Of Cell Polarity Midbrain Dopaminergic Neuron Differentiation Cellular Component Assembly GTP-dependent Protein Binding Cytoplasmic Ribonucleoprotein Granule Actin Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Tau-protein Kinase Activity Establishment Of Cell Polarity Regulation Of Stress Fiber Assembly
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