ARG2 and CLIC6

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ARG2	CLIC6
Description		arginase 2	chloride intracellular channel 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Cytoplasm Plasma Membrane Membrane Monoatomic Ion Channel Complex Chloride Channel Complex Extracellular Exosome
	Molecular Function	Arginase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Manganese Ion Binding Metal Ion Binding	Chloride Channel Activity Oxidoreductase Activity D2 Dopamine Receptor Binding D3 Dopamine Receptor Binding D4 Dopamine Receptor Binding
	Biological Process	Urea Cycle Ureteric Bud Development Adaptive Immune Response Immune System Process Negative Regulation Of Type 2 Immune Response Arginine Metabolic Process Nitric Oxide Biosynthetic Process Striated Muscle Contraction Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Tumor Necrosis Factor Production Innate Immune Response Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 4 Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of Defense Response To Bacterium Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Cellular Senescence	Monoatomic Ion Transport Chloride Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Urea cycle Mitochondrial protein degradation
Drugs		Arginine Ornithine S-2-(Boronoethyl)-L-Cysteine
Diseases
GWAS			Asthma ( 31959851) Breast cancer ( 31757997) Epigenetic age acceleration in alcohol use disorder ( 31466081) Hippocampal volume ( 29274321) Psoriasis ( 25903422) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		3 interacting genes: ARG1 CLIC6 STK11	27 interacting genes: ACTB ALDH5A1 ARG2 ATRX CLIC4 DRD2 DRD3 DRD4 EEF1A1 FCGR1A GFPT2 HUWE1 LGI1 MYO1E NFE2L2 NISCH OXR1 PGK1 PKM PPRC1 TAF12 TUBGCP5 UBE4A ZNF18 ZNF224 ZNF234 ZNF439
Entrez ID		384	54102
HPRD ID		00143	10836
Ensembl ID		ENSG00000081181	ENSG00000159212
Uniprot IDs		P78540	Q96NY7
PDB IDs		1PQ3 4HZE 4I06 4IE2 4IE3 4IXU 4IXV 6Q37 6Q39 6SS2 6SS4 6SS6 8RFA 8RG6 8RGF 8RGU 8RIM 9FRV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neutrophil Mediated Killing Of Fungus Arginase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Negative Regulation Of Cell Growth Regulation Of Axonogenesis Dorsal/ventral Axon Guidance Axonogenesis Regulation Of Dendrite Development Spinal Cord Ventral Commissure Morphogenesis Intracellular Protein-containing Complex D2 Dopamine Receptor Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Killing Of Cells Of Another Organism Positive Regulation Of Vesicle Transport Along Microtubule Negative Regulation Of Growth L-arginine Catabolic Process Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Neutrophil Mediated Cytotoxicity Cell Projection Morphogenesis Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development Neuron Projection Morphogenesis LRR Domain Binding Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Response To Nematode Regulation Of Organelle Transport Along Microtubule Epithelial Cell Proliferation Involved In Prostate Gland Development Dendrite Extension Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Urea Metabolic Process Negative Regulation Of T Cell Cytokine Production Regulation Of Type II Interferon-mediated Signaling Pathway Nitrogen Cycle Metabolic Process Urea Cycle Regulation Of Response To Type II Interferon Negative Regulation Of Activated T Cell Proliferation Regulation Of Cell Growth Negative Regulation Of Collateral Sprouting Regulation Of Neurogenesis Cellular Response To UV-B Positive Thymic T Cell Selection Golgi Localization Anoikis Negative Regulation Of Type 2 Immune Response Positive T Cell Selection G1 To G0 Transition Regulation Of Neuron Projection Development	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Response To Histamine Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Arachidonate Secretion G Protein-coupled Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dopamine Binding Positive Regulation Of Neurotransmitter Uptake Long-chain Fatty Acid Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Adult Behavior Behavioral Response To Ethanol Regulation Of Dopamine Receptor Signaling Pathway Circadian Regulation Of Gene Expression Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Protein Secretion Prepulse Inhibition G Protein-coupled Receptor Internalization Locomotory Behavior Regulation Of Amine Transport Adult Locomotory Behavior Negative Regulation Of Cytosolic Calcium Ion Concentration Ubiquitin-ubiquitin Ligase Activity Response To Morphine Fatty Acid Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Response To Oxidative Stress Canonical Glycolysis Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Regulation Of Cellular Response To Hypoxia Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Secretory Granule Lumen Glucose Catabolic Process Regulation Of Transcription By RNA Polymerase II Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Transport Dopamine Metabolic Process Ficolin-1-rich Granule Lumen Regulation Of Response To Oxidative Stress Response To Amphetamine Regulation Of Cellular Response To Stress
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