ARG2

Name	arginase 2
Structure
Novel Interactors	1 novel interactors: DCC
Interactors	3 interactors: ARG1 CLIC6 STK11
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Arginase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Manganese Ion Binding Metal Ion Binding
	Biological Process	Urea Cycle Ureteric Bud Development Adaptive Immune Response Immune System Process Negative Regulation Of Type 2 Immune Response Arginine Metabolic Process Nitric Oxide Biosynthetic Process Striated Muscle Contraction Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Tumor Necrosis Factor Production Innate Immune Response Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 4 Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of Defense Response To Bacterium Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Cellular Senescence
Pathways	Urea cycle Mitochondrial protein degradation
Drugs	Arginine Ornithine S-2-(Boronoethyl)-L-Cysteine
GWAS	No GWAS studies recorded
Entrez ID	384
HPRD ID	00143
Ensembl ID	ENSG00000081181
Uniprot IDs	P78540
PDB IDs	1PQ3 4HZE 4I06 4IE2 4IE3 4IXU 4IXV 6Q37 6Q39 6SS2 6SS4 6SS6 8RFA 8RG6 8RGF 8RGU 8RIM 9FRV
GO Terms Enriched among Interactors ?	Positive Regulation Of Neutrophil Mediated Killing Of Fungus Arginase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Negative Regulation Of Cell Growth Regulation Of Axonogenesis Dorsal/ventral Axon Guidance Axonogenesis Regulation Of Dendrite Development Spinal Cord Ventral Commissure Morphogenesis Intracellular Protein-containing Complex D2 Dopamine Receptor Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Killing Of Cells Of Another Organism Positive Regulation Of Vesicle Transport Along Microtubule Negative Regulation Of Growth L-arginine Catabolic Process Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Neutrophil Mediated Cytotoxicity Cell Projection Morphogenesis Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development Neuron Projection Morphogenesis LRR Domain Binding Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Response To Nematode Regulation Of Organelle Transport Along Microtubule Epithelial Cell Proliferation Involved In Prostate Gland Development Dendrite Extension Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Urea Metabolic Process Negative Regulation Of T Cell Cytokine Production Regulation Of Type II Interferon-mediated Signaling Pathway Nitrogen Cycle Metabolic Process Urea Cycle Regulation Of Response To Type II Interferon Negative Regulation Of Activated T Cell Proliferation Regulation Of Cell Growth Negative Regulation Of Collateral Sprouting Regulation Of Neurogenesis Cellular Response To UV-B Positive Thymic T Cell Selection Golgi Localization Anoikis Negative Regulation Of Type 2 Immune Response Positive T Cell Selection G1 To G0 Transition Regulation Of Neuron Projection Development