ARG2 and ARG1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology), HPRD (in vivo)

		ARG2	ARG1
Name		arginase 2	arginase 1
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Azurophil Granule Lumen Specific Granule Lumen
	Molecular Function	Arginase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Manganese Ion Binding Metal Ion Binding	Arginase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Manganese Ion Binding Metal Ion Binding
	Biological Process	Urea Cycle Ureteric Bud Development Adaptive Immune Response Immune System Process Negative Regulation Of Type 2 Immune Response Arginine Metabolic Process Nitric Oxide Biosynthetic Process Striated Muscle Contraction Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Tumor Necrosis Factor Production Innate Immune Response Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 4 Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of Defense Response To Bacterium Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Cellular Senescence	Urea Cycle Adaptive Immune Response Immune System Process Arginine Metabolic Process L-arginine Catabolic Process Response To Nematode Regulation Of Cell Population Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Protozoan Innate Immune Response Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Neutrophil Mediated Killing Of Fungus Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Urea cycle Mitochondrial protein degradation	Neutrophil degranulation Urea cycle
Drugs		Arginine Ornithine S-2-(Boronoethyl)-L-Cysteine	Ornithine 2(S)-Amino-6-Boronohexanoic Acid nor-NOHA Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine Manganese
Diseases		None	Hyperargininemia
GWAS		No GWAS studies recorded	Apolipoprotein A1 levels ( 32203549 ) Blood protein levels ( 30072576 ) C-reactive protein levels ( 24763700 ) Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524 ) Chronic kidney disease ( 31152163 ) Creatinine levels ( 29403010 ) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708 ) Estimated glomerular filtration rate in diabetes ( 31451708 ) Glomerular filtration rate ( 29403010 ) HDL cholesterol levels ( 32203549 ) Obesity ( 21552555 ) Serum metabolite levels ( 33031748 ) Type 2 diabetes ( 30054458 )
Novel Interactors		1 novel interactors: DCC	None recorded
Interacting Genes		3 interacting genes: ARG1 CLIC6 STK11	6 interacting genes: ALDH4A1 ARG2 CDC42 FLOT1 NOS1 UCHL5
Entrez ID		384	383
HPRD ID		00143	01947
Ensembl ID		ENSG00000081181	ENSG00000118520
Uniprot IDs		P78540	A0A5F9ZH78 P05089
PDB IDs		1PQ3 4HZE 4I06 4IE2 4IE3 4IXU 4IXV 6Q37 6Q39 6SS2 6SS4 6SS6 8RFA 8RG6 8RGF 8RGU 8RIM 9FRV	1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1 6Q92 6Q9P 6QAF 6V7C 6V7D 6V7E 6V7F 7K4G 7K4H 7K4I 7K4J 7K4K 7KLK 7KLL 7KLM 7LEX 7LEY 7LEZ 7LF0 7LF1 7LF2 8AUP 8E5M 8E5N
GO Terms Enriched among Interactors		Positive Regulation Of Neutrophil Mediated Killing Of Fungus Arginase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Negative Regulation Of Cell Growth Regulation Of Axonogenesis Dorsal/ventral Axon Guidance Axonogenesis Regulation Of Dendrite Development Spinal Cord Ventral Commissure Morphogenesis Intracellular Protein-containing Complex D2 Dopamine Receptor Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Killing Of Cells Of Another Organism Positive Regulation Of Vesicle Transport Along Microtubule Negative Regulation Of Growth L-arginine Catabolic Process Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Neutrophil Mediated Cytotoxicity Cell Projection Morphogenesis Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development Neuron Projection Morphogenesis LRR Domain Binding Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Response To Nematode Regulation Of Organelle Transport Along Microtubule Epithelial Cell Proliferation Involved In Prostate Gland Development Dendrite Extension Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Urea Metabolic Process Negative Regulation Of T Cell Cytokine Production Regulation Of Type II Interferon-mediated Signaling Pathway Nitrogen Cycle Metabolic Process Urea Cycle Regulation Of Response To Type II Interferon Negative Regulation Of Activated T Cell Proliferation Regulation Of Cell Growth Negative Regulation Of Collateral Sprouting Regulation Of Neurogenesis Cellular Response To UV-B Positive Thymic T Cell Selection Golgi Localization Anoikis Negative Regulation Of Type 2 Immune Response Positive T Cell Selection G1 To G0 Transition Regulation Of Neuron Projection Development	Arginine Metabolic Process Nitric Oxide Biosynthetic Process Alpha-amino Acid Metabolic Process Regulation Of Neurotransmitter Uptake Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Amino Acid Metabolic Process Adherens Junction Organization Glutamine Family Amino Acid Metabolic Process Striated Muscle Contraction Negative Regulation Of Chemokine (C-C Motif) Ligand 4 Production Caveola L-amino Acid Catabolic Process Proteinogenic Amino Acid Catabolic Process L-glutamate Gamma-semialdehyde Dehydrogenase Activity Cell Periphery Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Arginase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Positive Regulation Of Signal Transduction Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Storage Vacuole Sarcolemma Nitric-oxide Synthase Activity Negative Regulation Of Serotonin Uptake Tetrahydrobiopterin Binding Amino Acid Catabolic Process Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Synaptic Signaling By Nitric Oxide Peptidyl-cysteine S-nitrosylase Activity L-proline Catabolic Process To L-glutamate Positive Regulation Of Synaptic Transmission, Dopaminergic Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Negative Regulation Of Defense Response To Bacterium Positive Regulation Of Endocytosis Apolipoprotein A-I Receptor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Neuropilin Signaling Pathway Regulation Of Serotonin Uptake L-amino Acid Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process L-proline Catabolic Process Cell-cell Junction Organization Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of The Force Of Heart Contraction