KIF11 and DCTN1

Number of citations of the paper that reports this interaction (PMID 9235942)
43

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro, in vivo)

		KIF11	DCTN1
Gene Name		kinesin family member 11	dynactin 1
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Cytoplasm Spindle Cytosol Kinesin Complex Microtubule Spindle Microtubule Membrane	Kinetochore Spindle Pole Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Retromer Complex Cell Leading Edge
	Molecular Function	Microtubule Motor Activity ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Protein Kinase Binding Protein Complex Binding	Motor Activity Protein Binding Dynein Binding
	Biological Process	Microtubule-based Movement Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Mitotic Centrosome Separation Blood Coagulation Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Mitotic Centrosome Separation Cell Division Mitotic Spindle Assembly	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Organelle Organization Mitotic Nuclear Division Nervous System Development Microtubule-based Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Melanosome Transport Retrograde Transport, Endosome To Golgi Cellular Protein Metabolic Process
Pathways		MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System	IRE1alpha activates chaperones MHC class II antigen presentation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Adaptive Immune System
Drugs		Adenosine-5\'-Diphosphate 3-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]Phenol Monastrol (4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE (5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE (2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide [(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONE (2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINE (2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE
Diseases
GWAS		Type 2 diabetes ( 21490949)
Protein-Protein Interactions		4 interactors: AURKA CDK1 DCTN1 PPARG	42 interactors: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 FBXL5 GRB2 GSK3B HAP1 KIAA0408 KIF11 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 VIM ZNF512B
Entrez ID		3832	1639
HPRD ID		01023	07206
Ensembl ID		ENSG00000138160	ENSG00000204843
Uniprot IDs		P52732	Q14203 Q6MZZ3
PDB IDs		1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2FME 2G1Q 2GM1 2IEH 2PG2 2Q2Y 2Q2Z 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 3CJO 3HQD 3K3B 3K5E 3KEN 3L9H 3ZCW 4A1Z 4A28 4A50 4A51 4A5Y 4AP0 4AQV 4AQW 4AS7 4B7B 4BBG 4BXN	1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Mitotic Nuclear Division Histone Phosphorylation Centrosome Cycle Regulation Of Cellular Protein Metabolic Process Organ Regeneration Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Glial Cell Differentiation Regulation Of Protein Metabolic Process Regulation Of Proteolysis Mitotic Cell Cycle Process Nervous System Development Centrosome Organization Regulation Of Gliogenesis Microtubule Organizing Center Organization Mitotic Cell Cycle Microtubule-based Process Peptidyl-serine Phosphorylation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of DNA Replication Response To Metformin Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Response To Diuretic Negative Regulation Of Spindle Checkpoint Pronuclear Fusion Regulation Of Cell Development Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Cholesterol Transporter Activity Spindle Assembly Involved In Female Meiosis I Cellular Response To Vitamin E Cell Cycle Process Positive Regulation Of Metabolic Process Spindle Assembly Involved In Meiosis Cellular Response To Insulin Stimulus Positive Regulation Of Protein Catabolic Process Spindle Stabilization Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cell Cycle Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Cell Cycle	Cell Cycle Microtubule-based Process Organelle Organization Cell Cycle Process Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Microtubule-based Movement Microtubule-based Transport Regulation Of Cell Cycle Cytoskeleton-dependent Intracellular Transport Minus-end-directed Organelle Transport Along Microtubule Movement Of Cell Or Subcellular Component Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Antigen Processing And Presentation Organelle Transport Along Microtubule Immune System Process Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Antigen Processing And Presentation Of Peptide Antigen Intracellular Transport Execution Phase Of Apoptosis Cellular Protein Localization Cytoskeleton Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Localization Cellular Localization Microtubule Anchoring At Microtubule Organizing Center Neurotrophin TRK Receptor Signaling Pathway Regulation Of Metabolic Process Neurotrophin Signaling Pathway Regulation Of Organelle Organization Establishment Of Localization In Cell Protein Localization To Cytoskeleton Cell Division Generation Of Neurons Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Cilium Assembly Organelle Assembly Neurogenesis Mitotic Nuclear Division Anatomical Structure Development Regulation Of Cell Projection Organization Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Process
Tagcloud ?		affymetrix annotations apdf aurka bicarbonate blpdf bpdf buffered ccnb1 ccne2 cdk1 containingpdf cpdf diamond diluted genechip icodextrin insufficiently ipdf kif14 lpdf mesothelial omentum pdf pmc repressors smc4 u133plus2 uremic	als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp
Tagcloud (Difference) ?		affymetrix annotations apdf aurka bicarbonate blpdf bpdf buffered ccnb1 ccne2 cdk1 containingpdf cpdf diamond diluted genechip icodextrin insufficiently ipdf kif14 lpdf mesothelial omentum pdf pmc repressors smc4 u133plus2 uremic	als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp
Tagcloud (Intersection) ?