KIF11 and RNF40

Number of citations of the paper that reports this interaction (PubMedID 27557628)
44

Data Source:
BioGRID (enzymatic study)

		KIF11	RNF40
Description		kinesin family member 11	ring finger protein 40
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Spindle Microtubule Membrane Protein-containing Complex Ciliary Basal Body Mitotic Spindle	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane HULC Complex
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Protein Kinase Binding	MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitotic Cell Cycle Microtubule-based Movement Spindle Organization Mitotic Spindle Organization Mitotic Centrosome Separation Regulation Of Mitotic Centrosome Separation Spindle Assembly Spindle Elongation Cell Division Mitotic Spindle Assembly Mitotic Nuclear Division	Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins	E3 ubiquitin ligases ubiquitinate target proteins
Drugs		3-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]Phenol Monastrol Filanesib (4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE (5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE MK-0731 [(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONE (2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINE (2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE
Diseases
GWAS		Asthma ( 30929738 31619474 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood glucose levels ( 31928498) Inflammatory bowel disease ( 28067908) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29785010 30054594) Pancreatic beta-cell glucose sensitivity ( 32944759) Triglyceride levels ( 31928498) Type 2 diabetes ( 21490949 31118516)	Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		12 interacting genes: AURKA CDK1 CEBPA DCTN1 ERCC1 ERCC4 PPARG RNF20 RNF40 SRPK2 SUMO2 UHRF1	27 interacting genes: AMOTL2 ATM CCDC146 CDC73 DUSP29 EEF1D H2AC4 H2BC3 ITSN1 KIF11 MEOX2 MSL1 MTNR1B NCBP1 NINL PKNOX1 RB1 RPA1 RPA2 TRIM51 UBE2A UBE2B UBE2D2 UBE2I UBE2L6 ZCCHC12 ZNF451
Entrez ID		3832	9810
HPRD ID		01023	07411
Ensembl ID		ENSG00000138160	ENSG00000103549
Uniprot IDs		P52732	A8K6K1 O75150
PDB IDs		1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2FME 2G1Q 2GM1 2IEH 2PG2 2Q2Y 2Q2Z 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 3CJO 3HQD 3K3B 3K5E 3KEN 3L9H 3WPN 3ZCW 4A1Z 4A28 4A50 4A51 4A5Y 4AP0 4AQV 4AQW 4AS7 4B7B 4BBG 4BXN 4CK5 4CK6 4CK7 4ZCA 4ZHI 5JV3 5ZO7 5ZO8 5ZO9 6G6Y 6G6Z 6HKX 6HKY 6TA3 6TA4 6TIW 6TLE 6TRL 6Y1I 8YHH	8GUI 8GUJ 8IEJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Negative Regulation Of Protection From Non-homologous End Joining At Telomere Positive Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Spindle ERCC4-ERCC1 Complex Negative Regulation Of Telomere Maintenance In Response To DNA Damage 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Nucleoplasm HULC Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleotide-excision Repair Complex Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Organelle Organization Negative Regulation Of Telomere Capping Regulation Of RNA Metabolic Process Chromatin Organization Spindle Regulation Of Mitotic Cell Cycle Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding Regulation Of Gene Expression Cilium Disassembly Regulation Of Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process STAT Family Protein Binding Regulation Of Macromolecule Biosynthetic Process UV Protection Macromolecule Metabolic Process Telomere Maintenance Via Recombination Regulation Of Telomere Capping Cellular Response To Stress Cilium Organization Nuclear Membrane Disassembly Nucleus Ubiquitin Protein Ligase Binding Membrane Disassembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Ubiquitin Conjugating Enzyme Activity Protein Localization To Chromosome PML Body Ubiquitin-like Protein Transferase Activity Chromosome, Telomeric Region Positive Regulation Of MRNA 3'-end Processing HULC Complex Chromatin Organization Nucleus Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Protein Modification By Small Protein Conjugation Protein Polyubiquitination Telomere Localization Regulation Of MRNA 3'-end Processing G-rich Strand Telomeric DNA Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition DNA Replication Factor A Complex Chromosome Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Post-translational Protein Modification Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Negative Regulation Of Cell Cycle Phase Transition Site Of Double-strand Break Chromatin Remodeling Telomere Maintenance Proteolysis Involved In Protein Catabolic Process Histone MRNA Metabolic Process Response To Radiation Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Localization To Site Of Double-strand Break Sperm Axoneme Assembly Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Mismatch Repair Telomere Organization DNA Repair MRNA 3'-end Processing Double-strand Break Repair Via Homologous Recombination Ubiquitin Protein Ligase Binding Recombinational Repair Regulation Of DNA Recombination Positive Regulation Of RNA Binding
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