ARG1 and NOS1

Number of citations of the paper that reports this interaction (PMID 11849441)
3

Data Source:
HPRD (in vivo)

		ARG1	NOS1
Gene Name		arginase 1	nitric oxide synthase 1 (neuronal)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Neuron Projection Neuronal Cell Body Extracellular Vesicular Exosome	Photoreceptor Inner Segment Cytoplasm Mitochondrion Cytosol Cytoskeleton Sarcoplasmic Reticulum Sarcolemma Dendritic Spine Protein Complex Membrane Raft Synapse Perinuclear Region Of Cytoplasm Ryanodine Receptor Complex
	Molecular Function	Arginase Activity Manganese Ion Binding	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Ion Channel Binding Cadmium Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding
	Biological Process	Urea Cycle Liver Development Positive Regulation Of Endothelial Cell Proliferation Arginine Catabolic Process Response To Herbicide Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Regulation Of L-arginine Import Response To Amine Lung Development Collagen Biosynthetic Process Response To Vitamin A Response To Vitamin E Cellular Nitrogen Compound Metabolic Process Response To Drug Response To Amino Acid Small Molecule Metabolic Process Response To Cadmium Ion Response To Axon Injury Response To Methylmercury Mammary Gland Involution Maternal Process Involved In Female Pregnancy Protein Homotrimerization Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus	Response To Hypoxia Regulation Of Sodium Ion Transport Arginine Catabolic Process Nitric Oxide Biosynthetic Process Striated Muscle Contraction Nitric Oxide Mediated Signal Transduction Myoblast Fusion Blood Coagulation Response To Heat Negative Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Multicellular Organismal Response To Stress Positive Regulation Of Histone Acetylation Neurotransmitter Biosynthetic Process Exogenous Drug Catabolic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Hydrolase Activity Negative Regulation Of Serotonin Uptake Interaction With Host Negative Regulation Of Calcium Ion Transport Oxidation-reduction Process Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Growth Factor Stimulus Phagosome Maturation Positive Regulation Of The Force Of Heart Contraction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Generation Of L-type Calcium Current
Pathways		Urea cycle Metabolism of amino acids and derivatives	Platelet homeostasis Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Nitric oxide stimulates guanylate cyclase
Drugs		L-Ornithine 2(S)-Amino-6-Boronohexanoic Acid Nor-N-Omega-Hydroxy-L-Arginine Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N-Omega-Hydroxy-L-Arginine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine	L-Citrulline L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide Formic Acid 3-Bromo-7-Nitroindazole N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N\'-Nitroguanidine N-(3-(Aminomethyl)Benzyl)Acetamidine L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide N-Isopropyl-N\'-Hydroxyguanidine N-Omega-Propyl-L-Arginine (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin N-Butyl-N\'-Hydroxyguanidine Alpha-D-Mannose S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea Heme N-Omega-Hydroxy-L-Arginine Flavin-Adenine Dinucleotide Riboflavin Monophosphate N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine 2\'-Monophosphoadenosine 5\'-Diphosphoribose S-Ethyl-N-Phenyl-Isothiourea N5-(1-Imino-3-Butenyl)-L-Ornithine 5-N-Allyl-Arginine Nitroarginine N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N\'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N\'-(3-chlorobenzyl)ethane-1,2-diamine
Diseases
GWAS		Obesity ( 21552555)
Protein-Protein Interactions		5 interactors: ALDH4A1 ARG2 FLOT1 NOS1 UCHL5	33 interactors: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM PRKACA PRKCA PTPN6 PTPRN RASD1 SNTA1 STUB1 SUMO1 SYN1 VAC14 ZDHHC23
Entrez ID		383	4842
HPRD ID		01947	01226
Ensembl ID		ENSG00000118520	ENSG00000089250
Uniprot IDs		P05089	A0PJJ7 B3VK56 B4DG68 P29475
PDB IDs		1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1
Enriched GO Terms of Interacting Partners?		Alpha-amino Acid Metabolic Process Cellular Amino Acid Metabolic Process Nitric Oxide Biosynthetic Process Arginine Metabolic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Striated Muscle Contraction Dicarboxylic Acid Metabolic Process Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Reactive Oxygen Species Metabolic Process Cellular Amino Acid Catabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Serotonin Uptake Proline Catabolic Process To Glutamate Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Nitrogen Compound Metabolic Process Carboxylic Acid Catabolic Process Regulation Of Generation Of L-type Calcium Current 4-hydroxyproline Catabolic Process Positive Regulation Of The Force Of Heart Contraction Muscle Contraction Peptidyl-cysteine S-nitrosylation Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Regulation Of Adrenergic Receptor Signaling Pathway Muscle System Process Methotrexate Transport Glutamate Biosynthetic Process Arginine Catabolic Process Folic Acid Transport Negative Regulation Of Calcium Ion Transport Into Cytosol Proline Catabolic Process Positive Regulation Of Guanylate Cyclase Activity Folic Acid Metabolic Process Urea Cycle Negative Regulation Of Hydrolase Activity Urea Metabolic Process Regulation Of Neurotransmitter Uptake Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Sodium Ion Transmembrane Transport Neurotransmitter Biosynthetic Process Nitric Oxide Mediated Signal Transduction Positive Regulation Of CGMP Biosynthetic Process Catabolic Process Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway	Regulation Of Heart Contraction Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction Cell-cell Signaling Regulation Of Catalytic Activity Regulation Of Ion Transport Regulation Of Cardiac Muscle Hypertrophy Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Cardiac Muscle Contraction Regulation Of Signaling Regulation Of Striated Muscle Contraction Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Regulation Of Phosphorus Metabolic Process Signaling Cell Communication Regulation Of Cellular Localization Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Chemical Homeostasis Regulation Of Metabolic Process Negative Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Signal Transduction Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metal Ion Homeostasis Synaptic Transmission Regulation Of Oxidoreductase Activity Regulation Of Phosphorylation Activation Of Adenylate Cyclase Activity Cellular Response To Stimulus Cellular Cation Homeostasis Homeostatic Process Cellular Calcium Ion Homeostasis Vasoconstriction Cellular Ion Homeostasis Regulation Of Blood Pressure Calcium Ion Homeostasis Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Signal Transduction Cytosolic Calcium Ion Homeostasis Cellular Localization Metal Ion Homeostasis Blood Circulation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport
Tagcloud ?		angle arabidopsis auxin caenorhabditis cloning coil coiled coils cytoskeleton downward elegans gravitropic gravitropism gravity gus hypocotyl organs ortholog participates phototropism phytohormones positional root roots shoots starch thaliana ubiquitous upward	adenine afterload arrhythmias arrhythmogenic camkii cardiomyocyte cardiomyocytes cardiomyopathy contract contractility contraction counter diastole dinucleotide heartbeat hypertrophic imposes mechanochemotransduction mechanotransduction nicotinamide nnos nos3 nox2 ryanodine ryr sarcoplasmic sparks super transducing
Tagcloud (Difference) ?		angle arabidopsis auxin caenorhabditis cloning coil coiled coils cytoskeleton downward elegans gravitropic gravitropism gravity gus hypocotyl organs ortholog participates phototropism phytohormones positional root roots shoots starch thaliana ubiquitous upward	adenine afterload arrhythmias arrhythmogenic camkii cardiomyocyte cardiomyocytes cardiomyopathy contract contractility contraction counter diastole dinucleotide heartbeat hypertrophic imposes mechanochemotransduction mechanotransduction nicotinamide nnos nos3 nox2 ryanodine ryr sarcoplasmic sparks super transducing
Tagcloud (Intersection) ?