ARG1 and ARG2

Number of citations of the paper that reports this interaction (PMID 11849441)
3

Data Source:
HPRD (in vivo)

		ARG1	ARG2
Gene Name		arginase 1	arginase 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Neuron Projection Neuronal Cell Body Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Matrix
	Molecular Function	Arginase Activity Manganese Ion Binding	Arginase Activity Metal Ion Binding
	Biological Process	Urea Cycle Liver Development Positive Regulation Of Endothelial Cell Proliferation Arginine Catabolic Process Response To Herbicide Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Regulation Of L-arginine Import Response To Amine Lung Development Collagen Biosynthetic Process Response To Vitamin A Response To Vitamin E Cellular Nitrogen Compound Metabolic Process Response To Drug Response To Amino Acid Small Molecule Metabolic Process Response To Cadmium Ion Response To Axon Injury Response To Methylmercury Mammary Gland Involution Maternal Process Involved In Female Pregnancy Protein Homotrimerization Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus	Urea Cycle Ureteric Bud Development Arginine Metabolic Process Nitric Oxide Biosynthetic Process Striated Muscle Contraction Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process
Pathways		Urea cycle Metabolism of amino acids and derivatives	Urea cycle Metabolism of amino acids and derivatives
Drugs		L-Ornithine 2(S)-Amino-6-Boronohexanoic Acid Nor-N-Omega-Hydroxy-L-Arginine Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N-Omega-Hydroxy-L-Arginine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine	L-Arginine L-Ornithine S-2-(Boronoethyl)-L-Cysteine
Diseases
GWAS		Obesity ( 21552555)
Protein-Protein Interactions		5 interactors: ALDH4A1 ARG2 FLOT1 NOS1 UCHL5	1 interactors: ARG1
Entrez ID		383	384
HPRD ID		01947	00143
Ensembl ID		ENSG00000118520	ENSG00000081181
Uniprot IDs		P05089	P78540
PDB IDs		1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1	1PQ3 4HZE 4I06 4IE2 4IE3
Enriched GO Terms of Interacting Partners?		Alpha-amino Acid Metabolic Process Cellular Amino Acid Metabolic Process Nitric Oxide Biosynthetic Process Arginine Metabolic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Striated Muscle Contraction Dicarboxylic Acid Metabolic Process Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Reactive Oxygen Species Metabolic Process Cellular Amino Acid Catabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Serotonin Uptake Proline Catabolic Process To Glutamate Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Nitrogen Compound Metabolic Process Carboxylic Acid Catabolic Process Regulation Of Generation Of L-type Calcium Current 4-hydroxyproline Catabolic Process Positive Regulation Of The Force Of Heart Contraction Muscle Contraction Peptidyl-cysteine S-nitrosylation Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Regulation Of Adrenergic Receptor Signaling Pathway Muscle System Process Methotrexate Transport Glutamate Biosynthetic Process Arginine Catabolic Process Folic Acid Transport Negative Regulation Of Calcium Ion Transport Into Cytosol Proline Catabolic Process Positive Regulation Of Guanylate Cyclase Activity Folic Acid Metabolic Process Urea Cycle Negative Regulation Of Hydrolase Activity Urea Metabolic Process Regulation Of Neurotransmitter Uptake Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Sodium Ion Transmembrane Transport Neurotransmitter Biosynthetic Process Nitric Oxide Mediated Signal Transduction Positive Regulation Of CGMP Biosynthetic Process Catabolic Process Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway	Regulation Of L-arginine Import Mammary Gland Involution Response To Selenium Ion Arginine Catabolic Process Response To Herbicide Response To Methylmercury Urea Cycle Collagen Biosynthetic Process Urea Metabolic Process Response To Manganese Ion Protein Homotrimerization Response To Vitamin E Arginine Metabolic Process Response To Vitamin A Cellular Response To Dexamethasone Stimulus Protein Trimerization Response To Dexamethasone Cellular Response To Glucagon Stimulus Cellular Response To Interleukin-4 Response To Zinc Ion Response To Interleukin-4 Response To Amine Cellular Response To Glucocorticoid Stimulus Response To Glucagon Cellular Response To Corticosteroid Stimulus Response To Cadmium Ion Cellular Response To Hydrogen Peroxide Positive Regulation Of Endothelial Cell Proliferation Response To Axon Injury Collagen Metabolic Process Maternal Process Involved In Female Pregnancy Multicellular Organismal Macromolecule Metabolic Process Mammary Gland Morphogenesis Regulation Of Endothelial Cell Proliferation Multicellular Organismal Metabolic Process Cellular Response To Reactive Oxygen Species Response To Vitamin Response To Amino Acid Tissue Remodeling Cellular Amino Acid Catabolic Process Response To Hydrogen Peroxide Regulation Of Anion Transport Positive Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Liver Development Response To Glucocorticoid Gland Morphogenesis Cellular Response To Molecule Of Bacterial Origin Response To Corticosteroid Mammary Gland Development
Tagcloud ?		angle arabidopsis auxin caenorhabditis cloning coil coiled coils cytoskeleton downward elegans gravitropic gravitropism gravity gus hypocotyl organs ortholog participates phototropism phytohormones positional root roots shoots starch thaliana ubiquitous upward	acting acts agonist analogue antagonist basal biochemical camp confirming consistent d dermorphin fentanyl inositol messengers mu mu1 mu2 opioid phe reversed sarcosine4 sh subtype sy5y trisphosphate tyr unknown yet
Tagcloud (Difference) ?		angle arabidopsis auxin caenorhabditis cloning coil coiled coils cytoskeleton downward elegans gravitropic gravitropism gravity gus hypocotyl organs ortholog participates phototropism phytohormones positional root roots shoots starch thaliana ubiquitous upward	acting acts agonist analogue antagonist basal biochemical camp confirming consistent d dermorphin fentanyl inositol messengers mu mu1 mu2 opioid phe reversed sarcosine4 sh subtype sy5y trisphosphate tyr unknown yet
Tagcloud (Intersection) ?