ARG1 and FLOT1

Number of citations of the paper that reports this interaction (PMID 17113085)
3

Data Source:
HPRD (in vitro)

		ARG1	FLOT1
Gene Name		arginase 1	flotillin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Neuron Projection Neuronal Cell Body Extracellular Vesicular Exosome	Lysosomal Membrane Endosome Microtubule Organizing Center Caveola Focal Adhesion COP9 Signalosome Membrane Integral Component Of Membrane Flotillin Complex Centriolar Satellite Sarcolemma Melanosome Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Arginase Activity Manganese Ion Binding	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Urea Cycle Liver Development Positive Regulation Of Endothelial Cell Proliferation Arginine Catabolic Process Response To Herbicide Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Regulation Of L-arginine Import Response To Amine Lung Development Collagen Biosynthetic Process Response To Vitamin A Response To Vitamin E Cellular Nitrogen Compound Metabolic Process Response To Drug Response To Amino Acid Small Molecule Metabolic Process Response To Cadmium Ion Response To Axon Injury Response To Methylmercury Mammary Gland Involution Maternal Process Involved In Female Pregnancy Protein Homotrimerization Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus	Axonogenesis Extracellular Matrix Disassembly Regulation Of Rho Protein Signal Transduction Establishment Of Protein Localization To Plasma Membrane
Pathways		Urea cycle Metabolism of amino acids and derivatives
Drugs		L-Ornithine 2(S)-Amino-6-Boronohexanoic Acid Nor-N-Omega-Hydroxy-L-Arginine Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N-Omega-Hydroxy-L-Arginine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine
Diseases
GWAS		Obesity ( 21552555)	Ulcerative colitis ( 20848476)
Protein-Protein Interactions		5 interactors: ALDH4A1 ARG2 FLOT1 NOS1 UCHL5	16 interactors: APP ARG1 AURKB CAPN10 CBL FLOT2 FYN GOLM1 INCENP NGB PSMD4 SHBG SORBS1 SORBS2 SORBS3 SRPK1
Entrez ID		383	10211
HPRD ID		01947	06105
Ensembl ID		ENSG00000118520	ENSG00000137312
Uniprot IDs		P05089	B4DVY7 O75955 Q5ST80
PDB IDs		1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1
Enriched GO Terms of Interacting Partners?		Alpha-amino Acid Metabolic Process Cellular Amino Acid Metabolic Process Nitric Oxide Biosynthetic Process Arginine Metabolic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Striated Muscle Contraction Dicarboxylic Acid Metabolic Process Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Reactive Oxygen Species Metabolic Process Cellular Amino Acid Catabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Serotonin Uptake Proline Catabolic Process To Glutamate Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Nitrogen Compound Metabolic Process Carboxylic Acid Catabolic Process Regulation Of Generation Of L-type Calcium Current 4-hydroxyproline Catabolic Process Positive Regulation Of The Force Of Heart Contraction Muscle Contraction Peptidyl-cysteine S-nitrosylation Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Regulation Of Adrenergic Receptor Signaling Pathway Muscle System Process Methotrexate Transport Glutamate Biosynthetic Process Arginine Catabolic Process Folic Acid Transport Negative Regulation Of Calcium Ion Transport Into Cytosol Proline Catabolic Process Positive Regulation Of Guanylate Cyclase Activity Folic Acid Metabolic Process Urea Cycle Negative Regulation Of Hydrolase Activity Urea Metabolic Process Regulation Of Neurotransmitter Uptake Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Sodium Ion Transmembrane Transport Neurotransmitter Biosynthetic Process Nitric Oxide Mediated Signal Transduction Positive Regulation Of CGMP Biosynthetic Process Catabolic Process Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway	Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cell Adhesion Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signaling Positive Regulation Of Cell Cycle Process Organelle Organization Positive Regulation Of Glucose Import Chromosome Segregation Cellular Response To Hormone Stimulus Positive Regulation Of Glucose Transport Actin Cytoskeleton Organization Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament-based Process Regulation Of L-arginine Import Primary Spermatocyte Growth Positive Regulation Of Cell Cycle Regulation Of Glucose Import Actin Filament Organization Positive Regulation Of Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of ERBB Signaling Pathway Synaptic Growth At Neuromuscular Junction Type B Pancreatic Cell Apoptotic Process Developmental Cell Growth Response To Organonitrogen Compound Regulation Of Apoptotic Process Feeding Behavior Regulation Of Glucose Transport Histone H3-S28 Phosphorylation Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Metabolic Process Cytokinesis Negative Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Spindle Stabilization Response To Hormone Nucleus Organization Apoptotic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cell Death Dendrite Development
Tagcloud ?		angle arabidopsis auxin caenorhabditis cloning coil coiled coils cytoskeleton downward elegans gravitropic gravitropism gravity gus hypocotyl organs ortholog participates phototropism phytohormones positional root roots shoots starch thaliana ubiquitous upward	anchorage archived caveolin chicken chorioallantoic constitutive downregulation electrophoretic escc esccs esophageal essc flot2 hyperactivation intermediaries inverse inversely k63 luciferase mir polyubiquitination raft rafts rip1 suppressive traf2 transwell upregulating vital
Tagcloud (Difference) ?		angle arabidopsis auxin caenorhabditis cloning coil coiled coils cytoskeleton downward elegans gravitropic gravitropism gravity gus hypocotyl organs ortholog participates phototropism phytohormones positional root roots shoots starch thaliana ubiquitous upward	anchorage archived caveolin chicken chorioallantoic constitutive downregulation electrophoretic escc esccs esophageal essc flot2 hyperactivation intermediaries inverse inversely k63 luciferase mir polyubiquitination raft rafts rip1 suppressive traf2 transwell upregulating vital
Tagcloud (Intersection) ?