ACAT1 and AGXT

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ACAT1	AGXT
Gene Name		acetyl-CoA acetyltransferase 1	alanine-glyoxylate aminotransferase
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Extracellular Vesicular Exosome	Mitochondrial Matrix Peroxisome Peroxisomal Matrix
	Molecular Function	Acetyl-CoA C-acetyltransferase Activity Enzyme Binding Protein Homodimerization Activity Metal Ion Binding Coenzyme Binding	Serine-pyruvate Transaminase Activity Receptor Binding Protein Binding Alanine-glyoxylate Transaminase Activity Transaminase Activity Amino Acid Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity
	Biological Process	Liver Development Brain Development Branched-chain Amino Acid Catabolic Process Response To Hormone Response To Organic Cyclic Compound Cellular Nitrogen Compound Metabolic Process Response To Starvation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cellular Ketone Body Metabolic Process Ketone Body Biosynthetic Process Ketone Body Catabolic Process Protein Homooligomerization Adipose Tissue Development Metanephric Proximal Convoluted Tubule Development	Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-cysteine Catabolic Process Cellular Nitrogen Compound Metabolic Process L-alanine Catabolic Process Pyruvate Biosynthetic Process Small Molecule Metabolic Process Glyoxylate Metabolic Process Oxalic Acid Secretion Response To Glucocorticoid Response To CAMP
Pathways		Ketone body metabolism Fatty acid, triacylglycerol, and ketone body metabolism Synthesis of Ketone Bodies Metabolism of lipids and lipoproteins Branched-chain amino acid catabolism Utilization of Ketone Bodies Metabolism of amino acids and derivatives	Glyoxylate metabolism Metabolism of amino acids and derivatives
Drugs		Sulfasalazine	Pyridoxal Phosphate L-Serine Glycine L-Alanine (Aminooxy)Acetic Acid N\'-Pyridoxyl-Lysine-5\'-Monophosphate 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
Diseases
GWAS
Protein-Protein Interactions		2 interactors: AGXT PEX7	3 interactors: ACAT1 PEX5 SNCAIP
Entrez ID		38	189
HPRD ID		01946	05048
Ensembl ID		ENSG00000075239	ENSG00000172482
Uniprot IDs		P24752	P21549
PDB IDs		2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY	1H0C 1J04 3R9A 4I8A
Enriched GO Terms of Interacting Partners?		Carboxylic Acid Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate Oxalic Acid Secretion L-cysteine Catabolic Process Glyoxylate Catabolic Process L-alanine Metabolic Process L-alanine Catabolic Process Oxalate Transport Pyruvate Biosynthetic Process Ether Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Glyoxylate Metabolic Process Cysteine Metabolic Process Ether Lipid Metabolic Process Protein Import Into Peroxisome Matrix Glycine Biosynthetic Process Serine Family Amino Acid Catabolic Process Sulfur Amino Acid Catabolic Process Aldehyde Catabolic Process Glycerol Ether Metabolic Process Carboxylic Acid Metabolic Process Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Organic Acid Metabolic Process Glycine Metabolic Process Endochondral Ossification Sulfur Amino Acid Metabolic Process Fatty Acid Beta-oxidation Peroxisome Organization Intracellular Protein Transmembrane Transport Serine Family Amino Acid Metabolic Process Acid Secretion Protein Transmembrane Transport Fatty Acid Oxidation Lipid Oxidation Catabolic Process Fatty Acid Catabolic Process Cellular Aldehyde Metabolic Process Dicarboxylic Acid Transport Endochondral Bone Morphogenesis Small Molecule Metabolic Process Cellular Amino Acid Catabolic Process Bone Morphogenesis Response To CAMP Pyruvate Metabolic Process Cellular Amino Acid Biosynthetic Process Cellular Lipid Catabolic Process Response To Organophosphorus Protein Import Response To Glucocorticoid	Cholesterol Storage Lipid Modification Carboxylic Acid Catabolic Process Metanephric Proximal Convoluted Tubule Development Negative Regulation Of Protein Homotetramerization Protein Import Into Peroxisome Matrix, Translocation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Macrophage Derived Foam Cell Differentiation Metanephric Proximal Tubule Development Cholesterol Esterification Protein Import Into Peroxisome Matrix, Docking Ketone Body Catabolic Process Proximal Tubule Development Negative Regulation Of Protein Homooligomerization Protein Import Into Peroxisome Membrane Protein To Membrane Docking Protein Oligomerization Regulation Of Amyloid Precursor Protein Biosynthetic Process Very-low-density Lipoprotein Particle Assembly Peroxisomal Membrane Transport Negative Regulation Of Protein Oligomerization Ketone Body Biosynthetic Process Cellular Ketone Body Metabolic Process Protein Import Into Peroxisome Matrix Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Glycoprotein Metabolic Process Metanephric Nephron Tubule Development Protein-lipid Complex Assembly Regulation Of Inclusion Body Assembly Branched-chain Amino Acid Catabolic Process Brain Development Establishment Of Protein Localization To Peroxisome Protein Targeting To Peroxisome Head Development Very Long-chain Fatty Acid Metabolic Process Cerebral Cortex Neuron Differentiation Dopamine Metabolic Process Cholesterol Efflux Regulation Of Protein Oligomerization Regulation Of Glycoprotein Biosynthetic Process Metanephric Epithelium Development Adipose Tissue Development Cellular Lipid Metabolic Process Central Nervous System Development Lipid Storage Endoplasmic Reticulum Organization Catecholamine Metabolic Process Fatty Acid Beta-oxidation Peroxisome Organization Carboxylic Acid Metabolic Process
Tagcloud ?		abeta1 acyl acyltransferase amyloidopathy autophagosome blockage blocking buildup coa converting coordinated degrade disrupt eb esters implicate k604 knock ko lysosomal microglia misfolded oligomeric phagocytic pharmacologically proteolysis proteolytic resident stimulates	aim2 alox12 built cpg discriminate discriminated e85 epigenome false il10 jak3 lcn2 leukocyte manifested methqtl obtainable p1075 p180 p220 p348 p624 p817 p86 pac penalized resectable smoker statistic zap70
Tagcloud (Difference) ?		abeta1 acyl acyltransferase amyloidopathy autophagosome blockage blocking buildup coa converting coordinated degrade disrupt eb esters implicate k604 knock ko lysosomal microglia misfolded oligomeric phagocytic pharmacologically proteolysis proteolytic resident stimulates	aim2 alox12 built cpg discriminate discriminated e85 epigenome false il10 jak3 lcn2 leukocyte manifested methqtl obtainable p1075 p180 p220 p348 p624 p817 p86 pac penalized resectable smoker statistic zap70
Tagcloud (Intersection) ?