ACAT1 and CXCR4

Data Source: HiPPIP (Novel)

		ACAT1	CXCR4
Name		acetyl-CoA acetyltransferase 1	C-X-C motif chemokine receptor 4
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Extracellular Exosome	Cytoplasm Lysosome Endosome Early Endosome Late Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Acetyl-CoA C-acetyltransferase Activity C-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Enzyme Binding Potassium Ion Binding Cholesterol O-acyltransferase Activity Identical Protein Binding Metal Ion Binding Coenzyme A Binding	Virus Receptor Activity Actin Binding G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Cytokine Binding C-C Chemokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding C-X-C Motif Chemokine 12 Receptor Activity Ubiquitin Binding
	Biological Process	Liver Development Acetyl-CoA Biosynthetic Process L-isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Response To Hormone Coenzyme A Metabolic Process Coenzyme A Biosynthetic Process Response To Starvation Acetyl-CoA Catabolic Process Ketone Body Catabolic Process Adipose Tissue Development Metanephric Proximal Convoluted Tubule Development Ketone Body Metabolic Process Propionyl-CoA Biosynthetic Process	Response To Hypoxia Dendritic Cell Chemotaxis Apoptotic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Brain Development Response To Virus Cell Migration Calcium-mediated Signaling Neurogenesis Regulation Of Cell Adhesion Regulation Of Cell Migration Positive Regulation Of Cell Migration CXCL12-activated CXCR4 Signaling Pathway Myelin Maintenance Symbiont Entry Into Host Cell Positive Regulation Of Oligodendrocyte Differentiation Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vasculature Development Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		Branched-chain amino acid catabolism Utilization of Ketone Bodies Synthesis of Ketone Bodies Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle Beta-ketothiolase deficiency	Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Formation of definitive endoderm Specification of primordial germ cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs		Sulfasalazine Cannabidiol Medical Cannabis Nabiximols	Baclofen Framycetin AMD-070 Plerixafor Ulocuplumab Ibalizumab MSX-122
Diseases		None	Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS		Nonunion in individuals with fractures ( 30680360 ) Refractive error ( 32231278 )	Albumin-globulin ratio ( 29403010 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Arthritis (juvenile idiopathic) ( 27005825 ) Attention deficit hyperactivity disorder ( 32595297 ) Body mass index ( 26426971 ) Colorectal cancer ( 29228715 ) Estimated glomerular filtration rate ( 31152163 ) Lung function (low FEV1 vs high FEV1) ( 26423011 ) Monocyte count ( 32888494 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 ) Multiple sclerosis ( 19525953 31604244 ) Non-albumin protein levels ( 29403010 ) Smoking status (ever vs never smokers) ( 30643258 ) Telomere length ( 20421499 ) White blood cell count ( 32888494 )
Novel Interactors		1 novel interactors: CXCR4	9 novel interactors: ACAT1 AGO3 CDRT15P3 CLCN5 COL4A1 DHX57 FTO RALB SCAMP2
Interacting Genes		4 interacting genes: AGXT PDP1 PEX7 PTPRF	34 interacting genes: ARRB2 ATP13A2 B2M CCR5 CD4 CTSG CXCL12 DPP4 DUXAP9 ELANE GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RNF113A SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		38	7852
HPRD ID		01946	01217
Ensembl ID		ENSG00000075239	ENSG00000121966
Uniprot IDs		A0A140VJX1 A0A5F9ZHJ0 A0A5F9ZHL1 A0A5F9ZI66 P24752	A0A0U3FJG0 A0A0U3GXA9 A0A8Q3WLL1 P61073
PDB IDs		2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY	2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS 8GP3 8I0Q 8K3Z 8U4N 8U4O 8U4P 8U4Q 8U4R 8U4S 8U4T 8YU7 8ZPL 8ZPM 8ZPN
GO Terms Enriched among Interactors		Peroxisomal Matrix L-serine-pyruvate Transaminase Activity Peroxisome Matrix Targeting Signal-2 Binding Chondroitin Sulfate Proteoglycan Binding Protein Dephosphorylation C-X-C Motif Chemokine 12 Receptor Activity Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Glycine Biosynthetic Process, By Transamination Of Glyoxylate Peroxisome Oxalic Acid Secretion Dephosphorylation Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Phosphoprotein Phosphatase Activity Glycine Biosynthetic Process Glyoxylate Catabolic Process L-alanine Catabolic Process Alanine-glyoxylate Transaminase Activity L-alanine Metabolic Process L-cysteine Catabolic Process Cell Migration Negative Regulation Of Receptor Binding Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway [pyruvate Dehydrogenase (acetyl-transferring)]-phosphatase Activity Carboxylic Acid Catabolic Process CXCL12-activated CXCR4 Signaling Pathway Cell Motility Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Myosin Light Chain Binding C-X-C Chemokine Receptor CXCR4 Signaling Pathway Oxalate Transport Glyoxylate Metabolic Process Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Peptidyl-threonine Dephosphorylation Protein Targeting To Peroxisome Regulation Of Acyl-CoA Biosynthetic Process Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process Ether Lipid Biosynthetic Process Glycine Metabolic Process Aldehyde Catabolic Process Amino Acid Binding L-serine Metabolic Process Protein Import Into Peroxisome Matrix Myelin Maintenance Cation Binding Transmembrane Receptor Protein Tyrosine Phosphatase Activity Dendritic Cell Chemotaxis	Regulation Of Cell-cell Adhesion Cytokine-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via STAT Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Adhesion Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Regulation Of Defense Response Positive Regulation Of T Cell Activation Response To Stress Defense Response Positive Regulation Of Immune System Process Interleukin-9-mediated Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Response To Other Organism Cell Activation Immune System Process Negative Regulation Of Leukocyte Cell-cell Adhesion Response To External Biotic Stimulus Regulation Of Cytokine Production Interleukin-15-mediated Signaling Pathway Leukocyte Activation Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Cell Migration Regulation Of Leukocyte Proliferation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Population Proliferation Negative Regulation Of Leukocyte Activation Positive Regulation Of Cell Activation Leukocyte Mediated Cytotoxicity T Cell Activation Negative Regulation Of T Cell Activation Positive Regulation Of Immune Response Regulation Of Developmental Process Interleukin-6-mediated Signaling Pathway Regulation Of Multicellular Organismal Process