AGXT and TRAPPC14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AGXT	TRAPPC14
Description		alanine--glyoxylate aminotransferase	trafficking protein particle complex subunit 14
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Matrix Cytosol	Cytoplasm Spindle Cytoskeleton Plasma Membrane Midbody Vesicle Centriolar Satellite Mitotic Spindle TRAPPII Protein Complex
	Molecular Function	L-serine-pyruvate Transaminase Activity Protein Binding Alanine-glyoxylate Transaminase Activity Transaminase Activity Amino Acid Binding Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Alpha-tubulin Binding
	Biological Process	L-serine Metabolic Process Notch Signaling Pathway Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-cysteine Catabolic Process L-alanine Catabolic Process Glyoxylate Metabolic Process Oxalic Acid Secretion	Cell Projection Organization Regulation Of Cell Population Proliferation Cilium Assembly
Pathways		Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs		Pyridoxal phosphate Serine Glycine Alanine Aminooxyacetic acid N(6)-(pyridoxal phosphate)-L-lysine 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
Diseases		Primary hyperoxaluria (HP)
GWAS		Height ( 25282103 31562340) Urinary metabolites ( 26352407)
Interacting Genes		39 interacting genes: ACAT1 ACTMAP ATXN1L BATF3 CFAP68 CHIC2 CYSRT1 EFS FAM168B FHL5 FNTB FOSB GLP1R HOXA1 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP12-3 KRTAP3-1 KRTAP6-3 KRTAP8-1 KRTAP9-2 LPXN MDFI MORN5 NBPF19 NOTCH2NLA OIP5 PEX5 PLA2G10 PRDM6 PRICKLE4 RFX6 SNCAIP SPRYD7 TRAPPC14 TTC19	8 interacting genes: AGXT CYSRT1 KRTAP6-1 NBPF19 NOTCH2NLA TGM1 TMEM50A VWC2
Entrez ID		189	55262
HPRD ID		05048	07716
Ensembl ID		ENSG00000172482	ENSG00000146826
Uniprot IDs		P21549	B3KNS5 Q8WVR3
PDB IDs		1H0C 1J04 2YOB 3R9A 4CBR 4CBS 4I8A 4KXK 4KYO 5F9S 5HHY 5LUC 5OFY 5OG0 6RV0 6RV1 7NS7
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Negative Regulation Of B Cell Receptor Signaling Pathway	Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-serine-pyruvate Transaminase Activity Oxalic Acid Secretion Cornified Envelope Positive Regulation Of Cell Cycle Keratinization Cell Envelope Organization Set3 Complex Positive Regulation Of Cell Cycle G1/S Phase Transition Rpd3L-Expanded Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle RNA 5'-gamma-phosphate Methyltransferase Activity Glycine Biosynthetic Process Notch Signaling Pathway Glyoxylate Catabolic Process L-alanine Catabolic Process Alanine-glyoxylate Transaminase Activity L-alanine Metabolic Process L-cysteine Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP SnRNA Modification Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle O-methyltransferase Activity Interstitial Matrix Oxalate Transport Glyoxylate Metabolic Process Extrinsic Component Of Postsynaptic Membrane Regulation Of Cell Cycle G1/S Phase Transition 7SK SnRNA Binding Positive Regulation Of Protein Localization To Cajal Body Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process SnRNA Binding
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