AGXT and BATF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AGXT	BATF3
Description		alanine--glyoxylate aminotransferase	basic leucine zipper ATF-like transcription factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Matrix Cytosol	Chromatin Nucleus Nucleoplasm Nucleolus Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	L-serine-pyruvate Transaminase Activity Protein Binding Alanine-glyoxylate Transaminase Activity Transaminase Activity Amino Acid Binding Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding Protein Homodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	L-serine Metabolic Process Notch Signaling Pathway Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-cysteine Catabolic Process L-alanine Catabolic Process Glyoxylate Metabolic Process Oxalic Acid Secretion	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Virus Myeloid Dendritic Cell Differentiation Dendritic Cell Differentiation Integrated Stress Response Signaling
Pathways		Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs		Pyridoxal phosphate Serine Glycine Alanine Aminooxyacetic acid N(6)-(pyridoxal phosphate)-L-lysine 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
Diseases		Primary hyperoxaluria (HP)
GWAS		Height ( 25282103 31562340) Urinary metabolites ( 26352407)	Asthma ( 32296059) Leprosy ( 25642632) Multiple sclerosis ( 31604244) Thiopurine-induced leukopenia in inflammatory bowel disease (conditioned on rs116855232) ( 29923122) Type 1 diabetes ( 34012112)
Interacting Genes		39 interacting genes: ACAT1 ACTMAP ATXN1L BATF3 CFAP68 CHIC2 CYSRT1 EFS FAM168B FHL5 FNTB FOSB GLP1R HOXA1 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP12-3 KRTAP3-1 KRTAP6-3 KRTAP8-1 KRTAP9-2 LPXN MDFI MORN5 NBPF19 NOTCH2NLA OIP5 PEX5 PLA2G10 PRDM6 PRICKLE4 RFX6 SNCAIP SPRYD7 TRAPPC14 TTC19	21 interacting genes: AGXT APPL1 ATF3 ATF4 BACH2 BATF CEBPA CEBPE CEBPG CRK DBP DDIT3 EPAS1 FOSL1 GPATCH2L MAFF MAFG NFATC2IP PGR RHOXF2 STAT3
Entrez ID		189	55509
HPRD ID		05048	18081
Ensembl ID		ENSG00000172482	ENSG00000123685
Uniprot IDs		P21549	Q9NR55
PDB IDs		1H0C 1J04 2YOB 3R9A 4CBR 4CBS 4I8A 4KXK 4KYO 5F9S 5HHY 5LUC 5OFY 5OG0 6RV0 6RV1 7NS7
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Negative Regulation Of B Cell Receptor Signaling Pathway	RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Integrated Stress Response Signaling Chromatin Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Identical Protein Binding Regulation Of Metabolic Process CHOP-ATF3 Complex CHOP-ATF4 Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Epithelial Cell Maturation RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Intracellular Signaling Cassette CHOP-C/EBP Complex Transcription Regulator Complex DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Myeloid Cell Differentiation Transcription Cis-regulatory Region Binding Developmental Process GDF15-GFRAL Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Cytokine Production MRNA Transcription By RNA Polymerase II Cellular Developmental Process
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