KCNQ2 and ARIH2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KCNQ2	ARIH2
Gene Name		potassium channel, voltage gated KQT-like subfamily Q, member 2	ariadne RBR E3 ubiquitin protein ligase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Node Of Ranvier Axon Initial Segment	Nucleus Cytoplasm
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Ankyrin Binding	Nucleic Acid Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Potassium Ion Transport Synaptic Transmission Nervous System Development Axon Guidance Transmission Of Nerve Impulse Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport	Protein Polyubiquitination Multicellular Organismal Development Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation
Pathways		Interaction between L1 and Ankyrins Axon guidance Potassium Channels L1CAM interactions Voltage gated Potassium channels	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		Amitriptyline Diclofenac Meclofenamic acid Ezogabine
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ARIH2 CALM1 CALM2 CALM3 KCNQ3 PRKCA	44 interactors: ARAP1 BUB1 CBR3 CCDC33 CUL5 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R KAT5 KCNQ2 KIAA1377 LOC147791 NEDD8 PHF7 PPP2R1A PTN REL RHEB RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91
Entrez ID		3785	10425
HPRD ID		03757	09286
Ensembl ID		ENSG00000075043	ENSG00000177479
Uniprot IDs		O43526 Q4VXP7 Q53Y30	O95376 Q6IBL8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Rhodopsin Mediated Signaling Pathway Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Lyase Activity Regulation Of High Voltage-gated Calcium Channel Activity Activation Of Phospholipase C Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Phospholipase Activity Phototransduction, Visible Light Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Detection Of Calcium Ion Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lipase Activity Detection Of Visible Light Regulation Of Cell Communication By Electrical Coupling Cellular Response To Light Stimulus Phototransduction Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of CAMP Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Light Stimulus Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Energy Reserve Metabolic Process Positive Regulation Of Monooxygenase Activity Cellular Response To Radiation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cell Cycle Process ISG15-protein Conjugation Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Toll-like Receptor 4 Signaling Pathway Protein Monoubiquitination Cell Cycle Toll-like Receptor Signaling Pathway Mitotic Cell Cycle Process Pattern Recognition Receptor Signaling Pathway Mitotic Cell Cycle Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stimulus Response To Stimulus Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Proteolysis Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Mitotic Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Immune Response Regulation Of Cell Cycle Phase Transition
Tagcloud ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss magi2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28	aldo1 anxa2 cdna cerebral characterize coding cortical ddit3 egr1 endoplasmic ero1l fold gadd153 gas5 giig11 gpi1 hig1 hypoxia microarray ndr1 neuronal p4hb profiling reinforce repressed reticulum sac1p ubiquitination vdac2
Tagcloud (Difference) ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss magi2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28	aldo1 anxa2 cdna cerebral characterize coding cortical ddit3 egr1 endoplasmic ero1l fold gadd153 gas5 giig11 gpi1 hig1 hypoxia microarray ndr1 neuronal p4hb profiling reinforce repressed reticulum sac1p ubiquitination vdac2
Tagcloud (Intersection) ?