KCNQ2

Name	potassium voltage-gated channel subfamily Q member 2
Structure
Interactors	8 interactors: ARIH2 BTG3 CALM1 CALM2 CALM3 GRIK1 KCNQ3 PRKCA
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Node Of Ranvier Monoatomic Ion Channel Complex Axon Initial Segment Synapse
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Calmodulin Binding Voltage-gated Monoatomic Cation Channel Activity Ankyrin Binding
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Chemical Synaptic Transmission Nervous System Development Monoatomic Ion Transmembrane Transport Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways	Voltage gated Potassium channels Interaction between L1 and Ankyrins
Drugs	Enflurane Amitriptyline Meclofenamic acid Promethazine Miconazole Ezogabine ICA-105665
Diseases	Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS	Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Perceived intensity of neohesperidin dihydrochalcone ( 31005972 )
Entrez ID	3785
HPRD ID	03757
Ensembl ID	ENSG00000075043
Uniprot IDs	A0A0D9SGG3 A0A9L9PXL0 O43526 Q53Y30
PDB IDs	5J03 6FEG 6FEH 7CR0 7CR1 7CR2 7CR3 7CR4 7CR7 8IJK 8IZY 8J00 8J01 8J02 8J03 8J04 8J05 8W4U 8X43 8XO1
GO Terms Enriched among Interactors ?	Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Voltage-gated Potassium Channel Complex Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Calcium Channel Complex Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcineurin-mediated Signaling Presynaptic Cytosol Response To Calcium Ion Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Calcium-mediated Signaling Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Modulation Of Chemical Synaptic Transmission Calcium Channel Regulator Activity Sperm Midpiece Regulation Of Synaptic Plasticity Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sarcomere Cell Cycle G2/M Phase Transition Regulation Of Action Potential Neural Nucleus Development Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Muscle System Process Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Voltage-gated Calcium Channel Activity Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol