KCNQ2 and CALM3

Number of citations of the paper that reports this interaction (PMID 12032157)
40

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		KCNQ2	CALM3
Gene Name		potassium channel, voltage gated KQT-like subfamily Q, member 2	calmodulin 3 (phosphorylase kinase, delta)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Node Of Ranvier Axon Initial Segment	Spindle Pole Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Spindle Microtubule Plasma Membrane Sarcomere Growth Cone Vesicle Calcium Channel Complex Extracellular Vesicular Exosome
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Ankyrin Binding	Calcium Ion Binding Protein Binding Adenylate Cyclase Binding Protein Kinase Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Titin Binding Type 3 Metabotropic Glutamate Receptor Binding Thioesterase Binding N-terminal Myristoylation Domain Binding Phospholipase Binding Protein Serine/threonine Kinase Activator Activity Phosphatidylinositol 3-kinase Binding Ion Channel Binding Calcium-dependent Protein Binding Nitric-oxide Synthase Binding Protein Phosphatase Activator Activity
	Biological Process	Potassium Ion Transport Synaptic Transmission Nervous System Development Axon Guidance Transmission Of Nerve Impulse Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport	Response To Amphetamine Regulation Of Heart Rate Platelet Degranulation Detection Of Calcium Ion Carbohydrate Metabolic Process Glycogen Catabolic Process Glucose Metabolic Process Muscle Contraction Organelle Organization Mitochondrion Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Phototransduction, Visible Light Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Rhodopsin Mediated Signaling Pathway Substantia Nigra Development Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Protein Autophosphorylation Regulation Of Cytokinesis Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Fc-epsilon Receptor Signaling Pathway Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response Nitric Oxide Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Corticosterone Response To Calcium Ion Regulation Of Cardiac Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Membrane Organization Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Interaction between L1 and Ankyrins Axon guidance Potassium Channels L1CAM interactions Voltage gated Potassium channels	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Ca-dependent events CaM pathway Signaling by FGFR in disease Phospholipase C-mediated cascade Signaling by Wnt Platelet degranulation Signaling by EGFRvIII in Cancer CREB phosphorylation through the activation of Ras PLCG1 events in ERBB2 signaling Glucose metabolism DAP12 signaling Synthesis of IP3 and IP4 in the cytosol Myoclonic epilepsy of Lafora Response to elevated platelet cytosolic Ca2+ Glycogen storage diseases Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Signaling by PDGF Calmodulin induced events CaMK IV-mediated phosphorylation of CREB DAP12 interactions Glycogen breakdown (glycogenolysis) Opioid Signalling Activation of Kainate Receptors upon glutamate binding Diseases associated with visual transduction Inositol phosphate metabolism EGFR interacts with phospholipase C-gamma CaMK IV-mediated phosphorylation of CREB Signaling by ERBB2 Signaling by EGFR Signaling by VEGF CREB phosphorylation through the activation of CaMKK Downstream signal transduction Calmodulin induced events CREB phosphorylation through the activation of CaMKII Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Transcriptional activation of mitochondrial biogenesis Metabolism of carbohydrates Platelet activation, signaling and aggregation Adaptive Immune System Transmission across Chemical Synapses Ras activation uopn Ca2+ infux through NMDA receptor Organelle biogenesis and maintenance Cam-PDE 1 activation Translocation of GLUT4 to the plasma membrane VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Inactivation, recovery and regulation of the phototransduction cascade Metabolism of nitric oxide VEGFR2 mediated cell proliferation VEGFR2 mediated vascular permeability Activation of NMDA receptor upon glutamate binding and postsynaptic events The phototransduction cascade Downstream signaling of activated FGFR DARPP-32 events eNOS activation and regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Post NMDA receptor activation events Signalling by NGF PLC beta mediated events Smooth Muscle Contraction Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Mitochondrial biogenesis beta-catenin independent WNT signaling Signaling by FGFR eNOS activation Cam-PDE 1 activation Ca2+ pathway Visual phototransduction Activation of CaMK IV PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs		Amitriptyline Diclofenac Meclofenamic acid Ezogabine	Dibucaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine 3\'\'-(Beta-Chloroethyl)-2\'\',4\'\'-Dioxo-3, 5\'\'-Spiro-Oxazolidino-4-Deacetoxy-Vinblastine 2-Methyl-2-Propanol N-Trimethyllysine N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE MYRISTIC ACID
Diseases
GWAS			Ulcerative colitis ( 23128233)
Protein-Protein Interactions		6 interactors: ARIH2 CALM1 CALM2 CALM3 KCNQ3 PRKCA	35 interactors: AKAP9 APPBP2 ASCL2 C11orf65 CACNA1A CALD1 CAMTA2 CCND2 CCP110 CLEC7A EDF1 EGFR ESR1 ESR2 GRM5 GRM7 INSR IQCE KCNQ2 KCNQ3 KCNQ5 KIAA1683 MINK1 MYF5 MYF6 MYOD1 MYOG NEUROD1 PLCB3 PPEF1 PPEF2 RAB3B TCF3 TCF4 TRIM54
Entrez ID		3785	808
HPRD ID		03757	00243
Ensembl ID		ENSG00000075043	ENSG00000160014
Uniprot IDs		O43526 Q4VXP7 Q53Y30	B4DJ51 P62158 Q96HY3 Q9BRL5
PDB IDs			1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M55 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4DCK 4DJC 4GOW
Enriched GO Terms of Interacting Partners?		Regulation Of Rhodopsin Mediated Signaling Pathway Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Lyase Activity Regulation Of High Voltage-gated Calcium Channel Activity Activation Of Phospholipase C Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Phospholipase Activity Phototransduction, Visible Light Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Detection Of Calcium Ion Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lipase Activity Detection Of Visible Light Regulation Of Cell Communication By Electrical Coupling Cellular Response To Light Stimulus Phototransduction Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of CAMP Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Light Stimulus Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Energy Reserve Metabolic Process Positive Regulation Of Monooxygenase Activity Cellular Response To Radiation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity	Positive Regulation Of Skeletal Muscle Fiber Development Cell-cell Signaling Synaptic Transmission Cell Differentiation Muscle Cell Fate Commitment Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion Cellular Response To Estradiol Stimulus Tissue Development Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Positive Regulation Of Cellular Metabolic Process Regulation Of Skeletal Muscle Tissue Development Cellular Response To Estrogen Stimulus Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Cell Development Cell Fate Commitment Transcription From RNA Polymerase II Promoter Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Myotube Differentiation Regulation Of Cellular Process Multicellular Organismal Development Positive Regulation Of Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Cell Development Regulation Of Myoblast Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Positive Regulation Of Transcription, DNA-templated Cell Communication System Development Epithelium Development Regulation Of Ion Transmembrane Transport Regulation Of Striated Muscle Tissue Development Regulation Of Ion Transport Regulation Of Myotube Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Metabolic Process Anatomical Structure Development Developmental Process Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Differentiation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Positive Regulation Of Gene Expression Signaling
Tagcloud ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss magi2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28	cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss magi2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28	cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?