KCNQ2 and KCNQ3

Number of citations of the paper that reports this interaction (PMID 12524525)
32

Data Source:
HPRD (in vivo)

		KCNQ2	KCNQ3
Gene Name		potassium channel, voltage gated KQT-like subfamily Q, member 2	potassium channel, voltage gated KQT-like subfamily Q, member 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Node Of Ranvier Axon Initial Segment	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Node Of Ranvier Axon Initial Segment
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Ankyrin Binding	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity
	Biological Process	Potassium Ion Transport Synaptic Transmission Nervous System Development Axon Guidance Transmission Of Nerve Impulse Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport	Potassium Ion Transport Synaptic Transmission Axon Guidance Regulation Of Ion Transmembrane Transport Membrane Hyperpolarization Potassium Ion Transmembrane Transport
Pathways		Interaction between L1 and Ankyrins Axon guidance Potassium Channels L1CAM interactions Voltage gated Potassium channels	Interaction between L1 and Ankyrins Axon guidance Potassium Channels L1CAM interactions Voltage gated Potassium channels
Drugs		Amitriptyline Diclofenac Meclofenamic acid Ezogabine
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ARIH2 CALM1 CALM2 CALM3 KCNQ3 PRKCA	6 interactors: CALM1 CALM2 CALM3 KCNQ2 KCNQ4 KCNQ5
Entrez ID		3785	3786
HPRD ID		03757	09077
Ensembl ID		ENSG00000075043	ENSG00000184156
Uniprot IDs		O43526 Q4VXP7 Q53Y30	O43525
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Rhodopsin Mediated Signaling Pathway Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Lyase Activity Regulation Of High Voltage-gated Calcium Channel Activity Activation Of Phospholipase C Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Phospholipase Activity Phototransduction, Visible Light Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Detection Of Calcium Ion Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lipase Activity Detection Of Visible Light Regulation Of Cell Communication By Electrical Coupling Cellular Response To Light Stimulus Phototransduction Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of CAMP Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Light Stimulus Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Energy Reserve Metabolic Process Positive Regulation Of Monooxygenase Activity Cellular Response To Radiation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity	Regulation Of Ion Transmembrane Transport Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Synaptic Transmission Regulation Of Ion Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Cell-cell Signaling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Positive Regulation Of Phosphatase Activity Response To Corticosterone Positive Regulation Of Cation Channel Activity Response To Amphetamine Positive Regulation Of Adenylate Cyclase Activity Regulation Of Phosphoprotein Phosphatase Activity Response To Mineralocorticoid Regulation Of Nitric-oxide Synthase Activity Substantia Nigra Development Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Positive Regulation Of Lyase Activity Positive Regulation Of Dephosphorylation Negative Regulation Of Ion Transmembrane Transport
Tagcloud ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss magi2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28	camk1 centriole dkk1 enah endosome geo gpsm2 inference kpna2 lcn2 lef1 lysosome map2k6 multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 sstr5 stx1a subnetwork tbl3 transport tshb ube2c
Tagcloud (Difference) ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss magi2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28	camk1 centriole dkk1 enah endosome geo gpsm2 inference kpna2 lcn2 lef1 lysosome map2k6 multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 sstr5 stx1a subnetwork tbl3 transport tshb ube2c
Tagcloud (Intersection) ?