KCNQ2 and KCNQ3

Number of citations of the paper that reports this interaction (PubMedID 12524525)
27

Data Source:
HPRD (in vivo)

		KCNQ2	KCNQ3
Description		potassium voltage-gated channel subfamily Q member 2	potassium voltage-gated channel subfamily Q member 3
Image
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Node Of Ranvier Monoatomic Ion Channel Complex Axon Initial Segment Synapse	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Node Of Ranvier Monoatomic Ion Channel Complex Axon Initial Segment Synapse
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Calmodulin Binding Voltage-gated Monoatomic Cation Channel Activity Ankyrin Binding	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Calmodulin Binding Voltage-gated Monoatomic Cation Channel Activity
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Chemical Synaptic Transmission Nervous System Development Monoatomic Ion Transmembrane Transport Transmembrane Transport Potassium Ion Transmembrane Transport	Protein Targeting Protein Import Into Nucleus Monoatomic Ion Transport Potassium Ion Transport Exocytosis Endocytosis Chemical Synaptic Transmission Sensory Perception Of Sound Response To Mechanical Stimulus Gene Expression Response To Auditory Stimulus Protein Transport Neuron Remodeling Neuronal Action Potential Nerve Development Neuron Differentiation Monoatomic Ion Transmembrane Transport Psychomotor Behavior Regulation Of Synaptic Plasticity Neuron Apoptotic Process Establishment Of Localization In Cell Mitochondrial Depolarization Transmembrane Transport Membrane Hyperpolarization Protein-containing Complex Assembly Cellular Response To Calcium Ion Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Apoptosome Assembly Excitatory Chemical Synaptic Transmission Inhibitory Chemical Synaptic Transmission Action Potential Initiation Regulation Of Action Potential Firing Threshold Substantia Propria Of Cornea Development
Pathways		Voltage gated Potassium channels Interaction between L1 and Ankyrins	Voltage gated Potassium channels Interaction between L1 and Ankyrins
Drugs		Enflurane Amitriptyline Meclofenamic acid Promethazine Miconazole Ezogabine ICA-105665	Enflurane Amitriptyline Meclofenamic acid Gabapentin Promethazine Miconazole Ezogabine ICA-105665
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Perceived intensity of neohesperidin dihydrochalcone ( 31005972)	Coronary artery calcification ( 23870195) Height ( 28552196) LDL peak particle diameter (total fat intake interaction) ( 26112879) QT interval ( 29213071) Type 2 diabetes ( 31324766)
Interacting Genes		8 interacting genes: ARIH2 BTG3 CALM1 CALM2 CALM3 GRIK1 KCNQ3 PRKCA	6 interacting genes: CALM1 CALM2 CALM3 KCNQ2 KCNQ4 KCNQ5
Entrez ID		3785	3786
HPRD ID		03757	09077
Ensembl ID		ENSG00000075043	ENSG00000184156
Uniprot IDs		A0A0D9SGG3 A0A9L9PXL0 O43526 Q53Y30	E7ET42 O43525
PDB IDs		5J03 6FEG 6FEH 7CR0 7CR1 7CR2 7CR3 7CR4 7CR7 8IJK 8IZY 8J00 8J01 8J02 8J03 8J04 8J05 8W4U 8X43 8XO1	5J03
Enriched GO Terms of Interacting Partners?		Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Voltage-gated Potassium Channel Complex Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Calcium Channel Complex Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcineurin-mediated Signaling Presynaptic Cytosol Response To Calcium Ion Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Calcium-mediated Signaling Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Modulation Of Chemical Synaptic Transmission Calcium Channel Regulator Activity Sperm Midpiece Regulation Of Synaptic Plasticity Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sarcomere Cell Cycle G2/M Phase Transition Regulation Of Action Potential Neural Nucleus Development Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Muscle System Process Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Voltage-gated Calcium Channel Activity Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol	Voltage-gated Potassium Channel Complex Calyx Of Held Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Catalytic Complex Negative Regulation Of Transporter Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Transmembrane Transport Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Response To Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Potassium Channel Activity Long-term Synaptic Potentiation Sarcomere Cell Cycle G2/M Phase Transition Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neural Nucleus Development Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Voltage-gated Calcium Channel Activity Potassium Channel Activity Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity
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