KCNJ10 and PATJ

Number of citations of the paper that reports this interaction (PubMedID 9647694)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		KCNJ10	PATJ
Description		potassium inwardly rectifying channel subfamily J member 10	PATJ crumbs cell polarity complex component
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Monoatomic Ion Channel Complex Cell Body Astrocyte Projection Ciliary Base Presynapse	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Centriolar Satellite Apical Junction Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Tight Junction Anchoring Junction
	Molecular Function	Nucleotide Binding Inward Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity	Protein Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Visual Perception Adult Walking Behavior Oligodendrocyte Development Central Nervous System Myelination Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Potassium Ion Regulation Of Membrane Potential Regulation Of Long-term Neuronal Synaptic Plasticity Establishment Of Localization In Cell Glutamate Reuptake Potassium Ion Homeostasis Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Non-motile Cilium Assembly Potassium Ion Import Across Plasma Membrane	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tight Junction Assembly
Pathways		Activation of G protein gated Potassium channels Potassium transport channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs		Ritodrine Yohimbine Butamben
Diseases		Seizures-sensorineural deafness-ataxia-mental retardation-electrolyte imbalance (SESAME) ; SeSAME/EAST syndrome
GWAS			3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Autism spectrum disorders (social interaction) ( 32624584) Daytime nap ( 33568662) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)
Interacting Genes		9 interacting genes: APP DLG1 DLG4 IL16 KCNJ16 PATJ SIAH1 SNCA SNTA1	35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3
Entrez ID		3766	10207
HPRD ID		03732	04434
Ensembl ID		ENSG00000177807	ENSG00000132849
Uniprot IDs		P78508	A0A2R8Y549 Q8NI35
PDB IDs			1VF6 2D92 2DAZ 2DB5 2DLU 2DM8 2DMZ 2EHR 4Q2N 6IRD
Enriched GO Terms of Interacting Partners?		Regulation Of Monoatomic Ion Transport Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Monoatomic Ion Transmembrane Transport Amyloid Fibril Formation Regulation Of Metal Ion Transport Regulation Of Membrane Potential Regulation Of Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Neuronal Synaptic Plasticity NMDA Selective Glutamate Receptor Signaling Pathway Synaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Neuromuscular Junction Chemical Synaptic Transmission Trans-synaptic Signaling Acetylcholine Receptor Binding Synaptic Signaling Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Synaptic Transmission Regulation Of Neurotransmitter Uptake Cell Junction Organization Cellular Response To Copper Ion Establishment Or Maintenance Of Cell Polarity Regulation Of Presynapse Organization Positive Regulation Of Inflammatory Response Regulation Of Presynapse Assembly Cellular Response To Metal Ion Supramolecular Fiber Organization Ionotropic Glutamate Receptor Signaling Pathway Microglial Cell Activation Ionotropic Glutamate Receptor Binding Locomotory Behavior Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of System Process Leukocyte Activation Involved In Inflammatory Response Protein Localization To Postsynaptic Membrane Cell Junction Protein Localization To Postsynapse Regulation Of Synaptic Plasticity Response To Copper Ion Plasma Membrane Cell-cell Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Presynapse Postsynapse Ligand-gated Ion Channel Signaling Pathway Signaling Regulation Of Cell Activation	Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Channel Activity Regulation Of Synaptic Transmission, Glutamatergic NMDA Glutamate Receptor Activity Metal Ion Transport NMDA Selective Glutamate Receptor Complex Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Monoatomic Ion Channel Complex Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Modulation Of Chemical Synaptic Transmission Monoatomic Ion Channel Activity Modulation Of Excitatory Postsynaptic Potential System Process Glutamate Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Neuronal Synaptic Plasticity Monoatomic Ion Transport Protein Localization To Synapse Regulation Of Nervous System Process Chemical Synaptic Transmission Trans-synaptic Signaling Postsynaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Synaptic Signaling Positive Regulation Of Synaptic Transmission Dendritic Spine Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Plasma Membrane Transmembrane Transport Regulation Of System Process Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Glutamatergic Synapse Synapse Ligand-gated Ion Channel Signaling Pathway Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Protein Localization To Membrane Regulation Of Synaptic Plasticity Dendrite Membrane Depolarization Long-term Synaptic Potentiation
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