KCNH1 and KCNH5

Number of citations of the paper that reports this interaction (PubMedID 11943152)
0

Data Source:
HPRD (in vitro)

		KCNH1	KCNH5
Description		potassium voltage-gated channel subfamily H member 1	potassium voltage-gated channel subfamily H member 5
Image
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Dendrite Early Endosome Membrane Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Perikaryon Synapse Postsynaptic Membrane Postsynaptic Density Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Monoatomic Ion Channel Complex
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Calmodulin Binding Lipid Binding Cyclic Nucleotide Binding Phosphatidylinositol Bisphosphate Binding	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Calmodulin Binding Transmembrane Transporter Binding Protein-containing Complex Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Myoblast Fusion Monoatomic Ion Transmembrane Transport Regulation Of Cell Population Proliferation Regulation Of Membrane Potential Transmembrane Transport Cellular Response To Calcium Ion Potassium Ion Transmembrane Transport	Monoatomic Ion Transport Potassium Ion Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Voltage gated Potassium channels	Voltage gated Potassium channels
Drugs		Enflurane Imipramine Astemizole Promethazine Miconazole	Enflurane Promethazine Miconazole
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Bone mineral density (femoral neck) ( 27424934) Bone mineral density (spine) and age at menarche ( 26312577) Bone mineral density (total hip) ( 27424934) Cancer ( 27197191) Cholesterol ( 31902109) Circulating vasoactive peptide levels ( 23381795) Cobalt levels ( 26025379) Hematocrit ( 32888494) Hemoglobin ( 32888494) L1-L4 bone mineral density x serum urate levels interaction ( 34046847)	Body mass index ( 24348519) Cotinine glucuronidation ( 25293881) Femur bone mineral density x serum urate levels interaction ( 34046847) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Response to protease inhibitor treatment in hepatitis c (bilirubin toxicity) ( 24503447) Sleep duration ( 30531941) Subcutaneous adipose tissue ( 22589738)
Interacting Genes		11 interacting genes: ALG10 CALM1 FASTKD5 KCNB1 KCNC1 KCNF1 KCNH5 MKRN1 MTDH NTAQ1 SDCBP	1 interacting genes: KCNH1
Entrez ID		3756	27133
HPRD ID		04492	10421
Ensembl ID		ENSG00000143473	ENSG00000140015
Uniprot IDs		O95259	Q8NCM2
PDB IDs		5J7E	7YID 7YIE 7YIF 7YIG 7YIH 7YIJ
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Monoatomic Ion Channel Complex Transmembrane Transporter Binding Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Regulation Of Membrane Potential Action Potential Calyx Of Held Neuronal Cell Body Membrane Dendrite Membrane Protein Homooligomerization Potassium Channel Regulator Activity Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Protein Complex Oligomerization Regulation Of Action Potential Interleukin-5 Receptor Complex Protein-N-terminal Glutamine Amidohydrolase Activity Inorganic Ion Transmembrane Transport Neural Nucleus Development Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Metal Ion Transport Response To Metal Ion Organelle Localization By Membrane Tethering Positive Regulation Of Exocytosis Regulation Of Potassium Ion Transport Interleukin-5 Receptor Binding Protein-N-terminal Asparagine Amidohydrolase Activity Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity Membrane Docking Regulation Of Transport Positive Regulation Of Norepinephrine Secretion Monoatomic Ion Transport Globus Pallidus Development Gated Channel Activity Neuron Projection Membrane Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Regulation Of Biological Quality	Cyclic Nucleotide Binding Cell-cell Fusion Delayed Rectifier Potassium Channel Activity Syncytium Formation By Plasma Membrane Fusion Myoblast Fusion Phosphatidylinositol Bisphosphate Binding Syncytium Formation Voltage-gated Potassium Channel Activity Nuclear Inner Membrane Potassium Channel Activity Voltage-gated Potassium Channel Complex Cellular Response To Calcium Ion Postsynaptic Density Membrane Potassium Ion Transmembrane Transport Perikaryon Monoatomic Ion Channel Activity Cellular Response To Metal Ion Potassium Ion Transport Presynaptic Membrane Response To Calcium Ion Monoatomic Ion Channel Complex Early Endosome Membrane Calmodulin Binding Postsynaptic Membrane Response To Metal Ion Lipid Binding
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