KCNH1 and KCNC1

Number of citations: 35 (PubMedID 12060745)
Data Source: BioGRID (two hybrid)

		KCNH1	KCNC1
Name		potassium voltage-gated channel subfamily H member 1	potassium voltage-gated channel subfamily C member 1
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Dendrite Early Endosome Membrane Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Perikaryon Synapse Postsynaptic Membrane Postsynaptic Density Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Axon Dendrite Axolemma Neuron Projection Membrane Dendrite Membrane Neuronal Cell Body Membrane Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Axon Terminus Calyx Of Held Synapse Postsynaptic Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Calmodulin Binding Lipid Binding Cyclic Nucleotide Binding Phosphatidylinositol Bisphosphate Binding	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Kinesin Binding Gated Channel Activity Transmembrane Transporter Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Myoblast Fusion Monoatomic Ion Transmembrane Transport Regulation Of Cell Population Proliferation Regulation Of Membrane Potential Transmembrane Transport Cellular Response To Calcium Ion Potassium Ion Transmembrane Transport	Action Potential Monoatomic Ion Transport Potassium Ion Transport Response To Toxic Substance Response To Light Intensity Response To Auditory Stimulus Response To Amine Cerebellum Development Optic Nerve Development Globus Pallidus Development Corpus Callosum Development Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Response To Potassium Ion Protein Homooligomerization Protein Tetramerization Transmembrane Transport Cellular Response To Xenobiotic Stimulus Response To Fibroblast Growth Factor Potassium Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Response To Nerve Growth Factor
Pathways		Voltage gated Potassium channels	Voltage gated Potassium channels
Drugs		Enflurane Imipramine Astemizole Promethazine Miconazole	Enflurane Promethazine Miconazole Dalfampridine
GWAS		Blond vs. brown/black hair color ( 30531825 ) Bone mineral density (femoral neck) ( 27424934 ) Bone mineral density (spine) and age at menarche ( 26312577 ) Bone mineral density (total hip) ( 27424934 ) Cancer ( 27197191 ) Cholesterol ( 31902109 ) Circulating vasoactive peptide levels ( 23381795 ) Cobalt levels ( 26025379 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 )	Body mass index ( 26426971 ) Night sleep phenotypes ( 27126917 ) Opioid sensitivity ( 24143882 )
Interacting Genes		11 interacting genes: ALG10 CALM1 FASTKD5 KCNB1 KCNC1 KCNF1 KCNH5 MKRN1 MTDH NTAQ1 SDCBP	7 interacting genes: ANK3 KCNG3 KCNH1 KCNV2 LPAR3 TMBIM6 TRARG1
Entrez ID		3756	3746
HPRD ID		04492	15936
Ensembl ID		ENSG00000143473	ENSG00000129159
Uniprot IDs		O95259	P48547
PDB IDs		5J7E	7PHH 7PHI 7PHK 7PHL 7PQT 7PQU 8F1C 8F1D 8QUC 8QUD
GO Terms Enriched among Interactors		Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Monoatomic Ion Channel Complex Transmembrane Transporter Binding Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Regulation Of Membrane Potential Action Potential Calyx Of Held Neuronal Cell Body Membrane Dendrite Membrane Protein Homooligomerization Potassium Channel Regulator Activity Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Protein Complex Oligomerization Regulation Of Action Potential Interleukin-5 Receptor Complex Protein-N-terminal Glutamine Amidohydrolase Activity Inorganic Ion Transmembrane Transport Neural Nucleus Development Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Metal Ion Transport Response To Metal Ion Organelle Localization By Membrane Tethering Positive Regulation Of Exocytosis Regulation Of Potassium Ion Transport Interleukin-5 Receptor Binding Protein-N-terminal Asparagine Amidohydrolase Activity Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity Membrane Docking Regulation Of Transport Positive Regulation Of Norepinephrine Secretion Monoatomic Ion Transport Globus Pallidus Development Gated Channel Activity Neuron Projection Membrane Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Regulation Of Biological Quality	Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Regulation Of Metal Ion Transport Action Potential Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transport Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Biological Quality Plasma Membrane Inorganic Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Potassium Channel Regulator Activity Regulation Of Monoatomic Ion Transmembrane Transport Establishment Of Protein Localization To Plasma Membrane Monoatomic Ion Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Axon Negative Regulation Of Monoatomic Ion Transmembrane Transport Cyclic Nucleotide Binding Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane Endoribonuclease Inhibitor Activity Negative Regulation Of Transmembrane Transport Positive Regulation Of Cell Communication By Electrical Coupling Vesicle-mediated Transport To The Plasma Membrane Membrane Lysophosphatidic Acid Receptor Activity Regulation Of Transport Cellular Response To Metal Ion Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transport Into Cytosol Cellular Response To Magnesium Ion Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of IRE1-mediated Unfolded Protein Response Glucose Import In Response To Insulin Stimulus Protein Localization To Plasma Membrane