ALOX15B and CTAG1B

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ALOX15B	CTAG1B
Name		arachidonate 15-lipoxygenase type B	cancer/testis antigen 1B
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Membrane Extracellular Exosome Anchoring Junction	Cytoplasm
	Molecular Function	Iron Ion Binding Calcium Ion Binding Protein Binding Lipid Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Arachidonate 8(S)-lipoxygenase Activity Metal Ion Binding Arachidonate 15-lipoxygenase Activity Dioxygenase Activity Linoleate 9S-lipoxygenase Activity	Protein Binding Identical Protein Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Arachidonate Metabolic Process Lipoxygenase Pathway Negative Regulation Of Cell Migration Prostate Gland Development Regulation Of Epithelial Cell Differentiation Positive Regulation Of Chemokine Production Lipid Oxidation Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Linoleic Acid Metabolic Process Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Growth Hepoxilin Biosynthetic Process Endocannabinoid Signaling Pathway Cannabinoid Biosynthetic Process Lipoxin A4 Biosynthetic Process	TRNA Threonylcarbamoyladenosine Metabolic Process
Pathways		Synthesis of 15-eicosatetraenoic acid derivatives	None
GWAS		Blood protein levels ( 30072576 ) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682 ) Menarche (age at onset) ( 25231870 ) Metabolite levels ( 23823483 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: ATP6AP1
Interacting Genes		9 interacting genes: CTAG1A CTAG1B KCNF1 PPARG RARA RXRA TRAIP TRIM21 VMA22	81 interacting genes: ACTN3 AIRIM ALOX15B ARHGEF28 ATP1A4 BAG6 BEX1 BEX2 BMF BORCS8 BORCS8-MEF2B C14orf119 CAMSAP1 CCDC116 CCHCR1 CDC37 CDKN2AIPNL CHCHD2 CSTF2T CTAG1A CYTH4 DESI1 FCHSD2 FSD2 GATC GNG13 GPSM3 GTF2I GUCD1 HCK HEMK1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 KIF26A KLHL38 LAMTOR1 LNPEP LONRF3 MAGEC1 MEIS2 MGAT5B MSGN1 NAB2 NCS1 NTAQ1 P4HA3 PEF1 PIH1D2 POLM PSMB1 RANBP10 REX1BD RSRC2 RTN4IP1 RUSC1 SEC14L4 SGTA SGTB SIKE1 SMG9 SOHLH1 SPAG8 STRA8 SUOX TCEANC TEPSIN THOC1 TNPO2 TRIB3 TRIM55 TRIM63 TSGA10IP UBE2V1 UBL5 UBQLN1 UBQLN2 USP20 VENTX WWOX
Entrez ID		247	1485
HPRD ID		04739	02151
Ensembl ID		ENSG00000179593	ENSG00000184033
Uniprot IDs		O15296	P78358
PDB IDs		4NRE 7LAF 8VIY	1S9W 2BNQ 2BNR 2F53 2F54 2P5E 2P5W 2PYE 3GJF 3HAE 3KLA 6AT5 6AVF 6AVG 6RP9 6RPA 6RPB 9C3E 9DL1
GO Terms Enriched among Interactors		Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Lipoprotein Transport Nuclear Receptor Activity MRNA Transcription By RNA Polymerase II DNA Binding Domain Binding LBD Domain Binding MRNA Transcription Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Peroxisome Proliferator Activated Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Alpha-actinin Binding RNA Polymerase II Transcription Regulator Complex TRNA Threonylcarbamoyladenosine Metabolic Process Hormone-mediated Signaling Pathway Monocyte Differentiation Retinoic Acid Binding Identical Protein Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Cholesterol Efflux Peptide Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Nucleic Acid Metabolic Process Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Intracellular Receptor Signaling Pathway Protein Catabolic Process Transcription Coregulator Binding Regulation Of Cholesterol Efflux Macromolecule Metabolic Process Positive Regulation Of Binding Transcription Cis-regulatory Region Binding RNA Metabolic Process Transcription By RNA Polymerase II Regulation Of Cholesterol Transport Sertoli Cell Fate Commitment Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Positive Regulation Of Lipid Transport Enzyme Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Adiponectin Secretion Negative Regulation Of Innate Immune Response Negative Regulation Of Response To Cytokine Stimulus DNA-templated Transcription Response To Retinoic Acid Macromolecule Catabolic Process	Protein Binding Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Positive Regulation Of ERAD Pathway Antigen Processing And Presentation Of Exogenous Antigen Regulation Of ERAD Pathway MHC Class II Protein Complex Binding ER To Golgi Transport Vesicle Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Peptide Antigen Binding TRC Complex Positive Regulation Of Response To Endoplasmic Reticulum Stress Myeloid Dendritic Cell Antigen Processing And Presentation Transport Vesicle Membrane Antigen Processing And Presentation Trans-Golgi Network Membrane Skeletal Muscle Atrophy Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Proteasomal Protein Catabolic Process Clathrin-coated Endocytic Vesicle Membrane Protein Targeting To ER Regulation Of Protein Ubiquitination Skeletal Muscle Adaptation Striated Muscle Atrophy Lysosomal Membrane Endocytic Vesicle Membrane Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Autolysosome Membrane Muscle Atrophy Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell MHC Class II Receptor Activity Polyubiquitin Modification-dependent Protein Binding Late Endosome Membrane Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Post-translational Protein Modification