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DARS2 and EPHA8
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
DARS2
EPHA8
Gene Name
aspartyl-tRNA synthetase 2, mitochondrial
EPH receptor A8
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Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Mitochondrion
Mitochondrial Matrix
Plasma Membrane
Integral Component Of Plasma Membrane
Early Endosome Membrane
Neuron Projection
Molecular Function
TRNA Binding
Aspartate-tRNA Ligase Activity
Protein Binding
ATP Binding
Protein Homodimerization Activity
Aspartate-tRNA(Asn) Ligase Activity
GPI-linked Ephrin Receptor Activity
ATP Binding
Biological Process
TRNA Aminoacylation For Protein Translation
Gene Expression
TRNA Aminoacylation
Mitochondrial Asparaginyl-tRNA Aminoacylation
Substrate-dependent Cell Migration
Cell Adhesion
Axon Guidance
Neuron Remodeling
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell Adhesion
Neuron Projection Development
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Pathways
tRNA Aminoacylation
Mitochondrial tRNA aminoacylation
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Axon guidance
EPH-Ephrin signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions
4 interactors:
AIMP2
DPYSL5
EPHA8
KARS
11 interactors:
AK4
DARS2
EFNA1
EFNA4
EFNA5
FYN
G3BP1
PIK3CG
PSMC5
UBC
ZNF746
Entrez ID
55157
2046
HPRD ID
07677
01493
Ensembl ID
ENSG00000117593
ENSG00000070886
Uniprot IDs
Q6PI48
Q9H9J7
P29322
PDB IDs
4AH6
1UCV
1X5L
3KUL
Enriched GO Terms of Interacting Partners
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TRNA Aminoacylation For Protein Translation
TRNA Aminoacylation
Lysyl-tRNA Aminoacylation
Diadenosine Tetraphosphate Biosynthetic Process
TRNA Metabolic Process
Type II Pneumocyte Differentiation
Pyrimidine Nucleobase Catabolic Process
Neuron Remodeling
Axon Guidance
Lung Secretory Cell Differentiation
Cellular Amino Acid Metabolic Process
NcRNA Metabolic Process
Axonogenesis
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Small Molecule Metabolic Process
Chemotaxis
Neuron Projection Morphogenesis
Nucleobase-containing Small Molecule Metabolic Process
Translation
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Neuron Maturation
Cell Morphogenesis Involved In Differentiation
Substrate-dependent Cell Migration
Pyrimidine Nucleobase Metabolic Process
Regulation Of Cell Adhesion Mediated By Integrin
Neuron Projection Development
Cell Projection Morphogenesis
Cell Part Morphogenesis
Regulation Of Phosphatidylinositol 3-kinase Activity
Neuron Development
Lung Epithelial Cell Differentiation
Regulation Of Lipid Kinase Activity
Carboxylic Acid Metabolic Process
Lung Cell Differentiation
Cell Differentiation
Cell Morphogenesis
Lung Epithelium Development
Neuron Differentiation
Organic Acid Metabolic Process
Cell Projection Organization
Locomotion
Ephrin Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Chemotaxis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Axon Guidance
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Modification Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Signal Transduction
Axonogenesis
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Transferase Activity
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of MAP Kinase Activity
Regulation Of Signaling
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Adhesion
Locomotion
Neuron Projection Morphogenesis
Positive Regulation Of Signal Transduction
Regulation Of Cell Adhesion Mediated By Integrin
Negative Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Cell Morphogenesis Involved In Differentiation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of MAP Kinase Activity
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Wnt Signaling Pathway
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Movement Of Cell Or Subcellular Component
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Signal Transduction Involved In DNA Damage Checkpoint
Positive Regulation Of Intracellular Signal Transduction
Signal Transduction Involved In Cell Cycle Checkpoint
Neuron Projection Development
Regulation Of Cell Death
T Cell Proliferation
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Cell Projection Morphogenesis
Cell Part Morphogenesis
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Phosphorylation
Signal Transduction
Mitochondrial Asparaginyl-tRNA Aminoacylation
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
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Tagcloud (Intersection)
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