DARS2 and DPYSL5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DARS2	DPYSL5
Gene Name		aspartyl-tRNA synthetase 2, mitochondrial	dihydropyrimidinase-like 5
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix	Cytosol Dendrite Neuronal Cell Body
	Molecular Function	TRNA Binding Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides
	Biological Process	TRNA Aminoacylation For Protein Translation Gene Expression TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation	Pyrimidine Nucleobase Catabolic Process Signal Transduction Nervous System Development Axon Guidance
Pathways		tRNA Aminoacylation Mitochondrial tRNA aminoacylation	Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS			Fasting glucose-related traits (interaction with BMI) ( 22581228) Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: AIMP2 DPYSL5 EPHA8 KARS	8 interactors: APPL1 DARS2 DPYS DPYSL2 DPYSL3 DPYSL4 FES HSPA5
Entrez ID		55157	56896
HPRD ID		07677	10522
Ensembl ID		ENSG00000117593	ENSG00000157851
Uniprot IDs		Q6PI48 Q9H9J7	Q9BPU6
PDB IDs		4AH6	4B90 4B91 4B92
Enriched GO Terms of Interacting Partners?		TRNA Aminoacylation For Protein Translation TRNA Aminoacylation Lysyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process TRNA Metabolic Process Type II Pneumocyte Differentiation Pyrimidine Nucleobase Catabolic Process Neuron Remodeling Axon Guidance Lung Secretory Cell Differentiation Cellular Amino Acid Metabolic Process NcRNA Metabolic Process Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Small Molecule Metabolic Process Chemotaxis Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Translation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Neuron Maturation Cell Morphogenesis Involved In Differentiation Substrate-dependent Cell Migration Pyrimidine Nucleobase Metabolic Process Regulation Of Cell Adhesion Mediated By Integrin Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Phosphatidylinositol 3-kinase Activity Neuron Development Lung Epithelial Cell Differentiation Regulation Of Lipid Kinase Activity Carboxylic Acid Metabolic Process Lung Cell Differentiation Cell Differentiation Cell Morphogenesis Lung Epithelium Development Neuron Differentiation Organic Acid Metabolic Process Cell Projection Organization Locomotion Ephrin Receptor Signaling Pathway	Pyrimidine Nucleobase Catabolic Process Pyrimidine Nucleobase Metabolic Process Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Catabolic Process Response To External Stimulus Neuron Development Regulation Of Neuron Projection Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Mitochondrial Asparaginyl-tRNA Aminoacylation Regulation Of Protein Folding In Endoplasmic Reticulum Nervous System Development Small Molecule Metabolic Process Regulation Of Cell Projection Organization Locomotion Anatomical Structure Morphogenesis Regulation Of Neuron Differentiation Cerebellum Structural Organization Uracil Catabolic Process Movement Of Cell Or Subcellular Component Regulation Of Cell Motility Beta-alanine Metabolic Process Uracil Metabolic Process Thymine Metabolic Process Thymine Catabolic Process Generation Of Neurons Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Neurogenesis Neurogenesis Positive Regulation Of Glutamate Secretion TRNA Aminoacylation For Mitochondrial Protein Translation Cell Development Regulation Of Cell Development Regulation Of Cellular Component Organization Positive Regulation Of Neuron Projection Development Asparaginyl-tRNA Aminoacylation Protein Homooligomerization ER Overload Response
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