DARS2 and AOC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DARS2	AOC3
Description		aspartyl-tRNA synthetase 2, mitochondrial	amine oxidase copper containing 3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Mitochondrial Membrane	Cytoplasm Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus Cell Surface Membrane
	Molecular Function	TRNA Binding Nucleotide Binding Nucleic Acid Binding Aminoacyl-tRNA Ligase Activity Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity	Copper Ion Binding Calcium Ion Binding Protein Binding Primary Methylamine Oxidase Activity Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity Quinone Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Aspartyl-tRNA Aminoacylation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation	Inflammatory Response Cell Adhesion Amine Metabolic Process
Pathways		Mitochondrial tRNA aminoacylation	Phase I - Functionalization of compounds
Drugs		Aspartic acid	Phenelzine Hydralazine 6-hydroxydopa quinone
Diseases		Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		16 interacting genes: AIMP2 ALDH18A1 AOC3 CDIPT CFTR COL8A2 CYB561 DPYSL5 EPHA8 FETUB KARS1 PLP2 THSD7B TMEM239 TSPAN33 UNC50	13 interacting genes: ARL13B CLDN9 CPLX4 CREB3L1 DARS2 FNDC9 HSD17B13 LMNA MYBPC2 PRRG4 SGTA STX1A VAV1
Entrez ID		55157	8639
HPRD ID		07677	04770
Ensembl ID		ENSG00000117593	ENSG00000131471
Uniprot IDs		A0A3B3IT01 A0A3B3ITS3 Q6PI48 Q9H9J7	Q16853 Q9UEU7
PDB IDs		4AH6	1PU4 1US1 2C10 2C11 2Y73 2Y74 3ALA 4BTW 4BTX 4BTY 8S1Z
Enriched GO Terms of Interacting Partners?		Aminoacyl-tRNA Synthetase Multienzyme Complex
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