BMX and PTPN21

Number of citations of the paper that reports this interaction (PubMedID 11013262)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		BMX	PTPN21
Description		BMX non-receptor tyrosine kinase	protein tyrosine phosphatase non-receptor type 21
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Ruffle Membrane	Cytoplasm Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Adaptive Immune Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Cell Adhesion Signal Transduction Mesoderm Development Intracellular Signal Transduction Protein Autophosphorylation B Cell Receptor Signaling Pathway	Protein Dephosphorylation
Pathways		Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS			Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		26 interacting genes: APP BCAR1 BIRC2 BTK CASP3 CAV1 CLNK EGFR ERBB2 FBXO25 ITK KDR NOPCHAP1 PAK1 PTK2 PTPN21 PTPRD RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B	27 interacting genes: AKAP1 ATOSB BAG3 BMX CATSPER1 CWC22 ERBB4 FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 UBASH3B VPS26C YAP1 ZNF497
Entrez ID		660	11099
HPRD ID		02111	04468
Ensembl ID		ENSG00000102010	ENSG00000070778
Uniprot IDs		P51813	Q16825
PDB IDs		2EKX 2YS2 3SXR 3SXS 6I99 8X2A	8GVL 8GVV 8GWH 8GXE 8Y8Y
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Defense Response Positive Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Positive Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Positive Regulation Of Defense Response Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Regulation Of Cell Activation Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Differentiation Membrane Raft Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Regulation Of Developmental Process Immune Response-activating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Modification Process Regulation Of Epithelial Cell Proliferation Regulation Of Vesicle-mediated Transport Immune System Process Regulation Of Cell Junction Assembly ERBB Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Signal Transduction	Protein Phosphorylation Cardiac Muscle Tissue Regeneration Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Phosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Centriolar Satellite Tissue Regeneration Intestinal Epithelial Cell Development Protein Kinase Activity U2-type Catalytic Step 1 Spliceosome Microtubule-based Process Columnar/cuboidal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Cytoskeleton Kinase Activity Establishment Of Planar Polarity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein ERBB2 Signaling Pathway Mitotic Spindle Organization Spindle Assembly Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Polarized Epithelial Cell Differentiation Positive Regulation Of Protein Localization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cardiac Muscle Cell Proliferation
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