BMX and RUFY2

Number of citations of the paper that reports this interaction (PubMedID 11877430)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		BMX	RUFY2
Description		BMX non-receptor tyrosine kinase	RUN and FYVE domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Ruffle Membrane	Nucleus Cytoplasm Endosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding	Protein Binding Zinc Ion Binding SH3 Domain Binding Metal Ion Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Cell Adhesion Signal Transduction Mesoderm Development Intracellular Signal Transduction Protein Autophosphorylation B Cell Receptor Signaling Pathway	Regulation Of Endocytosis
Pathways		Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS			Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: APP BCAR1 BIRC2 BTK CASP3 CAV1 CLNK EGFR ERBB2 FBXO25 ITK KDR NOPCHAP1 PAK1 PTK2 PTPN21 PTPRD RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B	7 interacting genes: BMX DSCAM DUSP23 EPHA3 RAB33A RAB33B SF3B3
Entrez ID		660	55680
HPRD ID		02111	11526
Ensembl ID		ENSG00000102010	ENSG00000204130
Uniprot IDs		P51813	Q5GIA6 Q8WXA3
PDB IDs		2EKX 2YS2 3SXR 3SXS 6I99 8X2A
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Defense Response Positive Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Positive Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Positive Regulation Of Defense Response Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Regulation Of Cell Activation Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Differentiation Membrane Raft Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Regulation Of Developmental Process Immune Response-activating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Modification Process Regulation Of Epithelial Cell Proliferation Regulation Of Vesicle-mediated Transport Immune System Process Regulation Of Cell Junction Assembly ERBB Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Signal Transduction	Rab Protein Signal Transduction Neuron Recognition Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Fasciculation Of Motor Neuron Axon Autophagosome Organization Autophagosome Assembly Negative Regulation Of Constitutive Secretory Pathway Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER Protein Tyrosine Kinase Activity Cell Recognition Fasciculation Of Sensory Neuron Axon
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