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PIK3CA and RASGRP3
Number of citations of the paper that reports this interaction (PubMedID
15213298
)
0
Data Source:
BioGRID
(enzymatic study)
PIK3CA
RASGRP3
Description
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
RAS guanyl releasing protein 3
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Phosphatidylinositol 3-kinase Complex, Class IB
Intercalated Disc
Lamellipodium
Perinuclear Region Of Cytoplasm
Cytoplasm
Plasma Membrane
Guanyl-nucleotide Exchange Factor Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Nucleotide Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Transferase Activity
Protein Kinase Activator Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
Insulin Receptor Substrate Binding
1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Protein Serine Kinase Activity
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Kinase Binding
Diacylglycerol Binding
GTPase Regulator Activity
Small GTPase Binding
Metal Ion Binding
Biological Process
Angiogenesis
Liver Development
Vasculature Development
Glucose Metabolic Process
Lipid Metabolic Process
Phagocytosis
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Regulation Of Gene Expression
Positive Regulation Of Lamellipodium Assembly
Negative Regulation Of Gene Expression
Response To Activity
Response To Muscle Inactivity
Negative Regulation Of Macroautophagy
Cell Migration
Actin Cytoskeleton Organization
Platelet Activation
Negative Regulation Of Actin Filament Depolymerization
Positive Regulation Of TOR Signaling
Cellular Response To Insulin Stimulus
Response To Muscle Stretch
Phosphatidylinositol-3-phosphate Biosynthetic Process
Vascular Endothelial Growth Factor Signaling Pathway
Regulation Of Multicellular Organism Growth
Response To L-leucine
Anoikis
Regulation Of Cellular Respiration
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Neuron Apoptotic Process
Endothelial Cell Migration
Phosphatidylinositol Phosphate Biosynthetic Process
Insulin-like Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Smooth Muscle Cell Proliferation
T Cell Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Relaxation Of Cardiac Muscle
Cardiac Muscle Contraction
Adipose Tissue Development
Cellular Response To Glucose Stimulus
Cellular Response To Hydrostatic Pressure
Response To Dexamethasone
Cardiac Muscle Cell Contraction
Energy Homeostasis
Regulation Of Actin Filament Organization
Autosome Genomic Imprinting
Response To Butyrate
Positive Regulation Of Protein Localization To Membrane
Negative Regulation Of Fibroblast Apoptotic Process
Negative Regulation Of Anoikis
MAPK Cascade
Small GTPase-mediated Signal Transduction
Ras Protein Signal Transduction
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
Extra-nuclear estrogen signaling
RAC1 GTPase cycle
RAC2 GTPase cycle
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Activated NTRK3 signals through PI3K
FLT3 Signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF1 (M-CSF) in myeloid cells
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by ALK fusions and activated point mutants
Signaling by LTK in cancer
Signaling by LTK
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Co-stimulation by ICOS
Activation of RAS in B cells
Activation of RAS in B cells
RAF/MAP kinase cascade
Drugs
ATP
Caffeine
XL765
Wortmannin
Pilaralisib
Alpelisib
Copanlisib
Diseases
Ovarian cancer
GWAS
Mean corpuscular hemoglobin (
29403010
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Albumin-globulin ratio (
29403010
)
Bronchopulmonary dysplasia in preterm infants (
30113228
)
Hypertension (young onset) (
19421330
)
IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) (
26741287
)
Metabolite levels (
23823483
)
Multiple system atrophy (pathologically confirmed) (
27629089
)
Non-albumin protein levels (
29403010
)
Non-response to antidepressants and depression (
27622933
)
Sjögren's syndrome (
24097067
)
Systemic lupus erythematosus (
19838193
23273568
26663301
27399966
28714469
33272962
)
Interacting Genes
69 interacting genes:
ADAP1
AKT1
AMBP
APLP2
APPL1
ARAF
ATP5IF1
ATR
BEX1
BEX2
CCND2
CSF1R
CYTH2
CYTH3
DDX5
DNAJB6
EGFR
FANCC
FASLG
FBP2
FTL
GABRB1
GALNT12
GLIS2
GNAQ
GRIN2B
HRAS
IL13RA2
IL24
IL3
IRS2
IRS4
ITIH1
KRAS
LCK
MAP2K1
MRAS
MYC
NEDD9
NRAS
PDGFRA
PDGFRB
PDK1
PIK3R1
PIK3R3
PRKCD
PSMC3IP
PTPN11
RASD2
RASGRP3
RELA
RPS20
RPS6KB1
SFRP4
SGK1
SH3KBP1
SMAD2
SMAD3
SNX9
SQSTM1
STAT1
STK11
THRSP
TICAM1
TMOD1
TNFSF13
UFD1
UMPS
VARS2
11 interacting genes:
APP
DYNLL2
GET1
HSD17B11
PIK3CA
PRKACA
PRKCB
PRKCD
PRKCE
PRKCQ
SULT1C2
Entrez ID
5290
25780
HPRD ID
01382
15213
Ensembl ID
ENSG00000121879
ENSG00000152689
Uniprot IDs
P42336
Q8IV61
PDB IDs
2ENQ
2RD0
3HHM
3HIZ
3ZIM
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4TUU
4TV3
4WAF
4YKN
4ZOP
5DXH
5DXT
5FI4
5ITD
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBR
5UK8
5UKJ
5UL1
5XGH
5XGI
5XGJ
6GVF
6GVG
6GVH
6GVI
6NCT
6OAC
6PYS
6VO7
7JIU
7K6M
7K6N
7K6O
7K71
7L1B
7L1C
7L1D
7MLK
7MYN
7MYO
7PG5
7PG6
7R9V
7R9Y
7RRG
7TZ7
8AM0
8BFU
8DCP
8DCX
8DD4
8DD8
8EXL
8EXO
8EXU
8EXV
8GUA
8GUB
8GUD
8ILR
8ILS
8ILV
8OW2
8SBC
8SBJ
8TDU
8TGD
8TS7
8TS8
8TS9
8TSA
8TSB
8TSC
8TSD
8TU6
8TWY
8V8H
8V8I
8V8J
8V8U
8V8V
8VCL
8W9A
8W9B
9ASF
9ASG
9B4S
9B4T
9C15
9E8M
Enriched GO Terms of Interacting Partners
?
Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Regulation Of Signal Transduction
Positive Regulation Of Signaling
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Protein Kinase Activity
Intracellular Signaling Cassette
Regulation Of Apoptotic Process
Insulin Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Cytosol
Kinase Activity
Positive Regulation Of D-glucose Import
Cytoplasm
Cell Population Proliferation
Regulation Of Protein Localization To Cell Periphery
Response To UV
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of D-glucose Transmembrane Transport
Cell Migration
Nucleotide Binding
Negative Regulation Of Programmed Cell Death
Response To Radiation
Regulation Of Protein Localization
Regulation Of Protein Localization To Membrane
Phospholipase C Activator Activity
MAPK Cascade
Response To Hormone
Protein Kinase Binding
Regulation Of Protein Modification Process
Cell Motility
Response To Growth Factor
Response To Light Stimulus
Negative Regulation Of Apoptotic Process
Apoptotic Signaling Pathway
Regulation Of D-glucose Import
Positive Regulation Of Gene Expression
Regulation Of Actin Cytoskeleton Organization
Protein Phosphorylation
Positive Regulation Of Metabolic Process
Diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Localization
Regulation Of Superoxide Anion Generation
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Protein Transport
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Superoxide Metabolic Process
Positive Regulation Of Establishment Of Protein Localization
Kinase Activity
Cell Activation
Protein Kinase C Signaling
Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity
Peptidyl-serine Phosphorylation
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Cellular Response To Insulin Stimulus
Immune Response-regulating Signaling Pathway
Regulation Of Protein Transport
Fc Receptor Signaling Pathway
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Signaling Receptor Activator Activity
Protein Kinase Activity
Regulation Of Protein Localization
Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Establishment Of Protein Localization
Cellular Response To Carbohydrate Stimulus
Regulation Of Cellular Response To Insulin Stimulus
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Cytosol
Leukocyte Activation
Positive Regulation Of Insulin Secretion
Positive Regulation Of Immune System Process
Insulin Receptor Substrate Binding
Transferase Activity
Positive Regulation Of Immune Response
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of Peptide Secretion
Intracellular Signal Transduction
Cellular Response To Hormone Stimulus
Perinuclear Region Of Cytoplasm
Protein Phosphorylation
Regulation Of Biological Quality
Immune Response-activating Signaling Pathway
Myeloid Leukocyte Activation
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Supramolecular Fiber Organization
Regulation Of Reactive Oxygen Species Metabolic Process
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