INPP5A and PLEK

Number of citations of the paper that reports this interaction (PMID 8999861)
10

Data Source:
HPRD (in vitro)

		INPP5A	PLEK
Gene Name		inositol polyphosphate-5-phosphatase, 40kDa	pleckstrin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Vesicular Exosome	Extracellular Region Cytoplasm Cytosol Membrane Ruffle Membrane
	Molecular Function	Inositol-polyphosphate 5-phosphatase Activity Protein Binding PH Domain Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity	Protein Kinase C Binding Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation	Hematopoietic Progenitor Cell Differentiation Platelet Degranulation Vesicle Docking Involved In Exocytosis Integrin-mediated Signaling Pathway Blood Coagulation Positive Regulation Of Platelet Activation Negative Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Inositol-polyphosphate 5-phosphatase Activity Cell Projection Organization Platelet Activation Positive Regulation Of Actin Filament Depolymerization Phospholipase C-inhibiting G-protein Coupled Receptor Signaling Pathway Cortical Actin Cytoskeleton Organization Ruffle Organization Actin Cytoskeleton Reorganization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Integrin Activation Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Phosphatidylinositol Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Diameter Thrombin Receptor Signaling Pathway Platelet Aggregation Protein Kinase C Signaling Protein Secretion By Platelet
Pathways		Synthesis of IP2, IP, and Ins in the cytosol Inositol phosphate metabolism	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Metabolite levels ( 19043545) Multiple sclerosis ( 22190364 21833088)
Protein-Protein Interactions		2 interactors: PLEK YWHAZ	3 interactors: ACVR1 INPP5A TGFBR1
Entrez ID		3632	5341
HPRD ID		02521	15935
Ensembl ID		ENSG00000068383	ENSG00000115956
Uniprot IDs		Q14642 Q8N6C1	P08567
PDB IDs			1PLS 1W4M 1X05 1XX0 1ZM0 2CSO 2I5C 2I5F
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Inositol-polyphosphate 5-phosphatase Activity Negative Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Cell Diameter Phospholipase C-inhibiting G-protein Coupled Receptor Signaling Pathway Exocytosis Protein Secretion By Platelet Positive Regulation Of Organelle Organization Golgi Reassembly Blood Coagulation Hemostasis Positive Regulation Of Integrin Activation Histamine Secretion By Mast Cell Secretion By Cell Establishment Of Golgi Localization Golgi Inheritance Positive Regulation Of Platelet Activation Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Calcium-mediated Signaling Secretion Histamine Secretion Cell Activation Regulation Of Integrin Activation Response To Wounding Thrombin Receptor Signaling Pathway Histamine Transport Positive Regulation Of Actin Filament Depolymerization Golgi Localization Regulation Of Organelle Organization Positive Regulation Of Protein Depolymerization Mast Cell Degranulation Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Mast Cell Mediated Immunity Cortical Actin Cytoskeleton Organization Lysosome Localization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mast Cell Activation Protein Kinase C Signaling Positive Regulation Of Protein Complex Disassembly Cortical Cytoskeleton Organization Regulation Of Platelet Activation Positive Regulation Of Phosphatase Activity Positive Regulation Of Blood Coagulation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Leukocyte Degranulation Ruffle Organization Platelet Aggregation Positive Regulation Of Coagulation	Pathway-restricted SMAD Protein Phosphorylation Pharyngeal System Development Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchymal Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Endocardial Cushion Cell Fate Commitment Ameboidal-type Cell Migration Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchyme Development Heart Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Stem Cell Development Negative Regulation Of Apoptotic Signaling Pathway Signal Transduction By Phosphorylation Cell Fate Commitment Stem Cell Differentiation Embryonic Organ Morphogenesis Angiogenesis Mitral Valve Morphogenesis Cardiac Muscle Cell Fate Commitment Urogenital System Development Mitral Valve Development Blood Vessel Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Parathyroid Gland Development Negative Regulation Of Activin Receptor Signaling Pathway Pattern Specification Process Atrial Septum Primum Morphogenesis Endocardial Cell Differentiation Embryonic Organ Development Septum Primum Development In Utero Embryonic Development Blood Vessel Development Heart Development Endothelial Cell Activation Vasculature Development Cellular Response To Growth Factor Stimulus Positive Regulation Of SMAD Protein Import Into Nucleus Phosphate-containing Compound Metabolic Process Response To Growth Factor Regulation Of SMAD Protein Import Into Nucleus Embryonic Morphogenesis
Tagcloud ?		accumulate alterations anaplastic astrocytoma consequence correlations cps1 genomic glial glioblastoma glioma gp2 htr4 implies instability itgb1 kcng2 kir3dl3 lhfpl3 p16 passenger pathogenesis pde4d predominantly pros1 pten seem sgcg subtypes	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin ncf1 nucleic onto pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine
Tagcloud (Difference) ?		accumulate alterations anaplastic astrocytoma consequence correlations cps1 genomic glial glioblastoma glioma gp2 htr4 implies instability itgb1 kcng2 kir3dl3 lhfpl3 p16 passenger pathogenesis pde4d predominantly pros1 pten seem sgcg subtypes	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin ncf1 nucleic onto pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine
Tagcloud (Intersection) ?