INPP5A

Description		inositol polyphosphate-5-phosphatase A
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Cell Projection
	Molecular Function	Inositol-polyphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity PH Domain Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Phosphate-containing Compound Metabolic Process Organophosphate Metabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Dephosphorylation Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Synthesis of IP2, IP, and Ins in the cytosol
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Gait speed in old age ( 28077804) Heel bone mineral density ( 28869591 30598549) Migraine ( 27182965) Primary sclerosing cholangitis ( 27992413) Pulse pressure ( 30578418) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 30275531)
Novel Interacting Genes		1 novel interacting genes: TUBGCP2
Interacting Genes		3 interacting genes: PLEK TEAD2 YWHAZ
Entrez ID		3632
HPRD ID		02521
Ensembl ID		ENSG00000068383
Uniprot IDs		Q14642
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Diameter Protein Secretion By Platelet Negative Regulation Of Inositol Phosphate Biosynthetic Process Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Synaptic Target Recognition Tube Formation Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Platelet Degranulation Golgi Reassembly TEAD-YAP Complex Lateral Mesoderm Development Phosphatase Activator Activity Phosphoserine Residue Binding Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Integrin Activation Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Platelet Activation Regulation Of Lysosome Organization Golgi Localization Establishment Of Golgi Localization Animal Organ Development Notochord Development Paraxial Mesoderm Development Microtubule Minus-end Binding Gamma-tubulin Complex Organelle Localization Positive Regulation Of Protein Depolymerization Intracellular Signal Transduction Regulation Of Integrin Activation Antibacterial Innate Immune Response
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