INPP5A and TEAD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		INPP5A	TEAD2
Description		inositol polyphosphate-5-phosphatase A	TEA domain transcription factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Cell Projection	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol TEAD-YAP Complex
	Molecular Function	Inositol-polyphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity PH Domain Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Disordered Domain Specific Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Phosphate-containing Compound Metabolic Process Organophosphate Metabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Dephosphorylation Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway	Vasculogenesis Neural Tube Closure Embryonic Heart Tube Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Notochord Development Hippo Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Embryonic Organ Development Mesenchyme Development Protein-containing Complex Assembly Cellular Response To Retinoic Acid Regulation Of Stem Cell Differentiation
Pathways		Synthesis of IP2, IP, and Ins in the cytosol	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Formation of axial mesoderm Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Gait speed in old age ( 28077804) Heel bone mineral density ( 28869591 30598549) Migraine ( 27182965) Primary sclerosing cholangitis ( 27992413) Pulse pressure ( 30578418) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 30275531)
Interacting Genes		3 interacting genes: PLEK TEAD2 YWHAZ	45 interacting genes: AKT1 ARNT AURKA BCL2L15 BECN1 C14orf39 CCND2 CDK4 CDK6 CDKN2A CDKN2B DACH1 EPHA2 FGFR4 FZR1 GLIS1 GLIS2 GNG13 HGF HIF1A INPP5A LATS2 MAP2K3 MAP2K5 MAP3K5 MYC NCOA1 NEDD4 NFIC NSD3 RAF1 RASSF1 RUNX1 SAA2 SOX3 STK11 TERT TP53 TRIM3 USF2 VGLL1 VGLL3 VGLL4 WWTR1 YAP1
Entrez ID		3632	8463
HPRD ID		02521	03432
Ensembl ID		ENSG00000068383	ENSG00000074219
Uniprot IDs		Q14642	Q15562
PDB IDs			3L15 5DQ8 5DQE 5EMV 5HGU 6CDY 6E5G 6S60 6S64 6S66 6S69 6S6J 6UYB 6UYC 6VAH 7OYJ 7T2J 7T2K 7T2L 7T2M 7TYP 7TYQ 7TYU 8CUH 8E1O 8P29 8POJ 8POM 8PON 8PUX 8PUY 8RXL 8RXP 8RXQ 8RXV 8RYC 8YGQ
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Diameter Protein Secretion By Platelet Negative Regulation Of Inositol Phosphate Biosynthetic Process Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Synaptic Target Recognition Tube Formation Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Platelet Degranulation Golgi Reassembly TEAD-YAP Complex Lateral Mesoderm Development Phosphatase Activator Activity Phosphoserine Residue Binding Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Integrin Activation Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Platelet Activation Regulation Of Lysosome Organization Golgi Localization Establishment Of Golgi Localization Animal Organ Development Notochord Development Paraxial Mesoderm Development Microtubule Minus-end Binding Gamma-tubulin Complex Organelle Localization Positive Regulation Of Protein Depolymerization Intracellular Signal Transduction Regulation Of Integrin Activation Antibacterial Innate Immune Response	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Process Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Cycle Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Epithelial Cell Proliferation Protein Serine Kinase Activity Regulation Of Cell Differentiation Cell Population Proliferation Regulation Of Developmental Process Cellular Response To Stress Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Cell Population Proliferation Regulation Of Apoptotic Signaling Pathway Developmental Process Negative Regulation Of Metabolic Process
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