CXCL10 and CXCR3

Number of citations of the paper that reports this interaction (PMID 12782716)
91

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		CXCL10	CXCR3
Gene Name		chemokine (C-X-C motif) ligand 10	chemokine (C-X-C motif) receptor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Receptor Binding Protein Binding Chemokine Activity Heparin Binding CAMP-dependent Protein Kinase Regulator Activity CXCR3 Chemokine Receptor Binding	Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-X-C Chemokine Binding
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Muscle Organ Development Blood Circulation Positive Regulation Of Cell Proliferation Protein Secretion Response To Cold Response To Gamma Radiation T Cell Chemotaxis Response To Auditory Stimulus Negative Regulation Of Angiogenesis Positive Regulation Of CAMP Metabolic Process Response To Vitamin D Cellular Response To Heat Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Myoblast Differentiation Regulation Of Protein Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Myoblast Fusion Positive Regulation Of T Cell Migration	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Leukocyte Migration Apoptotic Process Movement Of Cell Or Subcellular Component Chemotaxis Inflammatory Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation T Cell Chemotaxis Negative Regulation Of Angiogenesis Calcium-mediated Signaling Positive Regulation Of CAMP Metabolic Process Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 11 Production Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		N-Methylleucine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CCR3 CXCR3 DPP4 IGFBP7 VCAN	6 interactors: CXCL10 CXCL11 CXCL13 CXCL9 PF4 VCAN
Entrez ID		3627	2833
HPRD ID		00930	02936
Ensembl ID		ENSG00000169245	ENSG00000186810
Uniprot IDs		P02778	P49682
PDB IDs		1LV9 1O7Y 1O7Z 1O80
Enriched GO Terms of Interacting Partners?		Cell Adhesion Locomotion Chemokine-mediated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Endothelial Cell Proliferation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Proliferation Chemokine (C-C Motif) Ligand 11 Production Cell Migration Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Motility Cytosolic Calcium Ion Homeostasis Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Regulation Of Angiogenesis Response To Cortisol Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Chemotaxis Response To Stress Chemokine Production Dermatan Sulfate Biosynthetic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Execution Phase Of Apoptosis Dermatan Sulfate Proteoglycan Biosynthetic Process Cellular Metal Ion Homeostasis Dermatan Sulfate Proteoglycan Metabolic Process Positive Regulation Of CAMP-mediated Signaling Chondroitin Sulfate Catabolic Process Inflammatory Response Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Lymphocyte Chemotaxis Metal Ion Homeostasis T Cell Migration Cellular Response To Organic Substance Regulation Of CAMP-mediated Signaling Chondroitin Sulfate Biosynthetic Process Cellular Chemical Homeostasis Regulation Of Execution Phase Of Apoptosis Ion Homeostasis Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Cytokine Stimulus Chemotaxis Lymphocyte Migration	Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of CAMP-mediated Signaling Lymphocyte Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of CAMP-mediated Signaling Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Lymphocyte Migration Regulation Of Chemotaxis Cell Chemotaxis Regulation Of Behavior Leukocyte Migration T Cell Chemotaxis Positive Regulation Of CAMP Metabolic Process Cell Migration Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Lipopolysaccharide Positive Regulation Of Cell Migration Response To Molecule Of Bacterial Origin Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of CAMP Metabolic Process T Cell Migration Inflammatory Response Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Locomotion Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Lipid Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Immune System Process Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Calcium Ion Transport G-protein Coupled Receptor Signaling Pathway
Tagcloud ?		a1 adds allocation apolipoprotein beyond biomarkers composite counting deviation ever fourth immunoassay incident individually kallikrein longitudinal metalloproteinase mi multivariable net norway platform reclassification roc stepwise thrombospondin traditional tromso utilizes	allergic cc ccr1 ccr3 ccr4 ccr5 chemokine chemokines coreceptors cxcr1 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate
Tagcloud (Difference) ?		a1 adds allocation apolipoprotein beyond biomarkers composite counting deviation ever fourth immunoassay incident individually kallikrein longitudinal metalloproteinase mi multivariable net norway platform reclassification roc stepwise thrombospondin traditional tromso utilizes	allergic cc ccr1 ccr3 ccr4 ccr5 chemokine chemokines coreceptors cxcr1 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate
Tagcloud (Intersection) ?