CXCL10 and CXCL17

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CXCL10	CXCL17
Description		C-X-C motif chemokine ligand 10	C-X-C motif chemokine ligand 17
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CAMP-dependent Protein Kinase Regulator Activity Chemoattractant Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding	Protein Binding
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Muscle Organ Development Blood Circulation Positive Regulation Of Cell Population Proliferation Response To Bacterium Response To Gamma Radiation T Cell Chemotaxis Regulation Of T Cell Chemotaxis Response To Auditory Stimulus Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Neutrophil Chemotaxis Killing Of Cells Of Another Organism Response To Lipopolysaccharide Response To Vitamin D Cellular Response To Heat Endothelial Cell Activation Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Cellular Response To Interleukin-17 Cellular Response To Virus Antiviral Innate Immune Response Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Myoblast Fusion Positive Regulation Of T Cell Migration	Angiogenesis Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Cell Differentiation Macrophage Chemotaxis Negative Regulation Of Inflammatory Response Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		N-Methylleucine Eldelumab Clove oil
Diseases
GWAS		Blood protein levels ( 30072576) C-X-C motif chemokine 10 levels ( 25147954) Hippocampal volume ( 29274321) Interferon gamma-induced protein 10 levels ( 27989323 31217265) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		22 interacting genes: CCL11 CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CCR3 CXCL11 CXCL12 CXCL14 CXCL17 CXCL6 CXCL9 CXCR3 DPP4 IGFBP7 PF4 PF4V1 PPBP VCAN XCL1	16 interacting genes: CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CCL8 CXCL10 CXCL12 CXCL14 CXCL9 PF4 XCL1 XCL2
Entrez ID		3627	284340
HPRD ID		00930	18264
Ensembl ID		ENSG00000169245	ENSG00000189377
Uniprot IDs		P02778	Q6UXB2
PDB IDs		1LV9 1O7Y 1O7Z 1O80 8K2X
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Leukocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Leukocyte Migration Cytokine Activity Cell Migration Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Humoral Immune Response Granulocyte Migration Cell Motility Killing Of Cells Of Another Organism Inflammatory Response Defense Response Cell Killing CXCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Extracellular Space Immune Response Defense Response To Symbiont Immune System Process Defense Response To Other Organism Extracellular Region CCR Chemokine Receptor Binding Response To Other Organism Mononuclear Cell Migration G Protein-coupled Receptor Signaling Pathway Response To External Biotic Stimulus Eosinophil Chemotaxis Eosinophil Migration Neutrophil Chemotaxis Chemokine Receptor Binding Neutrophil Migration Regulation Of Leukocyte Migration Response To Stress Lymphocyte Chemotaxis Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion Cell-cell Signaling Signaling Signal Transduction	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Humoral Immune Response Chemotaxis Locomotion Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Leukocyte Chemotaxis Granulocyte Migration Leukocyte Migration Killing Of Cells Of Another Organism Myeloid Leukocyte Migration Defense Response To Symbiont CCR Chemokine Receptor Binding Defense Response To Other Organism Cell Migration Cell Killing Cell Motility Response To Other Organism Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Response To External Biotic Stimulus Defense Response Extracellular Space Eosinophil Chemotaxis Eosinophil Migration Chemokine Receptor Binding Mononuclear Cell Migration Immune System Process Regulation Of Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Extracellular Region Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Lymphocyte Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of T Cell Migration CXCR Chemokine Receptor Binding Negative Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Lymphocyte Migration Response To Stress Positive Regulation Of Mononuclear Cell Migration
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