CXCL10 and CCR3

Number of citations of the paper that reports this interaction (PMID 11110785)
48

Data Source:
HPRD (in vitro)

		CXCL10	CCR3
Gene Name		chemokine (C-X-C motif) ligand 10	chemokine (C-C motif) receptor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Binding Protein Binding Chemokine Activity Heparin Binding CAMP-dependent Protein Kinase Regulator Activity CXCR3 Chemokine Receptor Binding	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Muscle Organ Development Blood Circulation Positive Regulation Of Cell Proliferation Protein Secretion Response To Cold Response To Gamma Radiation T Cell Chemotaxis Response To Auditory Stimulus Negative Regulation Of Angiogenesis Positive Regulation Of CAMP Metabolic Process Response To Vitamin D Cellular Response To Heat Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Myoblast Differentiation Regulation Of Protein Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Myoblast Fusion Positive Regulation Of T Cell Migration	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Cellular Defense Response Cell Adhesion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		N-Methylleucine
Diseases
GWAS			Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140) Monocyte chemoattractant protein-1 ( 23017229) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: CCR3 CXCR3 DPP4 IGFBP7 VCAN	19 interactors: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		3627	1232
HPRD ID		00930	03167
Ensembl ID		ENSG00000169245	ENSG00000183625
Uniprot IDs		P02778	P51677 Q8TDP4 Q8TDP5
PDB IDs		1LV9 1O7Y 1O7Z 1O80
Enriched GO Terms of Interacting Partners?		Cell Adhesion Locomotion Chemokine-mediated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Endothelial Cell Proliferation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Proliferation Chemokine (C-C Motif) Ligand 11 Production Cell Migration Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Motility Cytosolic Calcium Ion Homeostasis Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Regulation Of Angiogenesis Response To Cortisol Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Chemotaxis Response To Stress Chemokine Production Dermatan Sulfate Biosynthetic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Execution Phase Of Apoptosis Dermatan Sulfate Proteoglycan Biosynthetic Process Cellular Metal Ion Homeostasis Dermatan Sulfate Proteoglycan Metabolic Process Positive Regulation Of CAMP-mediated Signaling Chondroitin Sulfate Catabolic Process Inflammatory Response Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Lymphocyte Chemotaxis Metal Ion Homeostasis T Cell Migration Cellular Response To Organic Substance Regulation Of CAMP-mediated Signaling Chondroitin Sulfate Biosynthetic Process Cellular Chemical Homeostasis Regulation Of Execution Phase Of Apoptosis Ion Homeostasis Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Cytokine Stimulus Chemotaxis Lymphocyte Migration	Cell Chemotaxis Cell Migration Cell Motility Chemotaxis Locomotion Immune Response Movement Of Cell Or Subcellular Component Inflammatory Response Response To External Stimulus Immune System Process Leukocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Leukocyte Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Eosinophil Chemotaxis Positive Regulation Of Leukocyte Migration Defense Response Eosinophil Migration Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cellular Component Movement Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Granulocyte Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Regulation Of Lymphocyte Migration Cellular Metal Ion Homeostasis Regulation Of Cell Shape Cellular Cation Homeostasis Cell-cell Signaling Cellular Ion Homeostasis Positive Regulation Of Calcium Ion Transport Metal Ion Homeostasis Regulation Of Behavior Response To Other Organism Lymphocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Response To Biotic Stimulus T Cell Migration Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Immune System Process Regulation Of Immune System Process
Tagcloud ?		a1 adds allocation apolipoprotein beyond biomarkers composite counting deviation ever fourth immunoassay incident individually kallikrein longitudinal metalloproteinase mi multivariable net norway platform reclassification roc stepwise thrombospondin traditional tromso utilizes	basophil basophils c5a ccr2 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Difference) ?		a1 adds allocation apolipoprotein beyond biomarkers composite counting deviation ever fourth immunoassay incident individually kallikrein longitudinal metalloproteinase mi multivariable net norway platform reclassification roc stepwise thrombospondin traditional tromso utilizes	basophil basophils c5a ccr2 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Intersection) ?