CXCL10

Gene Name		chemokine (C-X-C motif) ligand 10
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane
	Molecular Function	Receptor Binding Protein Binding Chemokine Activity Heparin Binding CAMP-dependent Protein Kinase Regulator Activity CXCR3 Chemokine Receptor Binding
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Muscle Organ Development Blood Circulation Positive Regulation Of Cell Proliferation Protein Secretion Response To Cold Response To Gamma Radiation T Cell Chemotaxis Response To Auditory Stimulus Negative Regulation Of Angiogenesis Positive Regulation Of CAMP Metabolic Process Response To Vitamin D Cellular Response To Heat Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Myoblast Differentiation Regulation Of Protein Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Myoblast Fusion Positive Regulation Of T Cell Migration
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		N-Methylleucine
Diseases
GWAS
Protein-protein Interactions		5 interactors: CCR3 CXCR3 DPP4 IGFBP7 VCAN
Entrez ID		3627
HPRD ID		00930
Ensembl ID		ENSG00000169245
Uniprot IDs		P02778
PDB IDs		1LV9 1O7Y 1O7Z 1O80
Enriched GO Terms of Interacting Partners?		Cell Adhesion Locomotion Chemokine-mediated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Endothelial Cell Proliferation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Proliferation Chemokine (C-C Motif) Ligand 11 Production Cell Migration Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Motility Cytosolic Calcium Ion Homeostasis Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Regulation Of Angiogenesis Response To Cortisol Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Chemotaxis Response To Stress Chemokine Production Dermatan Sulfate Biosynthetic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Execution Phase Of Apoptosis Dermatan Sulfate Proteoglycan Biosynthetic Process Cellular Metal Ion Homeostasis Dermatan Sulfate Proteoglycan Metabolic Process Positive Regulation Of CAMP-mediated Signaling Chondroitin Sulfate Catabolic Process Inflammatory Response Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Lymphocyte Chemotaxis Metal Ion Homeostasis T Cell Migration Cellular Response To Organic Substance Regulation Of CAMP-mediated Signaling Chondroitin Sulfate Biosynthetic Process Cellular Chemical Homeostasis Regulation Of Execution Phase Of Apoptosis Ion Homeostasis Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Cytokine Stimulus Chemotaxis Lymphocyte Migration
Tagcloud ?		a1 adds allocation apolipoprotein beyond biomarkers composite counting deviation ever fourth immunoassay incident individually kallikrein longitudinal metalloproteinase mi multivariable net norway platform reclassification roc stepwise thrombospondin traditional tromso utilizes